Patents by Inventor Janet Davis
Janet Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10351820Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: GrantFiled: March 13, 2017Date of Patent: July 16, 2019Assignee: Janssen Biotech, Inc.Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain Andre Bonnet
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Patent number: 10233421Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: GrantFiled: March 13, 2017Date of Patent: March 19, 2019Assignee: Janssen Biotech, Inc.Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain Andre Bonnet
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Publication number: 20180127723Abstract: The present invention provides a method for treating human pluripotent cells. In particular, the methods of the invention are directed to the treatment of human pluripotent cells, whereby the human pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of glycogen synthase kinase 3? (GSK-3B) enzyme activity.Type: ApplicationFiled: December 18, 2017Publication date: May 10, 2018Applicant: Janssen Biotech, Inc.Inventors: Janet Davis, Jiajian Liu
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Patent number: 9845460Abstract: The present invention is provides a method for treating human pluripotent cells. In particular, the methods of the invention are directed to the treatment of human pluripotent cells, whereby the human pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of glycogen synthase kinase 3? (GSK-3B) enzyme activity.Type: GrantFiled: November 20, 2013Date of Patent: December 19, 2017Assignee: Janssen Biotech, Inc.Inventors: Janet Davis, Jiajian Liu
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Publication number: 20170183625Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: ApplicationFiled: March 13, 2017Publication date: June 29, 2017Applicant: Janssen Biotech, Inc.Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain Andre Bonnet
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Publication number: 20170183624Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: ApplicationFiled: March 13, 2017Publication date: June 29, 2017Applicant: Janssen Biotech, Inc.Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain Andre Bonnet
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Patent number: 9593305Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: GrantFiled: March 29, 2012Date of Patent: March 14, 2017Assignee: Janssen Biotech, Inc.Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain André Bonnet
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Patent number: 9593306Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: GrantFiled: March 29, 2012Date of Patent: March 14, 2017Assignee: Janssen Biotech, Inc.Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain André Bonnet
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Patent number: 9133439Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to increase the expression of NGN3 and NKX6.1 in populations of cells expressing markers characteristic of the pancreatic endocrine lineage.Type: GrantFiled: December 16, 2010Date of Patent: September 15, 2015Assignee: Janssen Biotech, Inc.Inventors: Janet Davis, Christine Parmenter, Kevin Ditolvo
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Publication number: 20140080210Abstract: The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity.Type: ApplicationFiled: November 20, 2013Publication date: March 20, 2014Applicant: JANSSEN BIOTECH, INC.Inventors: Janet Davis, Jiajian Liu
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Patent number: 8623648Abstract: The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity.Type: GrantFiled: April 24, 2008Date of Patent: January 7, 2014Assignee: Janssen Biotech, Inc.Inventors: Janet Davis, Jiajian Liu
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Publication number: 20130337564Abstract: The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity.Type: ApplicationFiled: June 13, 2013Publication date: December 19, 2013Inventors: Janet Davis, Jiajian Liu
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Patent number: 8309197Abstract: Devices, systems and methods for fabricating improved ceramic composite turbine shrouds with abradable seals are disclosed. A high temperature seal with an abradable coating is provided. The seal comprises a three-dimensional, high-density woven composite base structure recessed below the abradable coating, with loops incorporated in and protruding from the base structure. The abradable coating is integrally attached to the base structure via the loops. Additionally, a graded density seal is provided with a three-dimensional, low-density woven composite structure. The low-density structure is abradable. A three-dimensional, high-density woven composite base structure is recessed below the low-density structure, with the low-density structure integrally attached to the base structure via weaving.Type: GrantFiled: December 17, 2008Date of Patent: November 13, 2012Assignee: Teledyne Scientific & Imaging, LLCInventors: Janet Davis, David Marshall, Olivier Sudre
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Publication number: 20120196365Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: ApplicationFiled: March 29, 2012Publication date: August 2, 2012Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain Andrè Bonnet
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Publication number: 20120190111Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: ApplicationFiled: March 29, 2012Publication date: July 26, 2012Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain André Bonnet
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Publication number: 20120190112Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: ApplicationFiled: March 29, 2012Publication date: July 26, 2012Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain André Bonnet
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Publication number: 20110151561Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to increase the expression of NGN3 and NKX6.1 in populations of cells expressing markers characteristic of the pancreatic endocrine lineage.Type: ApplicationFiled: December 16, 2010Publication date: June 23, 2011Inventors: JANET DAVIS, CHRISTINE PARMENTER, KEVIN DITOLVO
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Publication number: 20110091971Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. The present invention also provides methods to generate and purify agents capable of differentiating pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: ApplicationFiled: June 29, 2009Publication date: April 21, 2011Inventors: Janet Davis, Jiajian Liu, Gopalan Raghunathan, Michael Joseph Hunter, Jose Pardinas, Judith Ann Connor, Ronald Vernon Swanson, Ellen Chi
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Publication number: 20100151183Abstract: Devices, systems and methods for fabricating improved ceramic composite turbine shrouds with abradable seals are disclosed. A high temperature seal with an abradable coating is provided. The seal comprises a three-dimensional, high-density woven composite base structure recessed below the abradable coating, with loops incorporated in and protruding from the base structure. The abradable coating is integrally attached to the base structure via the loops. Additionally, a graded density seal is provided with a three-dimensional, low-density woven composite structure. The low-density structure is abradable. A three-dimensional, high-density woven composite base structure is recessed below the low-density structure, with the low-density structure integrally attached to the base structure via weaving.Type: ApplicationFiled: December 17, 2008Publication date: June 17, 2010Inventors: Janet Davis, David Marshall, Olivier Sudre
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Publication number: 20100015711Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.Type: ApplicationFiled: June 30, 2009Publication date: January 21, 2010Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain André Bonnet