Patents by Inventor Janet K. Epp

Janet K. Epp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Globins containing binding domains
    Patent number: 6218513
    Abstract: The present invention relates to globins containing non-naturally occurring binding domains, In particular, the present invention is directed toward a binding domain comprising the oligomerizing domain GCN4 and GCN4 derivatives. Thc present invention also relates to multimeric hemoglobins comprised of at least one globin containing at least one non-naturally occurring binding domain.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: April 17, 2001
    Assignee: Baxter Biotech Technology Sarl
    Inventors: Spencer J. Anthony-Cahill, Janet K. Epp, Bruce A. Kerwin, Peter O. Olins, Antony J. Mathews
  • Modified hemoglobin-like compounds and methods of purifying same
    Patent number: 6150506
    Abstract: The present invention relates to modified hemoglobin-like polypeptides containing multiple dialpha (or dibeta) domains. The present invention also relates to multimeric hemoglobin-like proteins comprising covalently joined hemoglobin-like moieties. Another aspect of the inention is directed at a purification method of hemoglobin-like polypeptides utilizing ion exchange chromatography.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: November 21, 2000
    Assignee: Baxter Biotech Technology Sarl
    Inventors: Stephen P. Trimble, Antony J. Mathews, Bruce A. Kerwin, David A. Marquardt, Spencer Anthony-Cahill, Janet K. Epp, Dominic G. Madril, David C. Anderson
  • Recombinant DNA vectors encoding a 4"-O-isovaleryl acylase derived from a carbomycin biosynthetic gene, designated carE, for use in streptomyces and other organisms
    Patent number: 5068189
    Abstract: The carE gene of Streptomyces thermotolerans has been isolated and used to construct recombinant DNA expression vectors. The carE gene encodes 4"-O-isovaleryl acylase activity important in the biosynthesis of a number of useful antibiotics. The carE gene can be used not only to construct recombinant cells with an increased ability to produce the acylase enzyme but also to construct recombinant cells with the ability to produce novel antibiotic compounds.
    Type: Grant
    Filed: May 13, 1988
    Date of Patent: November 26, 1991
    Assignee: Eli Lilly and Company
    Inventors: Janet K. Epp, Brigitte E. Schoner
  • Carbomycin biosynthetic gene, designated carG, for use in streptomyces and other organisms
    Patent number: 4952502
    Abstract: The carG gene of Streptomyces thermotolerans has been isolated and used to construct recombinant DNA expression vectors. The carG gene encodes the activities required for the biosynthesis of the 16-member cyclic lactone of carbomycin. The carG gene can be used not only to construct recombinant cells with an increased ability to produce carbomycin but also to construct recombinant cells with the ability to produce novel antibiotic compounds.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: August 28, 1990
    Assignee: Eli Lilly and Company
    Inventors: Janet K. Epp, Brigitte E. Schoner
  • Carbomycin resistance-conferring gene, designated carb, for use in streptomyces and other organisms
    Patent number: 4914030
    Abstract: The carB gene is a novel carbomycin resistance-conferring gene isolated from Streptomyces thermotolerans and used to construct a number of cloning vectors for use in Streptomyces and related organisms. One such coloning vector, plasmid pOJ159, can be obtained in S. griseofuscus C581 under the accession number NRRL 18090. S. lividans and S. griseofuscus are the preferred hosts when the carB gene is used to select carbomycin-resistant Streptomyces transformants.
    Type: Grant
    Filed: August 28, 1986
    Date of Patent: April 3, 1990
    Assignee: Eli Lilly and Company
    Inventors: Brigitte E. Schoner, Janet K. Epp
  • Carbomycin resistance-conferring gene, designated cara, for use in streptomyces and other organisms
    Patent number: 4904591
    Abstract: The carA gene is a novel carbomycin resistance-conferring gene isolated from Streptomyces thermotolerans and used to construct a number of cloning vectors for use in Streptomyces and related organisms. One such cloning vector, plasmid pOJ158, can be obtained in S. griseofuscus C581 under the accession number NRRL 18089. S. lividans and S. griseofuscus are the preferred hosts when the carA gene is used to select carbomycin-resistant Streptomyces transformants.
    Type: Grant
    Filed: August 28, 1986
    Date of Patent: February 27, 1990
    Assignee: Eli Lilly and Company
    Inventors: Janet K. Epp, Brigitte E. Schoner
  • Derivative of the tryptophan operon for expression of fused gene products
    Patent number: 4738921
    Abstract: The present invention comprises improved derivatives of the tryptophan operon useful for expressing fused gene products in E. coli and relate organism. Two of the improved derivatives disclosed are encoded on 0.43 and 0.55 kb EcoRI restriction fragments from plasmids pCZ20 and pLEBGH2 (in strains NRRL B-15881 and NRRL B-15882), respectively. The modified derivatives have been placed on recombinant DNA cloning and expression vectors. A variety of expression vectors have been constructed that drive expression of fused gene products. Two novel gene sequences, encoding insulin-like growth factors I and II, have been expressed with the modified tryptophan operon system.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: April 19, 1988
    Assignee: Eli Lilly and Company
    Inventors: Ramamoorthy Belagaje, Janet K. Epp, JoAnn Hoskins, Hansen M. Hsiung, George L. Long, Brigitte E. Schoner