Abstract: The present invention relates to a composition for treating, improving, or preventing Alzheimer's disease caused by ApoE4 gene mutation, the composition including Banha-Sasim-Tang as an active ingredient. The composition including Banha-Sasim-Tang as an active ingredient of the present invention and a treatment method exhibit excellent effects of reducing amyloid beta proteins and inhibiting deposition thereof, which are specific to Alzheimer's disease caused by ApoE4 gene mutation, thereby having high applicability as a specific composition for preventing, improving, or treating Alzheimer's disease caused by ApoE4 gene mutation.

Abstract: The present invention relates to a composition for inhibiting proliferation of tumor comprising Sanguisorba officinalis extract as effective component. Specifically, as the Sanguisorba officinalis extract binds to PD-L1 present on the surface of cancer cells, the interaction between cancer cells and PD-1 on the surface of T cells is blocked to activate T cells, and thus an inhibitory effect on tumor proliferation is exhibited. Furthermore, when administered to an animal model induced with colorectal cancer, it is possible to obtain a decrease in tumor size and tumor weight and also the enhanced secretion of immune cells (CD8 T cells) and granzyme B in cancer tissues.

Abstract: A composition for inhibiting proliferation of tumor comprising Rubus coreanus extract as effective component. It was found that the Rubus coreanus extract binds to PD-L1 present on the surface of cancer cells, thus blocking the interaction between cancer cells and PD-1 on the surface of T cells to activate T cells and exhibit an inhibitory effect on tumor proliferation, and it was also found that the Rubus coreanus extract shows an excellent anti-tumor immune activity in humanized PD-1 animal model induced with MC38 colorectal cancer expressing human PD-L1 and also a synergistic effect when co-administered with anti-cancer agents.

Abstract: A composition according to an embodiment of the present disclosure can be used for inhibiting tumor proliferation and includes a Salvia plebeia extract as an effective component. It was found that, as a result of binding to PD-L1 present on a surface of cancer cell, Salvia plebeia extract blocks the interaction between cancer cell and PD-1 present on a surface of immune T cell to activate T cells and exhibit an inhibitory effect on tumor proliferation. It was also found that, according to co-culture of cells of colon cancer, breast cancer, or lung cancer with T cells, the group treated with Salvia plebeia extract shows higher effect of causing cancer cell death.

Abstract: Nucleic acid molecules such as shRNA dusters and artificial miRNA dusters are disclosed. Also disclosed are methods of use, compositions, cells, viral particles, and kits relating to the nucleic acid molecules disclosed herein.

Abstract: Nucleic acid molecules such as shRNA clusters and artificial miRNA clusters are disclosed, Also disclosed are methods of use, compositions, cells, viral particles, and kits relating to the nucleic acid molecules disclosed herein. The disclosure provides, at least in part nucleic acid molecules such as shRNA clusters encoding shRNA-like molecules and artificial miRNA clusters encoding modified pri-miRNA-like molecules. The shRNA clusters and artificial miRNA clusters disclosed herein can be used, for example, to produce artificial RNA molecules, e.g., RNAi molecules. Cells, viral particles, compositions (e.g., pharmaceutical compositions), kits, and methods relating to the nucleic acid molecules, e.g., shRNA clusters and artificial miRNA clusters, are also disclosed. The nucleic acid molecules (e.g., shRNA clusters and artificial miRNA clusters), artificial RNA molecules (e.g., RNAi molecules), cells, viral particles, compositions (e.g.

Abstract: Nucleic acid molecules such as shRNA clusters and artificial miRNA clusters are disclosed, Also disclosed are methods of use, compositions, cells, viral particles, and kits relating to the nucleic acid molecules disclosed herein. The disclosure provides, at least in part nucleic acid molecules such as shRNA clusters encoding shRNA-like molecules and artificial miRNA clusters encoding modified pri-miRNA-like molecules. The shRNA clusters and artificial miRNA clusters disclosed herein can be used, for example, to produce artificial RNA molecules, e.g., RNAi molecules. Cells, viral particles, compositions (e.g., pharmaceutical compositions), kits, and methods relating to the nucleic acid molecules, e.g., shRNA clusters and artificial miRNA clusters, are also disclosed. The nucleic acid molecules (e.g., shRNA clusters and artificial miRNA clusters), artificial RNA molecules (e.g., RNAi molecules), cells, viral particles, compositions (e.g.

Abstract: The present invention relates to a composition for treating a bacterial infection comprising an extract from a bark of Alnus pendula, or diarylheptanoid compound as an active ingredient. The extract from a bark of Alnus pendula, diarylheptanoid compound of the present composition has a remarkably excellent anti-bacterial activity against bacteria, specifically Staphylococcus aureus. Therefore, the extract and compound of the present invention may be utilized as an active ingredient of drug, cosmetics, functional food and animal feed for treating bacterial infection, in particular an infection of S. aureus.

Abstract: The present invention relates to a composition for treating a bacterial infection comprising an extract from a bark of Alnus pendula, or diarylheptanoid compound as an active ingredient. The extract from a bark of Alnus pendula, diarylheptanoid compound of the present composition has a remarkably excellent anti-bacterial activity against bacteria, specifically Staphylococcus aureus. Therefore, the extract and compound of the present invention may be utilized as an active ingredient of drug, cosmetics, functional food and animal feed for treating bacterial infection, in particular an infection of S. aureus.