Patents by Inventor Janice E. Rugaber

Janice E. Rugaber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for producing recombinant histidine-tagged inosine nonophosphate dehydrogenase polypeptides
    Patent number: 7531336
    Abstract: The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of the histidine-tagged, modified IMPDH polypeptide is maintained relative to the wild-type IMPDH polypeptide. The invention also relates to a method, nucleic acid molecules, vectors, and host cells for producing such a histidine-tagged, modified IMPDH polypeptide, and to kits comprising the histidine-tagged, modified IMPDH polypeptide.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: May 12, 2009
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Allan R. Dorn, Janice E. Rugaber
  • Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides
    Patent number: 7276362
    Abstract: The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of the histidine-tagged, modified IMPDH polypeptide is maintained relative to the wild-type IMPDH polypeptide. The invention also relates to a method, nucleic acid molecules, vectors, and host cells for producing such a histidine-tagged, modified IMPDH polypeptide, and to kits comprising the histidine-tagged, modified IMPDH polypeptide.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: October 2, 2007
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Allan R. Dorn, Janice E. Rugaber