Patents by Inventor Janice A. Dominov

Janice A. Dominov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modulating dysferlin expression
    Patent number: 11827886
    Abstract: Aspects of the disclosure relate to methods of altering RNA splicing in a subject. In some embodiments, methods are provided for correcting splicing in a cell that contains a DYSF gene having a mutation that results in defective splicing.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: November 28, 2023
    Assignee: University of Massachusetts
    Inventors: Robert H. Brown, Jr., Janice A. Dominov
  • ANTISENSE OLIGONUCLEOTIDES TO RESTORE DYSFERLIN PROTEIN EXPRESSION IN DYSFERLINOPATHY PATIENT CELLS
    Publication number: 20210246443
    Abstract: The relates, in some aspects, to antisense oligonucleotide compositions and methods for modifying pre-mRNA splicing in a DYSF gene using the same. In some embodiments, the DYSF gene comprises a novel mutation that results in a pseudoexon between exons 50 and 51.
    Type: Application
    Filed: June 7, 2019
    Publication date: August 12, 2021
    Applicant: University of Massachusetts
    Inventors: Robert H. Brown, JR., Janice A. Dominov
  • COMPOSITIONS AND METHODS FOR MODULATING DYSFERLIN EXPRESSION
    Publication number: 20200339999
    Abstract: Aspects of the disclosure relate to methods of altering RNA splicing in a subject. In some embodiments, methods are provided for correcting splicing in a cell that contains a DYSF gene having a mutation that results in defective splicing.
    Type: Application
    Filed: May 12, 2020
    Publication date: October 29, 2020
    Applicant: University of Massachusetts
    Inventors: Robert H. Brown, Janice A. Dominov
  • Compositions and methods for modulating dysferlin expression
    Patent number: 10689653
    Abstract: Aspects of the disclosure relate to methods of altering RNA splicing in a subject. In some embodiments, methods are provided for correcting splicing in a cell that contains a DYSF gene having a mutation that results in defective splicing.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: June 23, 2020
    Assignee: University of Massachusetts
    Inventors: Robert H. Brown, Jr., Janice A. Dominov
  • COMPOSITIONS AND METHODS FOR MODULATING DYSFERLIN EXPRESSION
    Publication number: 20170101645
    Abstract: Aspects of the disclosure relate to methods of altering RNA splicing in a subject. In some embodiments, methods are provided for correcting splicing in a cell that contains a DYSF gene having a mutation that results in defective splicing.
    Type: Application
    Filed: June 3, 2015
    Publication date: April 13, 2017
    Applicant: University of Massachusetts
    Inventors: Robert H. Brown, JR., Janice A. Dominov