Patents by Inventor Janet C. Onishi

Janet C. Onishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding 1,3 beta-D glucan synthase subunits
    Patent number: 5821353
    Abstract: DNA molecules encoding proteins involved in biosynthesis of 1,3-beta-D glucan are identified, cloned, expressed and used in in vitro assays to screen for antifungal compounds, including compounds that affect cell wall biosynthesis. The invention includes but is not limited to the purified DNA molecules, assays employing the DNA molecules, proteins encoded by the DNA molecules, cells expressing the DNA molecules and altered forms of the molecules.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: October 13, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Cameron M. Douglas, Gary L. Chrebet, Joseph Clemas, Mohammed El-Sherbeini, Forrest Foor, Jennifer Nielsen Kahn, Rosemarie Kelly, Jean A. Marrinan, Nancy R. Morin, Janet C. Onishi, Stephen Authur Parent, Naasa M. Ramadan, Elizabeth A. Register, Gan-Ju Shei
  • Antifungal agent obtained from hormonema
    Patent number: 5756472
    Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: May 26, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Jerrold M. Liesch, Maria S. Meinz, Janet C. Onishi, Sandra A. Morris, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Wendy S. Horn, Deborah L. Zink, Angeles Cabello, Maria T. Diez, Isabella Martin, Fernando Pelaez, Francisca Vicente
  • Antifungal agent produced by arthrinium arundinis ATCC 74359
    Patent number: 5712109
    Abstract: There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: January 27, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Jerrold M. Liesch, Maria S. Meinz, Janet C. Onishi, Robert E. Schwartz, Gerald F. Bills, Robert A. Giacobbe, Deborah L. Zink, Angeles Cabello, Maria T. Diez, Isabella Martin, Fernando Pelaez, Francisca Vicente
  • Antifungal agents
    Patent number: 5597806
    Abstract: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: January 28, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Wendy H. Clapp, Guy H. Harris, Gerald F. Bills, James E. Curotto, Anne W. Dombrowski, Sarah J. Driekorn, Myra B. Kurtz, Maria S. Meinz, Janet C. Onishi, Jon D. Polishook, Stanley L. Streicher, John R. Thompson, Marie Williams, Deborah L. Zink
  • Antifungal compound and compositions containing the compound
    Patent number: 5348970
    Abstract: A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: September 20, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, Janet C. Onishi, Gerald F. Bills, Robert A. Giacobbe, Fernando Pelaez, Maria T. Diez, Francisca Vicente, Julian Gorrochategui, Gregory L. Helms, Barnali Pramanik
  • Fungicidal compositions and method
    Patent number: 5214067
    Abstract: Novel fungicidal compositions comprising a pyranyl glycine ester compound and a .beta.-lactone compound and a method for controlling mycotic infections is disclosed.
    Type: Grant
    Filed: September 17, 1990
    Date of Patent: May 25, 1993
    Assignee: Merck & Co., Inc.
    Inventor: Janet C. Onishi
  • Squalene synthetase inhibitors
    Patent number: 5132320
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: July 21, 1992
    Assignee: Merck & Co., Inc.
    Inventors: James D. Bergstrom, Otto D. Hensens, Claude Dufresne, Leeyuan Huang, Janet C. Onishi, Deborah L. Zink
  • Novel squalene synthetase inhibitors
    Patent number: 5102907
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: April 7, 1992
    Assignee: Merck & Co., Inc.
    Inventors: James D. Bergstrom, Claude Dufresne, Leeyuan Huang, Mary Nallin, Janet C. Onishi
  • Novel squalene synthetase inhibitors
    Patent number: 5096923
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: March 17, 1992
    Assignee: Merck & Co., Inc.
    Inventors: James D. Bergstrom, Otto D. Hensens, Leeyuan Huang, Jerrold M. Liesch, Janet C. Onishi, Frank L. Vanmiddlesworth
  • Novel HMG-CoA synthase inhibitors
    Patent number: 5064856
    Abstract: Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: November 12, 1991
    Assignee: Merck & Co., Inc.
    Inventors: George M. Garrity, Robert Giacobbe, Michael D. Greenspan, Otto D. Hensens, Henry Joshua, Maria T. D. Matas, Isabel Martin, James A. Milligan, Sagrario M. del Val, Walter Rozdilsky, Janet C. Onishi, Jerrold M. Liesch
  • Novel anti-fungal compounds
    Patent number: 5055487
    Abstract: This invention relates to a method of inhibiting fungal growth by employing an antifungal amount of a compound of formula (I): ##STR1##
    Type: Grant
    Filed: December 11, 1990
    Date of Patent: October 8, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth F. Bartizal, James A. Milligan, Walter Rozdilsky, Janet C. Onishi
  • Novel anti-fungal compounds
    Patent number: 5053425
    Abstract: This invention relates to a method of inhibiting fungal growth by employing an antifungal amount of a compound of formula (I): ##STR1##
    Type: Grant
    Filed: December 11, 1990
    Date of Patent: October 1, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth F. Bartizal, Walter Rozdilsky, Janet C. Onishi
  • Method of inhibiting fungal growth using squalene synthetase inhibitors
    Patent number: 5026554
    Abstract: This invention relates to a method of inhibiting fungal growth by employing an antifungal amount of a compound of formula (I): ##STR1##
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: June 25, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth F. Bartizal, Janet C. Onishi
  • Fungicidal compositions and method
    Patent number: 4988697
    Abstract: Novel fungicidal compositions comprising a 14.alpha.-methyldemethylase inhibiting azole compound and a .beta.-lactone compound and a method for controlling mycotic infections is disclosed.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: January 29, 1991
    Assignee: Merck & Co., Inc.
    Inventor: Janet C. Onishi
  • Fungicidal compositions and method
    Patent number: 4921844
    Abstract: Novel fungicidal compositions comprising a 25-azasterol composition and a .beta.-ketothiolase inhibitor compound are disclosed.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: May 1, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Arthur A. Patchett
  • Fungicidal compositions and method
    Patent number: 4920112
    Abstract: Novel fungicidal compositions comprising a 25-azasterol compound and a squalene epoxidase inhibitor compound are disclosed.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: April 24, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Arthur A. Patchett
  • Fungicidal compositions and methods utilizing 25-azasterol and HMG-CoA synthase inhibitors
    Patent number: 4920113
    Abstract: Novel fungicidal compositions comprising a 25-azasterol compound and a HMG-CoA synthase inhibitor compound are disclosed.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: April 24, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Arthur A. Patchett
  • Antifungal compositions and method of controlling mycotic infections
    Patent number: 4920109
    Abstract: Method of potentiating antifungal agents with 25-azasterol compound to produce superior antifungal compositions and use of the compositions to control mycotic infections is disclosed.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: April 24, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Arthur A. Patchett
  • Fungicidal compositions and methods utilizing 25-azasterol and HMG-CoA reductase inhibitors
    Patent number: 4920111
    Abstract: Novel fungicidal composition comprising a 25-azasterol compound and a HMG-CoA reductase inhibitor compound are disclosed.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: April 24, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Arthur A. Patchett
  • Antifungal fermentation product and derivatives and compositions thereof
    Patent number: 4847284
    Abstract: A novel pyrrolidinol isolated from the fermentation of Aspergillus ochraceus and certain derivatives thereof are described. The compounds are broad spectrum antifungal agents.
    Type: Grant
    Filed: March 23, 1988
    Date of Patent: July 11, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, Janet C. Onishi, Richard L. Monaghan, Jerrold M. Liesch, Otto D. Hensens