Patents by Inventor Janet Cunningham

Janet Cunningham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING PARKINSON'S DISEASE USING VIRAL VECTORS
    Publication number: 20180243249
    Abstract: Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The rAAV virions include a nucleic acid sequence encoding a therapeutic polypeptide. The methods can be used for treating CNS disorders such as for treating Parkinson's Disease.
    Type: Application
    Filed: October 10, 2017
    Publication date: August 30, 2018
    Applicants: Genzyme Corporation, The Regents of the University of California
    Inventors: Krystof Bankiewicz, Janet Cunningham
  • Methods of treating Parkinson's disease using viral vectors
    Patent number: 9492415
    Abstract: Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The rAAV virions include a nucleic acid sequence encoding a therapeutic polypeptide. The methods can be used for treating CNS disorders such as for treating Parkinson's Disease.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: November 15, 2016
    Assignees: Genzyme Corporation, The Regents of the University of California
    Inventors: Krystof Bankiewicz, Janet Cunningham
  • METHODS OF TREATING PARKINSON'S DISEASE USING VIRAL VECTORS
    Publication number: 20160256534
    Abstract: Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The rAAV virions include a nucleic acid sequence encoding a therapeutic polypeptide. The methods can be used for treating CNS disorders such as for treating Parkinson's Disease.
    Type: Application
    Filed: March 25, 2016
    Publication date: September 8, 2016
    Applicants: Genzyme Corporation, The Regents of the University of California
    Inventors: Krystof Bankiewicz, Janet Cunningham
  • METHODS OF TREATING PARKINSON'S DISEASE USING VIRAL VECTORS
    Publication number: 20130101510
    Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
    Type: Application
    Filed: October 8, 2012
    Publication date: April 25, 2013
    Applicants: The Regents of the University of California, Genzyme Corporation
    Inventors: Krys BANKIEWICZ, Janet Cunningham
  • Methods of treating Parkinson's disease using viral vectors
    Patent number: 8309355
    Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the central nervous system (CNS) are provided for the treatment of CNS disorders, particularly those disorders which involve the neurotransmitter dopamine. The methods entail providing rAAV virions that comprise a transgene encoding aromatic amino acid decarboxylase (AADC) and administering the virions to the brain of a mammal using a non-manual pump.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: November 13, 2012
    Assignees: Genzyme Corporation, The Regents of the University of California
    Inventors: Krys Bankiewicz, Janet Cunningham
  • Methods of treating Parkinson's disease using viral vectors
    Publication number: 20100104537
    Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
    Type: Application
    Filed: April 10, 2009
    Publication date: April 29, 2010
    Applicants: Regents of the University of California, Genzyme Corporation
    Inventors: Krys Bankiewicz, Janet Cunningham
  • Methods of treating parkinson's disease using viral vectors
    Patent number: 7534613
    Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: May 19, 2009
    Assignees: Genzyme Corporation, The Regents of the University of California
    Inventors: Krys Bankiewicz, Janet Cunningham
  • Use of recombinant adeno-associated virus vector (rAAV) for the prevention of smooth muscle cell proliferation in a vascular graft
    Publication number: 20060099183
    Abstract: A recombinant adeno-associated virus is used to transduce the cells of a tissue graft ex vivo. More specifically, rAAV encoding a therapeutic protein is delivered to a vascular graft to prevent smooth muscle cell proliferation or thrombosis in the graft. The cells are transfected ex vivo with the recombinant virus carrying a gene known to inhibit the proliferation and migration of vascular smooth muscle cells, thrombosis, and atherosclerosis. The methods can be used for the treatment of restenosis, vascular thrombosis, balloon injury or other vascular pathology.
    Type: Application
    Filed: December 15, 2005
    Publication date: May 11, 2006
    Inventors: Pierre Zoldhelyi, Janet Cunningham, James Willerson
  • Methods of treating central nervous system disorders using viral vectors
    Patent number: 6953575
    Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: October 11, 2005
    Assignees: Avigen, Inc., The Regents of the University of California
    Inventors: Krys Bankiewicz, Janet Cunningham, Jamie L. Eberling
  • Methods of treating parkinson's disease using viral vectors
    Publication number: 20050180955
    Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
    Type: Application
    Filed: April 8, 2005
    Publication date: August 18, 2005
    Applicants: Regents of the University of California, Avigen, Inc.
    Inventors: Krys Bankiewicz, Janet Cunningham, Jamie Eberling
  • Ecdysone-inducible adeno-associated virus expression vectors
    Publication number: 20040087028
    Abstract: The present invention relates to AAV expression vectors that allow the introduction and regulated expression of heterologous genes into mammalian tissues and cells. In certain embodiments, vectors of the present invention are ecdysone-inducible AAV expression vectors and AAV expression vectors encoding EcR and RXR. In this system, the heterologous gene is “turned off” until an inducer such as pon A is provided to the tissues or cells. The present invention also provides methods of using inducible AAV expression vectors.
    Type: Application
    Filed: September 24, 2003
    Publication date: May 6, 2004
    Applicant: Avigen Inc.
    Inventor: Janet Cunningham
  • Use of recombinant adeno-associated virus vector (rAAV) for the prevention of smooth muscle cell proliferation in a vascular graft
    Publication number: 20020192188
    Abstract: A recombinant adeno-associated virus is used to transduce the cells of a tissue graft ex vivo. More specifically, rAAV encoding a therapeutic protein is delivered to a vascular graft to prevent smooth muscle cell proliferation or thrombosis in the graft. The cells are transfected ex vivo with the recombinant virus carrying a gene known to inhibit the proliferation and migration of vascular smooth muscle cells, thrombosis, and atherosclerosis. The methods can be used for the treatment of restenosis, vascular thrombosis, balloon injury or other vascular pathology.
    Type: Application
    Filed: August 7, 2002
    Publication date: December 19, 2002
    Inventors: Pierre Zoldhelyi, Janet Cunningham, James T. Willerson
  • Convection-enhanced delivery of AAV vectors
    Publication number: 20020141980
    Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
    Type: Application
    Filed: June 21, 2001
    Publication date: October 3, 2002
    Applicant: The Regents of the University of California
    Inventors: Krys Bankiewicz, Janet Cunningham, Jamie L. Eberling
  • Methods of treating Parkinson's disease using recombinant adeno-associated vector (rAAV)
    Patent number: 6309634
    Abstract: Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
    Type: Grant
    Filed: June 26, 1999
    Date of Patent: October 30, 2001
    Assignees: Avigen, Inc., The Regents of the University of California
    Inventors: Krys Bankiewicz, Janet Cunningham