Patents by Inventor Janice L. Pfeil

Janice L. Pfeil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-Epi 3-exomethylenecephams
    Patent number: 4431803
    Abstract: 7-Epi-3-exomethylenecephams are useful intermediates for synthesis of antibiotics.
    Type: Grant
    Filed: December 21, 1981
    Date of Patent: February 14, 1984
    Assignee: Eli Lilly and Company
    Inventors: Stjepan Kukolja, Janice L. Pfeil
  • Unsymmetrical azetidinone aldehyde disulfides and process
    Patent number: 4407750
    Abstract: Aryl 4R[1-(2-N-3-methyl-4-al-Z-but-2-ene-oate)-2-oxo-3s-acylamino azetidinone]disulfides are prepared by reacting the corresponding 7.alpha.-acylamino-2.alpha.-alkoxy-3-methyl-3-cephem-4-carboxylates first with either phenylsulfenyl chloride or a monosubstituted-phenylsulfenyl chloride where the substituent is either chloro, methoxy, methyl or acetoxy. The disulfide compounds produced in this invention are intermediates in the synthesis of the 7.beta.-acylamino-7.alpha.-alkoxy-3-methyl 1-oxa .beta.-lactam acids, a class of antibiotic compounds.
    Type: Grant
    Filed: August 7, 1981
    Date of Patent: October 4, 1983
    Assignee: Eli Lilly and Company
    Inventors: Stjepan Kukolja, Janice L. Pfeil
  • Symmetrical azetidinone aldehyde disulfides and process
    Patent number: 4394313
    Abstract: 4R, 4'R bis [1-(2-N-3-methyl-4-al-Z-but-2-ene-oate)-2-oxo-3S-acylamino azetidine]disulfide compounds are prepared by reacting the corresponding 7.alpha.-acylamino-2.alpha.-alkoxy-3-methyl-3-cephem-4-carboxylates first with an N-chloro halogenating agent, e.g., N-chlorosuccinimide, then with an aqueous suspension of mercury dichloride and cadmium carbonate. The disulfide compounds produced in this invention are intermediates in the synthesis of the biologically active 7.beta.-acyl-amino-7.alpha.-alkoxy-3-methyl 1-oxa .beta.-lactam antibiotic compounds.
    Type: Grant
    Filed: May 18, 1981
    Date of Patent: July 19, 1983
    Assignee: Eli Lilly and Company
    Inventors: Stjepan Kukolja, Janice L. Pfeil
  • Process for cyclization
    Patent number: 4335240
    Abstract: Azetidinone alcohol disulfides are synthesized by reduction of the corresponding aldehydes. The azetidinone alcohol disulfides are the substrates for a process which cyclizes these compounds to 1-oxa .beta.-lactam compounds, employing a cyclizing reagent chosen from the class consisting of divalent mercury salts or tri-valent phosphine compounds. The 1-oxa .beta.-lactam compounds produced by this process are intermediates in the synthesis of 1-oxa .beta.-lactam antibiotics.
    Type: Grant
    Filed: May 18, 1981
    Date of Patent: June 15, 1982
    Assignee: Eli Lilly and Company
    Inventors: Stjepan Kukolja, Janice L. Pfeil
  • Unsymmetrical azetidinone aldehyde disulfides and process
    Patent number: 4302391
    Abstract: Aryl 4R[1-(2-N-3-methyl-4-al-Z-but-2-ene-oate)-2-oxo-3S-acylamino azetidinone]disulfides are prepared by reacting the corresponding 7.alpha.-acylamino-2.alpha.-alkoxy-3-methyl-3-cephem-4-carboxylates first with either phenylsulfenyl chloride or a monosubstituted-phenylsulfenyl chloride where the substituent is either chloro, methoxy, methyl or acetoxy. The disulfide compounds produced in this invention are intermediates in the synthesis of the 7.beta.-acylamino-7.alpha.-alkoxy-3-methyl 1-oxa .beta.-lactam acids, a class of antibiotic compounds.
    Type: Grant
    Filed: April 7, 1980
    Date of Patent: November 24, 1981
    Assignee: Eli Lilly and Company
    Inventors: Stjepan Kukolja, Janice L. Pfeil
  • Azetidinone alcohol disulfides and process for cyclization
    Patent number: 4293493
    Abstract: Azetidinone alcohol disulfides are synthesized by reduction of the corresponding aldehydes. The azetidinone alcohol disulfides are the substrates for a process which cyclizes these compounds to 1-oxa .beta.-lactam compounds, employing a cyclizing reagent chosen from the class consisting of divalent mercury salts or trivalent phosphine compounds. The 1-oxa .beta.-lactam compounds produced by this process are intermediates in the synthesis of 1-oxa .beta.-lactam antibiotics.
    Type: Grant
    Filed: April 7, 1980
    Date of Patent: October 6, 1981
    Assignee: Eli Lilly and Company
    Inventors: Stjepan Kukolja, Janice L. Pfeil
  • Symmetrical azetidinone aldehyde disulfides and process
    Patent number: 4293495
    Abstract: 4R,4'R bis[1-(2-N-3-methyl-4-al-Z-but-2-ene-oate)-2-oxo-3S-acylamino azetidine]disulfide compounds are prepared by reacting the corresponding 7.alpha.-acylamino-2.alpha.-alkoxy-3-methyl-3-cephem-4-carboxylates first with an N-chloro halogenating agent, e.g., N-chlorosuccinimide, then with an aqueous suspension of mercury dichloride and cadmium carbonate. The disulfide compounds produced in this invention are intermediates in the synthesis of the biologically active 7.beta.-acylamino-7.alpha.-alkoxy-3-methyl 1-oxa .beta.-lactam antibiotic compounds.
    Type: Grant
    Filed: April 7, 1980
    Date of Patent: October 6, 1981
    Assignee: Eli Lilly and Company
    Inventors: Stjepan Kukolja, Janice L. Pfeil