Patents by Inventor Janet L. Smith

Janet L. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SINGLE-CHAIN ANTIBODY AGAINST FLAVIVIRUS NS1 PROTEIN
    Publication number: 20240002479
    Abstract: The disclosure is directed to binding agents, e.g., a single chain variable fragment (scFv) that specifically binds to a flavivirus NS1 protein, as well as compositions comprising the binding agent and a method of using such compositions to induce an immune response against a flavivirus (e.g., a dengue virus). The disclosure also provides a conjugate comprising the binding agent, and a recombinant NS1 antigen.
    Type: Application
    Filed: November 23, 2021
    Publication date: January 4, 2024
    Inventors: Janet L. Smith, David L. Akey, William Clay Brown, Eva Harris, Scott B. Biering, P. Robert Beatty
  • Vaccine compositions and uses thereof
    Patent number: 10046045
    Abstract: The present disclosure relates to nonstructural protein 1 (NS1) from flaviviruses and uses thereof. In particular, the present invention relates to diagnostic and therapeutic uses of NS1 to treat and prevent disease caused by flaviviruses.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: August 14, 2018
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, PURDUE RESEARCH FOUNDATION
    Inventors: Janet L. Smith, David L. Akey, W. Clay Brown, Richard J Kuhn
  • VACCINE COMPOSITIONS AND USES THEREOF
    Publication number: 20160317644
    Abstract: The present disclosure relates to nonstructural protein 1 (NS1) from flaviviruses and uses thereof. In particular, the present invention relates to diagnostic and therapeutic uses of NS1 to treat and prevent disease caused by flaviviruses.
    Type: Application
    Filed: December 19, 2014
    Publication date: November 3, 2016
    Inventors: Janet L. SMITH, David L. AKEY, W. Clay BROWN, Richard J KUHN
  • Method for enzymatic production of decarboxylated polyketides and fatty acids
    Patent number: 8765431
    Abstract: Disclosed herein are methods of preparing alkenes from beta-hydroxy or beta-sulfate carboxylic acid or carboxylic acid derivatives using thioesterase and optionally a sulfotransferase.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: July 1, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: David H. Sherman, Janet L. Smith, Liangcai Gu, Jennifer Gehret
  • METHOD FOR ENZYMATIC PRODUCTION OF DECARBOXYLATED POLYKETIDES AND FATTY ACIDS
    Publication number: 20110091952
    Abstract: Disclosed herein are methods of preparing alkenes from beta-hydroxy or beta-sulfate carboxylic acid or carboxylic acid derivatives using thioesterase and optionally a sulfotransferase.
    Type: Application
    Filed: July 23, 2010
    Publication date: April 21, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David H. Sherman, Janet L. Smith, Liangcai Gu, Jennifer Gehret
  • Deregulation of glutamine PRPP amidotransferase activity
    Publication number: 20030166166
    Abstract: The present invention is directed methods of purine synthesis using a modified amidotransferase, wherein the modified glutamine PRPP amidotransferase has reduced sensitivity to end-product inhibition of synthesizing purine nucleotides.
    Type: Application
    Filed: April 3, 2003
    Publication date: September 4, 2003
    Inventors: Howard Zalkin, Janet L. Smith, Robert L. Switzer
  • Deregulation of glutamine PRPP amidotransferase activity
    Patent number: 6586216
    Abstract: The present invention is directed to a modified amidotransferase. The amino acid sequence of the modified amidotransferase differs from the amino acid sequence of a native E. coli glutamine PRPP amidotransferase in that one or more amino acid residues of the modified amidotransferase are substituted at positions equivalent to amino acid positions in Bacillus amidotransferase selected from the group consisting of 282, 283, 307, and 347 of SEQ ID NO:1, wherein the modified amidotransferase is less sensitive to end-product inhibition than is the native E. coli glutamine PRPP amidotransferase.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: July 1, 2003
    Assignees: Purdue Research Foundation, The Board of Trustees of the University of Illinois
    Inventors: Howard Zalkin, Janet L. Smith, Robert L. Switzer
  • Deregulation of glutamine PRPP amidotransferase activity
    Publication number: 20010031486
    Abstract: The present invention is directed to a modified glutamine PRPP amidotransferase and a method of using that modified enzyme to enhance the biosynthesis of purine nucleotides. The modified glutamine PRPP amidotransferase has at least one amino acid of the allosteric A sites or the catalytic C sites of said amidotransferase substituted with a non-native amino acid, wherein the substitution reduces the sensitivity of the enzyme to end product inhibition relative to the native glutamine PRPP amidotransferase enzyme.
    Type: Application
    Filed: March 13, 2001
    Publication date: October 18, 2001
    Inventors: Howard Zalkin, Janet L. Smith, Robert L. Switzer