Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Abstract: Systems and methods for providing an interactive media guidance application for merging recorded video segments that are from the same program are provided. In response to a recording interruption, the interactive media guidance application may record multiple video segments. After recording the segments, the interactive media guidance application may search for and merge these segments to form a single recording. In some embodiments, the interactive media guidance application may detect the presence of a previously recorded segment. After detecting the previously recorded segment, the interactive media guidance application may automatically record the video following the end of the previously recorded segment. The interactive media guidance application may use data associated with the segments and other media cues to match the segments. The interactive media guidance application may also identify the duration of the recorded video content and provide choices for recording the video again.

Abstract: The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

Abstract: The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

Abstract: Systems and methods for providing an interactive media guidance application for merging recorded video segments that are from the same program are provided. In response to a recording interruption, the interactive media guidance application may record multiple video segments. After recording the segments, the interactive media guidance application may search for and merge these segments to form a single recording. In some embodiments, the interactive media guidance application may detect the presence of a previously recorded segment. After detecting the previously recorded segment, the interactive media guidance application may automatically record the video following the end of the previously recorded segment. The interactive media guidance application may use data associated with the segments and other media cues to match the segments. The interactive media guidance application may also identify the duration of the recorded video content and provide choices for recording the video again.

Abstract: Systems and methods for providing an interactive media guidance application for merging recorded video segments that are from the same program are provided. In response to a recording interruption, the interactive media guidance application may record multiple video segments. After recording the segments, the interactive media guidance application may search for and merge these segments to form a single recording. In some embodiments, the interactive media guidance application may detect the presence of a previously recorded segment. After detecting the previously recorded segment, the interactive media guidance application may automatically record the video following the end of the previously recorded segment. The interactive media guidance application may use data associated with the segments and other media cues to match the segments. The interactive media guidance application may also identify the duration of the recorded video content and provide choices for recording the video again.

Abstract: A device provides an ager ring that ages entries associated with managed resource of a device, and determines whether a particular entry associated with a particular managed resource of the device is to be updated. The device also updates, when the particular entry is to be aged out in a particular time frame, the particular entry in the ager ring based on a bucket offset and a current time bucket associated with the particular entry and based on a current time, a refresh timeout, and a maximum timeout associated with the ager ring. The device further updates, when the particular entry is being aged during processing, the particular entry in the ager ring based on a new bucket, the current time bucket, and the bucket offset associated with the particular entry and based on the maximum timeout associated with the ager ring.

Abstract: There is disclosed a recombinant pharmaceutical composition comprising a large plurality of recombinant immunoglobulins made by expression of a wide diversity of antibodies from a recombinant antibody library, preferably obtained from a wide diversity of human sources, synthetic or semi-synthetic germline immunoglobulin sequences, or a combination thereof, and then purified. Mammalian cell expression antibody libraries normally produce antibodies with significant diversity or different antibodies that bind to different targets. There is further disclosed a recombinant pharmaceutical composition made from a mammalian expression library configured to excrete, rather than display their antibodies on the cell surface, and then purified to form the pharmaceutical composition from the excreted antibodies.

Abstract: A device provides an ager ring that ages entries associated with managed resource of a device, and determines whether a particular entry associated with a particular managed resource of the device is to be updated. The device also updates, when the particular entry is to be aged out in a particular time frame, the particular entry in the ager ring based on a bucket offset and a current time bucket associated with the particular entry and based on a current time, a refresh timeout, and a maximum timeout associated with the ager ring. The device further updates, when the particular entry is being aged during processing, the particular entry in the ager ring based on a new bucket, the current time bucket, and the bucket offset associated with the particular entry and based on the maximum timeout associated with the ager ring.

Abstract: A device provides an ager ring that ages entries associated with managed resource of a device, and determines whether a particular entry associated with a particular managed resource of the device is to be updated. The device also updates, when the particular entry is to be aged out in a particular time frame, the particular entry in the ager ring based on a bucket offset and a current time bucket associated with the particular entry and based on a current time, a refresh timeout, and a maximum timeout associated with the ager ring. The device further updates, when the particular entry is being aged during processing, the particular entry in the ager ring based on a new bucket, the current time bucket, and the bucket offset associated with the particular entry and based on the maximum timeout associated with the ager ring.

Abstract: A device provides an ager ring that ages entries associated with managed resource of a device, and determines whether a particular entry associated with a particular managed resource of the device is to be updated. The device also updates, when the particular entry is to be aged out in a particular time frame, the particular entry in the ager ring based on a bucket offset and a current time bucket associated with the particular entry and based on a current time, a refresh timeout, and a maximum timeout associated with the ager ring. The device further updates, when the particular entry is being aged during processing, the particular entry in the ager ring based on a new bucket, the current time bucket, and the bucket offset associated with the particular entry and based on the maximum timeout associated with the ager ring.

Abstract: Provided herein are isolated or synthesized Rhopalosiphum padi virus (RhPV) nucleic acids having promotor activities, and vectors containing the isolated or synthesized RhPV nucleic acids for gene delivery in insect expression systems.