Patents by Inventor Janice Lau
Janice Lau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230143841Abstract: Provided are non-natural or variant ?-ketoacyl-acyl carrier protein (ACP) synthase (KAS) IVa enzymes (KASIVa), polynucleotides encoding such variant KASIVa, host cells expressing such variant KASIVa, oils and oil products produced by such cells, and methods of making and using such variant KASIVa.Type: ApplicationFiled: January 15, 2021Publication date: May 11, 2023Inventors: Joshua FERREIRA, Janice Lau WEE, Nien-Hsi KO
-
Patent number: 11618890Abstract: Provided are non-natural or variant beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS) II enzymes (KASII), polynucleotides encoding such variant KASII, host cells expressing such variant KASII, oils and oil products produced by such cells, and methods of making and using such variant KASII.Type: GrantFiled: August 21, 2019Date of Patent: April 4, 2023Assignee: Corbion Biotech, Inc.Inventors: Nien-Hsi Ko, Joshua Ferreira, Janice Lau Wee, William E. Maffe, Douglas A. Hattendorf
-
Publication number: 20230037413Abstract: The present disclosure provides sucrose invertase variants having an enhanced ability to hydrolyze sucrose into glucose and fructose and related methods and compositions.Type: ApplicationFiled: November 19, 2020Publication date: February 9, 2023Applicant: Corbion Biotech, Inc.Inventors: Nien-Hsi KO, Janice Lau WEE, Douglas A. HATTENDORF
-
Patent number: 11352602Abstract: The present invention provides methods for making microalgal strains with improved properties relative to the strains from which they are derived. In illustrative embodiments, the methods are performed to produce microalgal strains adapted for use in the industrial production of microalgae-derived biomass products, including but not limited to triglycerides and fatty acids. Also provided are microalgal strains, which can be obtained using the methods described herein, as wells microalgal-derived biomass products, which can be produced from such microalgal strains.Type: GrantFiled: March 30, 2016Date of Patent: June 7, 2022Assignee: Corbion Biotech, Inc.Inventors: Janice Lau Wee, Dawei Yuan, Wenhua Lu, Rika Regentin, Jeffrey Villari
-
Publication number: 20210246434Abstract: Provided are non-natural or variant beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS) II enzymes (KASII), polynucleotides encoding such variant KASII, host cells expressing such variant KASII, oils and oil products produced by such cells, and methods of making and using such variant KASII.Type: ApplicationFiled: August 21, 2019Publication date: August 12, 2021Inventors: Nien-Hsi KO, Joshua FERREIRA, Janice Lau WEE, William E. MAFFE, Douglas A. HATTENDORF
-
Publication number: 20180163170Abstract: The present invention provides methods for making microalgal strains with improved properties relative to the strains from which they are derived. In illustrative embodiments, the methods are performed to produce microalgal strains adapted for use in the industrial production of microalgae-derived biomass products, including but not limited to triglycerides and fatty acids. Also provided are microalgal strains, which can be obtained using the methods described herein, as wells microalgal-derived biomass products, which can be produced from such microalgal strains.Type: ApplicationFiled: March 30, 2016Publication date: June 14, 2018Applicant: TERRAVIA HOLDINGS, INC.Inventors: Janice Lau WEE, Dawei YUAN, Wenhua LU, Rika REGENTIN, Jeffrey VILLARI
-
Patent number: 7855192Abstract: Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynthesis of the natural starter unit 3-amino-5-hydroxybenzoic acid has been deleted.Type: GrantFiled: January 23, 2008Date of Patent: December 21, 2010Assignee: Kosan Biosciences, Inc.Inventors: Gary W. Ashley, Hugo Menzella, Janice Lau Wee, John R. Carney
-
Publication number: 20100004234Abstract: Resorcylic acid lactones having a C5-C6 cis double bond and a ketone at C7 and other compounds capable of Michael adduct formation are potent and stable inhibitors of a subset of protein kinases having a specific cysteine residue in the ATP binding site.Type: ApplicationFiled: August 6, 2009Publication date: January 7, 2010Inventors: Daniel V. Santi, Ralph C. Reid, C. Richard Hutchinson, Kurt F. Sundermann, Janice Lau
-
Publication number: 20080188450Abstract: Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynthesis of the natural starter unit 3-amino-5-hydroxybenzoic acid has been deleted.Type: ApplicationFiled: January 23, 2008Publication date: August 7, 2008Inventors: Gary W. Ashley, Hugo Menzella, Janice Lau Wee, John R. Carney
-
Publication number: 20070092954Abstract: Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.Type: ApplicationFiled: August 8, 2005Publication date: April 26, 2007Inventors: Robert Arslanian, Gary Ashley, Scott Frykman, Bryan Julien, Leonard Katz, Chaitan Khosla, Janice Lau, Peter Licari, Rika Regentin, Daniel Santi, Li Tang
-
Publication number: 20060079494Abstract: Resorcylic acid lactones having a C5-C6 cis double bond and a ketone at C7 and other compounds capable of Michael adduct formation are potent and stable inhibitors of a subset of protein kinases having a specific cysteine residue in the ATP binding site.Type: ApplicationFiled: September 26, 2005Publication date: April 13, 2006Inventors: Daniel Santi, Ralph Reid, C. Hutchinson, Kurt Sundermann, Janice Lau
-
Publication number: 20040018597Abstract: The stereochemical centers of a polyketide can be changed by replacement of ketosynthase domains in the polyketide synthase (PKS) enzyme that produces the polyketide. The specificity of the AT domains of a PKS is determined by a hypervariable region that can be replaced or altered to change the specificity of the AT domain from a naturally occurring extender unit to another naturally or non-naturally occurring extender unit. Non-naturally occurring extender units, including methylmalonyl N-acetyl cysteamine thioester can be incorporated into polyketides in recombinant host cells or in cell-free systems to make polyketides.Type: ApplicationFiled: March 25, 2003Publication date: January 29, 2004Inventors: Chaitan Khosla, Janice Lau, Nicola L. Pohl
-
Patent number: 6551802Abstract: The stereochemical centers of a polyketide can be changed by replacement of ketosynthase domains in the polyketide synthase (PKS) enzyme that produces the polyketide. The specificity of the AT domains of a PKS is determined by a hypervariable region that can be replaced or altered to change the specificity of the AT domain from a naturally occurring extender unit to another naturally or non-naturally occurring extender unit. Non-naturally occurring extender units, including methylmalonyl N-acetyl cysteamine thioester can be incorporated into polyketides in recombinant host cells or in cell-free systems to make polyketides.Type: GrantFiled: December 12, 2000Date of Patent: April 22, 2003Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Chaitan Khosla, Janice Lau, Nicola L. Pohl
-
Publication number: 20030073205Abstract: Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.Type: ApplicationFiled: September 19, 2001Publication date: April 17, 2003Inventors: Robert L. Arslanian, Gary Ashley, Scott Frykman, Bryan Julien, Leonard Katz, Chaitan Khosla, Janice Lau, Peter J. Licari, Rika Regentin, Daniel Santi, Li Tang
-
Publication number: 20010051356Abstract: The stereochemical centers of a polyketide can be changed by replacement of ketosynthase domains in the polyketide synthase (PKS) enzyme that produces the polyketide. The specificity of the AT domains of a PKS is determined by a hypervariable region that can be replaced or altered to change the specificity of the AT domain from a naturally occurring extender unit to another naturally or non-naturally occurring extender unit. Non-naturally occurring extender units, including methylmalonyl N-acetyl cysteamine thioester can be incorporated into polyketides in recombinant host cells or in cell-free systems to make polyketides.Type: ApplicationFiled: December 12, 2000Publication date: December 13, 2001Inventors: Chaitan Khosla, Janice Lau, Nicola L. Pohl
-
Patent number: 6221641Abstract: The stereochemical centers of a polyketide can be changed by replacement of ketosynthase domains in the polyketide synthase (PKS) enzyme that produces the polyketide. The specificity of the AT domains of a PKS is determined by a hypervariable region that can be replaced or altered to change the specificity of the AT domain from a naturally occurring extender unit to another naturally or non-naturally occurring extender unit. Non-naturally occurring extender units, including methylmalonyl N-acetyl cysteamine thioester can be incorporated into polyketides in recombinant host cells or in cell-free systems to make polyketides.Type: GrantFiled: July 2, 1999Date of Patent: April 24, 2001Assignee: Leland Stanford Junior UniversityInventors: Chaitan Khosla, Janice Lau, Nicola L. Pohl