Patents by Inventor Janice E. Clements

Janice E. Clements has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Borna disease virus-specific DNA and proteins
    Patent number: 6060236
    Abstract: Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.
    Type: Grant
    Filed: December 29, 1998
    Date of Patent: May 9, 2000
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Janice E. Clements, Opendra Narayan, Susan Vandewoude, Juergen A. Richt
  • Recombinationally targeted cloning in yeast artificial chromosomes
    Patent number: 5776745
    Abstract: Homologous recombination techniques are used to produce yeast artificial chromosomes (YAC) containing foreign target DNA by utilizing at least three DNA segments which yield the vector. Preferred embodiments allow the production of viral DNA which is infectious.
    Type: Grant
    Filed: October 11, 1995
    Date of Patent: July 7, 1998
    Assignee: The Johns Hopkins University
    Inventors: Gary Wayne Ketner, Philip Andrew Hieter, Janice E. Clements
  • Borna disease virus-specific protein and kits
    Patent number: 5654401
    Abstract: Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: August 5, 1997
    Assignee: The Johns Hopkins University
    Inventors: Janice E. Clements, Opendra Narayan, Susan Vandewoude, Juergen A. Richt