Abstract: A flexible rule engine allows a network operator to dynamically create and modify business rules that govern a subscriber's access to a communications network. The flexible rule engine governs subscriber transitions between various session states by testing for subscriber conditions, network conditions, and then performing specified actions based on these conditions. A rule editor provides the network operator with the ability to compose, edit and delete one or more rules in real time, using an appropriate user interface.

Abstract: A flexible rule engine allows a network operator to dynamically create and modify business rules that govern a subscriber's access to a communications network. The flexible rule engine governs subscriber transitions between various session states by testing for subscriber conditions, network conditions, and then performing specified actions based on these conditions. A rule editor provides the network operator with the ability to compose, edit and delete one or more rules in real time, using an appropriate user interface.

Abstract: The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, anxiety, depression resulting from an estrogen deficiency, inflammation, inflammatory bowel disease, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.

Abstract: A method for identifying analytes which directly or indirectly affect tryptophan hydroxylase isoform 2 (TPH2) expression is described. The method enables glucocorticoid receptor modulators and &bgr;-hydroxysteroid dehydrogenase type 1 (&bgr,-HSD1) inhibitors to be screened for central nervous system penetrance and activity by determining their ability to regulate expression of TPH2. The method is particularly useful for identifying analytes which suppress glucocorticoid disruption of central serotonergic neurotransmission in the brain.

Abstract: The present invention relates to methods of evaluation and detection of the expression of tryptophan hydroxylase (TPH) gene and induction of TPH by estrogen receptor-beta (ER?) agonists, utilizing TPH riboprobe and/or primers.

Abstract: DNA encoding a novel human GABAB receptor subunit, HG20, as well as the protein encoded by the DNA, is provided. Also provided is DNA encoding a novel murine GABAB receptor subunit, GABABR1a, as well as the protein encoded by the DNA. Heterodimers of HG20 protein and GABABR1a protein that form a functional GABAB receptor are disclosed. Methods of identifying agonists and antagonists of the GABAB receptor are also provided.