Abstract: A reusable accessory for a medication delivery device includes a housing, an adaptive element coupled to the housing and configured to reversibly attach to a medication delivery device received in the housing, and one or more attachment sensors configured to detect the adaptive element reversibly attaching to the medication delivery device. A method for detecting a medication delivery device in a reusable accessory includes determining, based on sensing data from one or more attachment sensors, whether the medication delivery device is reversibly attached, via an adaptable element, to a housing of the reusable accessory, and presenting, via at least one user interface, a status of the medication delivery device. A reusable accessory adaption kit comprises a first reusable accessory, a first adaptive element configured for reversibly attaching a first medication delivery device, and a second adaptive element configured for reversibly attaching a second medication delivery device.

Abstract: Medication delivery methods, devices and systems are provided. The medication delivery device includes a retractable sheath mechanism connected to a distal end of the device. The retractable sheath mechanism is axially movable between a first position to cover a needle attached to the distal end and a second position to expose the needle with an adjustable protrusion length. The retractable sheath mechanism includes one or more skin sensors disposed on an end surface thereof to detect skin before and during injection. In some cases, a needle carousel is provided to connect to the distal end of the device. The needle carousel supports multiple needle capsules each including a needle.

Abstract: The present invention relates to a coating comprising a (i) boronic ester of Formula (I) disclosed herein, and (ii) an elastomer, wherein (i) and (ii) are cured with pentaerythritol tetrakis(3-mercaptoptopionate) (PTMP) and 3,6-dioxa-1,8-octanedithiol (DODT).

Abstract: Disclosed herein is a self-healing material comprising microcapsules comprising a monomeric or oligomeric healing agent, and a catalyst that is able to catalyse the polymerisation of the monomeric or oligomeric healing agent.

Abstract: The disclosure addresses methods, compositions, and kits used to detect or quantify polymerase inhibitors in biological samples. The polymerase inhibitors can be therapeutic agents, or metabolites thereof, that have been administered to a subject as part of, for example, antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) to address potential infections by, e.g., retroviruses such as HIV and other viruses reliant on reverse transcription. These methods, compositions, and kits can be applied to monitor a subject's compliance with the indicated therapies and can inform potential adjustments to the therapies.

Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.

Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.

Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.

Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.

Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.

Abstract: There is disclosed a floating system positioned in a body of water having a water bottom, the system comprising a host member floating on a surface of the water; a flotation module floating under the surface of the water; a flexible hose connecting the host member to the flotation module; and an elongated underwater line structure, comprising a top portion connected to the flotation module; a bottom portion extending to the water bottom and adapted to connect to a flowline lying on the water bottom; and at least one of the top portion and the bottom portion comprising a catenary configuration.

Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.

Abstract: The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.

Abstract: This invention relates generally to films having barrier as well as controlled disintegration properties and, more particularly, to controlled water disintegrable films.

Abstract: This invention relates generally to films having barrier as well as controlled disintegration properties and, more particularly, to controlled water disintegrable films.

Abstract: Processes for chemical conversion of volatile organic compounds to value added products using multiphasic membrane reactors are described. More particularly the multiphasic materials comprising two or more phases bound to one another which in the form of a solid state membrane demonstrate an ability to selectively convey electrons, hydrogen and oxygen between different gaseous mixtures. Characteristics of such multiphasic materials provide independent, controllable, counter-current transport of hydrogen, electrons and oxygen.

Abstract: Preparation, structure, and properties of non-homogenous solid systems, which in the form of a solid state membrane demonstrate an ability to selectively convey electrons, hydrogen and oxygen between different gaseous mixtures, and their uses, are described. Multiphasic systems of the invention comprising two or more phases bound to one another, and at least one of the bound phases demonstrates an ability to selectively convey hydrogen, another phase demonstrates an ability to selectively convey oxygen ions between different gaseous mixtures, and one or more phase demonstrates electronic conductivity.