Abstract: Provided herein are compounds that modulate RMB39 and methods of using the compounds in RMB39-associated disorders, such as cancer (e.g., renal cell carcinoma).

Abstract: A foldable beach chair mat includes two chair support pads, each comprising a respective rigid planar body. An elongated edge of the first rigid planar body has a first semicircular aperture comprising a first concave end face, and a corresponding elongated edge of the second rigid planar body has a second semicircular aperture comprising a second concave end face. An elongated hinge is positioned between and pivotally connects the elongated edges, to pivot and fold the first rigid planar body towards the second rigid planar body to a face-to-face abutment, to fold the mat. In an extended position, the first rigid planar body and the second rigid planar body are coplanar. The mat includes a carry strap for carrying the mat in a folded state and also has a retention strap for maintaining the folded state. A plurality of cupholders are defined by the rigid planar bodies for accommodating beverage containers.

Abstract: The present disclosure provides for a game ball for educational learning related play having a spherical body where the body has a plurality of flat exterior surfaces. The plurality of flat exterior surfaces include a plurality of groupings of three adjacent exterior flat surfaces. Each flat exterior surface of each of the groupings respectively have a flat flexible transparent pouch. Each flat flexible transparent pouch has a first slot opening opposite a second slot opening, and each flat flexible transparent pouch is respectively sized and configured to removably receive and secure an interchangeable educational index card in an installed position.

Abstract: A matrix for aggregate containment and drainage system for road-base construction, or reconstruction--provides by reuse of vehicle tires. Each tire (unit) has one sidewall removed and drain holes provided in the remaining sidewall. A plurality of these units are positioned and fastened together to form a matrix. Each unit open side up, lying flat then receives aggregate construction material. The matrix configuration provides an excellent base for construction, minimizing aggregate loss due to sinking, wash out or lateral movement. A major ecological advantage is the beneficial use of otherwise problem used tires.