Patents by Inventor Janendra Batra

Janendra Batra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin
    Patent number: 6099842
    Abstract: Single chain immunotoxins directed at the human transferrin receptor using PCR based methods are described. Anti-TFR(Fv)-PE40 contains DNA for the antigen binding portion (Fv) of a monoclonal antibody directed at the human transferrin receptor fused to the DNA for a 40,000 molecular weight fragment of Pseudomonas exotoxin (PE40). In another fusion protein, DT388-anti-TFR(Fv), DNA for the antigen binding portions of the anti-TFR antibody has been fused to the DNA encoding a truncated form of Diphtheria toxin. In anti-TFR(Fv)-PE40, the single chain antibody precedes the toxin whereas in DT388-anti-TFR(Fv) the single chain antibody is at the carboxyl end of toxin. The proteins encoded by these gene fusions were expressed in E.coli and purified by conventional chromatographic techniques to near homogeneity.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: August 8, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ira Pastan, Vijay Chaudhary, David FitzGerald, Janendra Batra