Abstract: The present disclosure relates to a device and method of securing a biological sample collected to permit use of the collected sample with automated specimen analysis devices while maintaining a chain of custody. Further, the present invention relates to an specimen collection device for collecting and tracking a collected biological sample or specimen in a manner suitable for storage and subsequent automated analysis.

Abstract: Apparatus and methods are provided for evidence specimen collection having integral reagent holders to hold reagent vials and having drying agent or desiccant holding areas that permit the renewal of the desiccant and permit the introduction of variously size desiccant qualities to allow modulation of the specimen drying time to achieve early stabilization of specimens while holding the specimen in an isolated drying area during storage and shipment and for simultaneous collection of multiple evidence samples with simultaneous storage, drying, marking, evidence security and shipping provided and with the provision for simultaneous storage, drying, marking, evidence security and shipping provided for a control specimen.

Abstract: A low pressure sample collection apparatus includes a double-ended cap member having similarly sized plug members extending from opposite sides, a vacuum connection nipple on one side and a shaft connection portion one the opposite, a passage extending through the cap from the nipple to the shaft connection portion, a tubular shaft connected to the shaft connection portion and having a sample collection swab member secured to an outer end thereof, and a container member having one end closed and an opposite end open. The cap member is reversibly plugged into the container either to use the container as a handle or to position the swab within the container for protection. A vacuum source may be connected to the assembly to draw air through the swab. The shaft may have a barrel telescoped thereon for separation of the swab from the shaft without contacting the swab.

Abstract: Apparatus and methods are provided for evidence specimen collection having integral reagent holders to hold reagent vials and having drying agent or desiccant holding areas that permit the renewal of the desiccant and permit the introduction of variously size desiccant qualities to allow modulation of the specimen drying time to achieve early stabilization of specimens while holding the specimen in an isolated drying area during storage and shipment and for simultaneous collection of multiple evidence samples with simultaneous storage, drying, marking, evidence security and shipping provided and with the provision for simultaneous storage, drying, marking, evidence security and shipping provided for a control specimen.

Abstract: A holder for a plurality of biological specimen collection devices having collection absorbents extending therefrom is provided, the holder operating to organize and identify the collection devices and operating to position the collection devices for extraction of sample portions from each of the collection absorbents of the multiple collection devices while positioning a sample punch absorbent cleaning strip adjacent the collection absorbent of each device to allow cleaning of the sample punch between each use.

Abstract: A specimen collection apparatus and method is provided that allows for obtaining a specimen of evidence from a crime scene or evidence of any event and the sequential use and transfer and analysis of such evidence in a manner which maintains a demonstrable chain of custody.

Abstract: A device and method of securing the original biological specimen collection absorbent within a holder to permit use of the absorbent within automatic specimen analysis devices and to permit continuance of a chain of custody is provided.

Abstract: A device and method of securing the original biological specimen collection absorbent within a holder to permit use of the absorbent within automatic specimen analysis devices and to permit continuance of a chain of custody is provided.

Abstract: An improved forensic specimen collector includes a collection matrix coated with a dissolvable coating composition. The coating composition covers the irregular surface of the matrix, filling in the holes and openings to prevent passage of collected material specimens into the interior of the matrix. This facilitates retention of the specimens on the outer surface of the matrix and release of all of the specimens for analysis. The specimens are separated from the surface of the collection matrix by contacting the matrix with a liquid solvent selected to dissolve the coating, thereby releasing the specimen into the solvent. The solvent is selected in accordance with its solubility characteristics to form either a suspension of the specimen in the solvent, or to dissolve the specimen into the solvent to form a solution.

Abstract: A containerized low pressure sample collection apparatus includes an elongated tubular shaft with a vacuum connection at one end and a swab at an opposite end. The shaft extends through a housing which can be used as a handle. The housing is adapted to receive a cap at either end, at one end for storage and at the other to cover and protect the swab with a collected sample. A second slide-out of the apparatus embodiment includes a swab structure including a tubular shaft, a swab, and a centering structure which can be slid out of and back into a housing which can also be used as a handle to manipulate the apparatus to collect a sample. Both embodiments can be connected to a vacuum unit to draw air through the swab to collect certain kinds of samples.

Abstract: A holder for a plurality of biological specimen collection devices having collection absorbents extending therefrom is provided, the holder operating to organize and identify the collection devices and operating to position the collection devices for extraction of sample portions from each of the collection absorbents of the multiple collection devices while positioning a sample punch absorbent cleaning strip adjacent the collection absorbent of each device to allow cleaning of the sample punch between each use.

Abstract: A low pressure sample collection apparatus includes a double-ended cap member having similarly sized plug members extending from opposite sides, a vacuum connection nipple on one side and a shaft connection portion one the opposite, a passage extending through the cap from the nipple to the shaft connection portion, a tubular shaft connected to the shaft connection portion and having a sample collection swab member secured to an outer end thereof, and a container member having one end closed and an opposite end open. The cap member is reversibly plugged into the container either to use the container as a handle or to position the swab within the container for protection. A vacuum source may be connected to the assembly to draw air through the swab. The shaft may have a barrel telescoped thereon for separation of the swab from the shaft without contacting the swab.

Abstract: A specimen collection apparatus and method is provided that allows for obtaining a specimen of evidence from a crime scene or evidence of any event and the sequential use and transfer and analysis of such evidence in a manner which maintains a demonstrable chain of custody.

Abstract: An apparatus and method is provided for collecting a DNA sample from the skin and/or from the oral cavity of a subject, the apparatus comprising a handle mounted absorbent layer supported by a resilient layer and bar codes for association of the sample with identification and evidence documents a storage system is provided to allow sample location using a bar code identifier which avoids removal of the device from storage and avoids disturbing the collected sample.

Abstract: A device for collection of DNA-containing materials is provided and a method of preventing DNA specimen contamination is provided which prevents extraneous DNA found in DNA evidence collection kits from interfering with DNA specimen analysis, further a device an method is provided for collecting the DNA-containing material of a subject from the subject's skin.

Abstract: An apparatus and method is provided for collecting a DNA sample from the skin and/or from the oral cavity of a subject, the apparatus comprising a handle mounted absorbent layer supported by a resilient layer and bar codes for association of the sample with identification and evidence documents a storage system is provided to allow sample location using a bar code identifier which avoids removal of the device from storage and avoids disturbing the collected sample.

Abstract: A blood specimen sampling and insulated shipping kit is provided that provides a user with all materials that are needed to initiate blood flow, direct a blood sample into a sample vial, insulate the vial from heat and cold, protect the vial from impact, and ship the blood sample containing vial to a clinical laboratory for testing.

Abstract: An apparatus is provided for oral fluid collection from the mouth the apparatus having a fluid resistant shield adjacent one portion or side of the absorbent to support the absorbent after the absorbent is moist with oral fluid and the shield further operating to block the collection or mucosal transudate from the gum and teeth margin. A method of collection saliva while excluding the collection of mucosal transudate is provided wherein blocking of a portion of an absorbent is performed and the blocked portion of the absorbent is placed adjacent the teeth and gums to exclude any direct collection of mucosal transudate.

Abstract: Methods for detecting the presence or concentration of an analyte in a matrix by exploiting the specificities of the analyte's antibody and enzyme-substrate are disclosed. The analyte is first extracted from the matrix by binding it to its specific antibody which has been attached to a solid surface. The antibody-bound analyte is then separated from the matrix to remove it from any interfering substances. Next, the antibody-bound analyte is reacted with its specific enzyme-substrate to generate a signal proportionate to the amount of analyte bound to the antibody, which in turn is dependent on the quantity of analyte present in the matrix. Applications of the methods of the present invention to detect the presence and concentration of hemoglobin, a transferase, and a serine protease, are specifically disclosed. Further, kits useful for utilizing the methods of the present invention are also disclosed.