Patents by Inventor Janice Au-Young
Janice Au-Young has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6309821Abstract: The present invention provides nucleotide and amino acid sequences for a novel PAC10 human homolog. The present invention also provides for antisense molecules, diagnostic molecules, genetically engineered expression vectors and host cells for the production of purified PAC10 homologs; antibodies, agonists, antagonists and inhibitors of the PAC10 human homolog; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, ntagonists and inhibitors. The invention further provides diagnostic and theapeutic compositions for the detection and treatment of X-linked congenital abnormalities, such as centronuclear myopathy.Type: GrantFiled: May 16, 1996Date of Patent: October 30, 2001Assignee: Incyte Genomics, Inc.Inventors: Janice Au-Young, Richard D. Goold
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Patent number: 6303297Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.Type: GrantFiled: November 13, 1997Date of Patent: October 16, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Steve E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
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Patent number: 6265547Abstract: The invention provides a human cell junction PDZ protein (CJPDZ) and polynucleotides which identify and encode CJPDZ. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CJPDZ.Type: GrantFiled: August 6, 1999Date of Patent: July 24, 2001Assignee: Incyte Genomics, Inc.Inventors: Henry Yue, Janice Au-Young, Chandra Patterson
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Patent number: 6235880Abstract: The present invention provides a human sulfonylurea receptor (SURH) and the polynucleotides which identify and encode SURH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding SURH and methods for producing the protein. The invention also provides pharmaceutical compositions containing SURH, agonists to SURH, or antagonists to SURH, and in the use of such compositions for the prevention or treatment of diseases associated with the expression of SURH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding SURH for the treatment of diseases associated with the expression of SURH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding SURH, or anti-SURH antibodies which specifically bind to SURH.Type: GrantFiled: December 9, 1998Date of Patent: May 22, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Janice Au-Young, Olga Bandman, Roger Coleman
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Patent number: 6232077Abstract: The present invention provides novel human protein kinases (HPK) and polynucleotides which identify and encode HPK. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPK. The invention also provides for pharmaceutical compositions comprising HPK or antagonists of HPK, and antibodies which specifically bind HPK. Additionally, the invention provides antisense molecules to HPK for treatment or prevention of diseases associated with abnormal expression of HPK.Type: GrantFiled: April 3, 2000Date of Patent: May 15, 2001Assignee: Incyte Genomics, Inc.Inventors: Janice Au-Young, Karl J. Guegler, Phillip R. Hawkins
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Patent number: 6190663Abstract: The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.Type: GrantFiled: July 28, 1998Date of Patent: February 20, 2001Assignee: Incyte Genomics, Inc.Inventors: Phillip R. Hawkins, Janice Au-Young, Karl J. Guegler, Craig G. Wilde
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Patent number: 6189013Abstract: Disclosed is a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to association with one or more projects for obtaining full-length biomolecular sequences from shorter sequences. The relational database has sequence records containing information identifying one or more projects to which each of the sequence records belong. Each project groups together one or more biomolecular sequences generated during work to obtain a full-length gene sequence from a shorter sequence. The computer system has a user interface allowing a user to selectively view information regarding one or more projects. The relational database also provides interfaces and methods for accessing and manipulating and analyzing project-based information.Type: GrantFiled: June 24, 1999Date of Patent: February 13, 2001Assignee: Incyte Genomics, Inc.Inventors: Timothy J. Maslyn, Janice Au-Young, Jennifer L. Hillman, Harold Hibbert, Ingrid E. Akerblom, Rachel J. Cheng, Yuanhua T. Tang
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Patent number: 6171815Abstract: The present invention provides a human sulfonylurea receptor (SURH) and the polynucleotides which identify and encode SURH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding SURH and methods for producing the protein. The invention also provides pharmaceutical compositions containing SURH, agonists to SURH, or antagonists to SURH, and in the use of such compositions for the prevention or treatment of diseases associated with the expression of SURH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding SURH for the treatment of diseases associated with the expression of SURH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding SURH, or anti-SURH antibodies which specifically bind to SURH.Type: GrantFiled: October 2, 1996Date of Patent: January 9, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Janice Au-Young, Olga Bandman, Roger Coleman
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Patent number: 6172199Abstract: The present invention provides a polynucleotide (ubcp) which identifies and encodes a novel ubiquitin-conjugating enzyme (UBCP). The invention provides for genetically engineered expression vectors and host cells comprising the nuclei acid sequence encoding UBCP. The invention also provides for the use of substantially purified UBCP and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of UBCP. Additionally, the invention provides for the use of antisense molecules to ubcp in pharmaceutical compositions for treatment of diseases associated with the expression of UBCP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ubcp or anti-UBCP antibodies which specifically bind to UBCP.Type: GrantFiled: May 25, 1999Date of Patent: January 9, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Janice Au-Young, Surya K. Goli, Jennifer L. Hillman
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Patent number: 6143870Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel thrombin receptor homolog (TRH) expressed in human liver. The present invention also provides for antisense molecules to the nucleotide sequences which encode TRH, diagnostic tests based on TRH encoding nucleic acid molecules, expression vectors for the production of purified TRH, antibodies capable of binding specifically to TRH, hybridization probes or oligonucleotides for the detection of TRH-encoding nucleotide sequences, genetically engineered host cells for the expression of TRH, and antagonists, antibodies and inhibitors with specific binding activity for the polypeptide TRH.Type: GrantFiled: December 21, 1998Date of Patent: November 7, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Roger Coleman, Janice Au-Young, Olga Bandman, Jeffrey J. Seilhamer
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Patent number: 6135941Abstract: The invention provides human immune system associated proteins (HISAP) and polynucleotides which identify and encode HISAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HISAP.Type: GrantFiled: March 27, 1998Date of Patent: October 24, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Jennifer L. Hillman, Preeti Lal, Y. Tom Tang, Henry Yue, Janice Au-Young, Neil C. Corley, Karl J. Guegler, Mariah R. Baughn
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Patent number: 6132973Abstract: The invention provides human regulatory molecules and polynucleotides (collectively designated HRM) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing, preventing, and treating disorders associated with expression of human regulatory molecules.Type: GrantFiled: January 20, 1999Date of Patent: October 17, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Preeti Lal, Jennifer L. Hillman, Olga Bandman, Purvi Shah, Janice Au-Young, Henry Yue, Karl J. Guegler, Neil C. Corley
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Patent number: 6130077Abstract: The invention provides a human cytochrome P450 (HUCYP) and polynucleotides which identify and encode HUCYP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HUCYP.Type: GrantFiled: October 1, 1998Date of Patent: October 10, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Henry Yue, Karl J. Guegler, Neil C. Corley, Janice Au-Young
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Patent number: 6124116Abstract: The present invention provides four human Rab and Rab-associated proteins (designated collectively as HRAB) and polynucleotides which identify and encode HRAB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HRAB and a method for producing HRAB. The invention also provides for use of HRAB and agonists, antibodies, or antagonists specifically binding HRAB, in the prevention and treatment of diseases associated with expression of HRAB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HRAB for the treatment of diseases associated with the expression of HRAB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HRAB.Type: GrantFiled: October 29, 1996Date of Patent: September 26, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Olga Bandman, Janice Au-Young
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Patent number: 6113904Abstract: The present invention provides polynucleotides which identify and encode a novel human glycoprotein (SC2H). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding SC2H. The invention also provides for the use of substantially purified SC2H and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of SC2H. Additionally, the invention provides for the use of antisense molecules to SC2H in the treatment of diseases associated with the expression of SC2H. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding SC2H and antibodies which specifically bind to the protein.Type: GrantFiled: April 20, 1998Date of Patent: September 5, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Olga Bandman, Janice Au-Young, Phillip R. Hawkins, Jennifer L. Hillman
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Patent number: 6090377Abstract: The present invention provides novel monocyte activating cytokine (MAC) and a polynucleotide encoding MAC. The invention also provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MAC. The invention also provides for the production and use of substantially purified MAC in pharmaceutical compositions for the treatment of cancer and disease of the immune system. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding MAC and antibodies which specifically bind to MAC.Type: GrantFiled: July 28, 1998Date of Patent: July 18, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Olga Bandman, Roger Coleman, Janice Au-Young, Lynn E. Murry
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Patent number: 6080548Abstract: The invention provides human cyclic nucleotide phosphodiesterases (PDE8) and polynucleotides which identify and encode PDE8. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PDE8.Type: GrantFiled: February 23, 1999Date of Patent: June 27, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Janice Au-Young, Benjamin G. Cocks, Roger Coleman, Jeffrey J. Seilhamer, Douglas A. Fisher
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Patent number: 6080848Abstract: The invention provides a human human brain-associated protein (HBAP-1) and polynucleotides which identify and encode HBAP-1. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HBAP-1.Type: GrantFiled: May 1, 1998Date of Patent: June 27, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Sven Henrichwark, Janice Au-Young, Karl J. Guegler, Neil C. Corley, Mariah R. Baughn
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Patent number: 6080841Abstract: The present invention provides a polynucleotide which identifies and encodes a novel human induced tumor protein (HITP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HITP. The invention also provides for the production and use of substantially purified HITP in pharmaceutical compositions to force differentiation and to stop cell division in cancerous cells. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HITP and the anti-HITP antibodies which specifically bind to HITP.Type: GrantFiled: April 9, 1998Date of Patent: June 27, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Janice Au-Young, Phillip R. Hawkins
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Patent number: 6077693Abstract: The invention provides a human promonocyte associated protein (PRMNC) and polynucleotides which identify and encode PRMNC. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of PRMNC.Type: GrantFiled: May 14, 1998Date of Patent: June 20, 2000Assignee: Incyte Pharmaceuticals, Inc.Inventors: Y. Tom Tang, Brian McKelligon, Janice Au-Young, Neil C. Corley, Karl J. Guegler, Chandra Patterson