Patents by Inventor Jane Yang
Jane Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240115659Abstract: Both Sp2CBMTD and Vc2CBMTD were shown to reduce the apical viral load of RSV-infected human airway epithelial cells. The degree of reduction was dependent on the type of mCBM and number of doses administered. Exposure of infected MucilAlr inserts to Sp2CBMTD did not show a significant effect on viral replication due to variability of data but a slight reduction was observed at the highest dose (100 ?g) after two doses at 48 h p.i (see FIG. 23A), and after three doses at 96 h p.i. compared to virus infected control. Exposure to Vc2CBMTD (100 ?g) was more effective in reducing RSV viral replication in both dosing regimens than using a 10 ?g dosing regimen. Although not statistically significant, the reduction of viral load at 48 h p.i was observed to decreased greater than 1 log (FIG. 23B).Type: ApplicationFiled: October 12, 2023Publication date: April 11, 2024Inventors: Helen Connaris, Lei Yang, Jane Alexandra Potter
-
Publication number: 20240102022Abstract: Methods and compositions are provided for the treatment of Alzheimer's Disease (AD) by administering to a patient a therapeutically effective amount of an agent that inhibits signaling mediated by a bone morphogenetic protein type 1A receptor (BMPR-1A) or bone morphogenetic protein type 2 receptor (BMPR-2). Also provided are methods and compositions to increase the rate of neural stem cell self-renewal.Type: ApplicationFiled: November 17, 2023Publication date: March 28, 2024Applicants: CZ Biohub SF, LLC, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Elizabeth Yang Chen, Felicia Reinitz, Jane Antony, Michael F. Clarke, Robert C. Jones
-
Patent number: 11939251Abstract: A peritoneal dialysis system includes a cycler including a pump actuator, a heater and a heating pan operable with the heater, and a disposable set operable with the cycler. The heating pan includes a sidewall forming a slot. The disposable set includes a pumping cassette and a heater/mixing container. The pumping cassette includes a pump chamber configured to be actuated by the pump actuator. Additionally, the heater/mixing container is in fluid communication with the pumping cassette and is sized to be received at the heating pan. The heater/mixing container includes a port configured such that when the port is slid into the slot of the heater pan sidewall, the port is prevented from rotating about an axis transverse to a direction of flow through the port.Type: GrantFiled: October 1, 2020Date of Patent: March 26, 2024Assignee: Gambro Lundia ABInventors: Jane E. Fitzgerald, Ryan P. Marry, John S. Norman, James D. Ascenzo, Meng-Yang Chen, Anders Wellings, Edward S. Szpara, Olof Jansson
-
Publication number: 20230330263Abstract: Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).Type: ApplicationFiled: April 7, 2023Publication date: October 19, 2023Inventors: Zhihong Jane YANG, Jaclyn HO, Chris REID, Jin YANG
-
Patent number: 11781156Abstract: Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).Type: GrantFiled: July 30, 2021Date of Patent: October 10, 2023Assignee: TENAYA THERAPEUTICS, INC.Inventors: Zhihong Jane Yang, Jaclyn Ho, Chris Reid, Jin Yang
-
Publication number: 20230056066Abstract: Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).Type: ApplicationFiled: August 5, 2022Publication date: February 23, 2023Inventors: Zhihong Jane YANG, Jaclyn HO, Chris REID, Jin YANG
-
Publication number: 20230051968Abstract: Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).Type: ApplicationFiled: October 6, 2022Publication date: February 16, 2023Inventors: Zhihong Jane YANG, Jaclyn HO, Chris REID, Jin YANG
-
Publication number: 20230041648Abstract: Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).Type: ApplicationFiled: August 5, 2022Publication date: February 9, 2023Inventors: Zhihong Jane YANG, Jaclyn HO, Chris REID, Jin YANG
-
Publication number: 20220112517Abstract: Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).Type: ApplicationFiled: July 30, 2021Publication date: April 14, 2022Inventors: Zhihong Jane YANG, Jaclyn HO, Chris REID, Jin YANG
-
Publication number: 20210239717Abstract: The present disclosure relates to methods of detecting various analytes, including glycated hemoglobin (HbA1c) and total hemoglobin (THb), in a biological sample obtained with a microsampling device.Type: ApplicationFiled: August 21, 2019Publication date: August 5, 2021Applicant: Quest Diagnostics Investments LLCInventors: Nigel Clarke, Mildred Goldman, Jueun Kim, Jane Yang
-
Patent number: 10556900Abstract: The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I): which are tropomyos-in-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.Type: GrantFiled: April 4, 2016Date of Patent: February 11, 2020Assignee: Merck Sharp & Dohme Corp.Inventors: Craig A. Stump, Yi Heng Chen, Ping Liu, Dongfang Meng, Jane Yang Wu, Chun Sing Li, Zhiqi Qi
-
Patent number: 10351558Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.Type: GrantFiled: February 12, 2016Date of Patent: July 16, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Dongfang Meng, Hong Li, Meng Yang, Manuel de Lera Ruiz, Sunita V. Dewnani, Tianying Jian, Dann L. Parker, Jr., Ting Zhang, Louis-Charles Campeau, Harold B. Wood, Jiayi Xu, Richard Berger, Jane Yang Wu, Robert K. Orr, Shawn P. Walsh, Bart Harper
-
Publication number: 20180105518Abstract: The present invention is directed to bicyclic heteroaryl benzamide compounds of formulas (I): which are tropomyos-in-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.Type: ApplicationFiled: April 4, 2016Publication date: April 19, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Craig A. Stump, Yi Heng Chen, Ping Liu, Dongfang Meng, Jane Yang Wu, Chun Sing Li, Zhiqi Qi
-
Publication number: 20180022747Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.Type: ApplicationFiled: February 12, 2016Publication date: January 25, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Dongfang Meng, Hong Li, Meng Yang, Manuel de Lera Ruiz, Sunita V. Dewnani, Tianying Jian, Dann L. Parker, Jr., Ting Zhang, Louis-Charles Campeau, Harold B. Wood, Jiayi Xu, Richard Berger, Jane Yang Wu, Robert K. Orr, Shawn P. Walsh, Bart Harper
-
Patent number: 9657012Abstract: The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.Type: GrantFiled: December 22, 2011Date of Patent: May 23, 2017Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Colleen Hudson, Timothy C. Barden, James Jia, Ara Mermerian, Bo Peng, Jane Yang, Xiang Y. Yu, Kevin Sprott, Angelika Fretzen
-
Publication number: 20150175599Abstract: The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.Type: ApplicationFiled: December 22, 2011Publication date: June 25, 2015Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Colleen Hudson, Timothy C. Barden, James Jia, Ara Mermerian, Bo Peng, Jane Yang, Xiang Y. Yu, Kevin Sprott, Angelika Fretzen
-
Patent number: 8884020Abstract: Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.Type: GrantFiled: August 7, 2007Date of Patent: November 11, 2014Assignee: Ironwood Pharmaceuticals, Inc.Inventors: John Jeffrey Talley, Kevin Sprott, James Philip Pearson, G. Todd Milne, Wayne Schairer, Jane Yang, Charles Kim, Timothy Barden, Regina Lundrigan, Ara Mermerian, Mark G. Currie
-
Publication number: 20130178475Abstract: Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.Type: ApplicationFiled: March 10, 2011Publication date: July 11, 2013Applicant: IRONWOOD PHARMACEUTICALS, INC.Inventors: Joel Moore, James Jia, Takashi Nakai, Charles Kim, Thomas Wai-Ho Lee, Jane Yang
-
Publication number: 20130109721Abstract: The present disclosure relates to N-benzyl pyrrole compounds of formula (I) useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders.Type: ApplicationFiled: December 8, 2010Publication date: May 2, 2013Applicant: Ironwood Pharmaceuticals, Inc.Inventors: Kevin Sprott, John Jeffrey Talley, Jane Yang, Bo Peng
-
Patent number: 7960544Abstract: Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.Type: GrantFiled: December 18, 2006Date of Patent: June 14, 2011Assignee: Ironwood Pharmaceuticals, Inc.Inventors: Wilmin Bartolini, Brian M. Cali, Barbara Chen, Yueh-Tyng Chien, Mark G. Currie, G. Todd Milne, James Philip Pearson, John Jeffrey Talley, Jane Yang, Craig Zimmerman, Charles Kim, Kevin Sprott, Timothy Barden, Regina Lundigran, Ara Mermerian