Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

Abstract: Disclosed is a method of making an integrally bladed rotor. According to the method, a rotor disk comprising a radially outer rim surface is provided. A portion of the disk outer rim surface is removed, leaving a protrusion on the rotor disk outer rim surface. The disk with material removed is subjected to thermal processing. A blade comprising an airfoil and a base is positioned such that a base surface is in contact with the protrusion, and heat, pressure, and motion are applied between the blade and the disk to friction weld the base surface to the protrusion.

Abstract: Disclosed is a method of making an integrally bladed rotor. According to the method, a titanium alloy rotor disk with 15-50% by volume of primary alpha grains with a grain size less than 10 ?m and secondary alpha grains comprising widmanstatten grains with a grain size less than 1.0 ?m is subjected to thermal processing. After thermal processing, a blade having an airfoil and a base is positioned such that a base surface is in contact with an outer rim surface of the disk. Heat, pressure, and motion are applied between the blade and the disk to friction weld the base surface to the disk outer rim surface.

Abstract: Disclosed is a method of making an integrally bladed rotor. According to the method, a titanium alloy rotor disk with 15-50% by volume of primary alpha grains with a grain size less than 10 ?m and secondary alpha grains comprising widmanstatten grains with a grain size less than 1.0 ?m is subjected to thermal processing. After thermal processing, a blade having an airfoil and a base is positioned such that a base surface is in contact with an outer rim surface of the disk. Heat, pressure, and motion are applied between the blade and the disk to friction weld the base surface to the disk outer rim surface.

Abstract: Disclosed is a method of making an integrally bladed rotor. According to the method, a rotor disk comprising a radially outer rim surface is provided. A portion of the disk outer rim surface is removed, leaving a protrusion on the rotor disk outer rim surface. The disk with material removed is subjected to thermal processing. A blade comprising an airfoil and a base is positioned such that a base surface is in contact with the protrusion, and heat, pressure, and motion are applied between the blade and the disk to friction weld the base surface to the protrusion.

Abstract: The present invention relates to a method for fabricating an integrally bladed rotor which comprises providing a hub section, preferably formed from a titanium based alloy, and welding an airfoil, also preferably formed from a titanium based alloy, to the hub section. The method further comprises partially aging and cooling the hub section prior to welding and aging the airfoil and the weld joint between the airfoil and the hub section subsequent to welding. The post welding aging step is preferably carried out using a novel encapsulated local airfoil heating device having a plurality of heating elements woven into a jacket made from a high temperature cloth material. The method of the present invention may also be used to repair integrally bladed rotors.

Abstract: The present invention relates to a method for fabricating an integrally bladed rotor which comprises providing a hub section, preferably formed from a titanium based alloy, and welding an airfoil, also preferably formed from a titanium based alloy, to the hub section. The method further comprises partially aging and cooling the hub section prior to welding and aging the airfoil and the weld joint between the airfoil and the hub section subsequent to welding. The post welding aging step is preferably carried out using a novel encapsulated local airfoil heating device having a plurality of heating elements woven into a jacket made from a high temperature cloth material. The method of the present invention may also be used to repair integrally bladed rotors.