Abstract: Systems and methods for generation and use of vendor management platform architectures are disclosed. A compliance component may be utilized to receive user input data indicating supply contracts between a client and a vendor. The user input data may be utilized to determine insurable obligations associated with the supply contract and provide indications as to whether or not the vendor is compliant with the insurable obligation required by the supply contract. An exposure assessment component may be utilized to determine an exposure score associated with a client account and/or a vendor account based on various compliance factors, spending amounts, and/or properties associated with at least one of goods and/or services that a vendor will supply to a client.

Abstract: Systems and methods for generation and use of intellectual-property (IP) landscaping platform architectures are disclosed. A landscaping component may be utilized to produce refined clusters of IP assets using user seeded searches in varying areas of interest, such as, for example, target technical fields, targeted publications, targeted products, and/or competitor entity portfolios. The landscaping component may be further utilized to produce an interactive graphical element including a spatial representation of the clusters of IP assets. The interactive graphical element may include various functionalities and/or information associated with the clusters of IP assets.

Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Abstract: The present invention provides a compound of formula I: wherein R1, X1, X2, R2, R3, R4, R5, n, and m are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Abstract: The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (HA). The biomaterial compositions utilize small HA binding peptides that is tethered to synthetic biocompatible polymers. When tethered to the polymers, the peptide region allows the polymers to bind to HA. The biocompatible polymers are modified to contain a crosslinking group so that the HA can be incorporated into a scaffold and retained in place. The novel biomaterial 1 compositions can be made into hydrogel compositions and used in a variety of tissue applications, using mild crosslinking conditions and they also have the ability to be degraded with hyaluronidase if needed. Furthermore, the novel biomaterial compositions will enable enhanced interaction between the scaffold and encapsulated cells for a wide variety of tissue engineering applications. Methods of making hydrogel compositions and their use are also provided.

Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Abstract: A holder for securing eyeglasses, sunglasses or other personal items that may be securely incorporated into an article of clothing or accessory at the time of manufacture. The holder includes a base member that can be inserted into or attached to the article of clothing or accessory. A hanger is connected to the base member and includes a loop connected to a support base. One or more openings can be provided on the base member. The support base and base member can be integrally formed. The support base can be formed from part of the article of clothing or accessory. The holder allows a wearer to insert a piece of a pair of eyeglasses, or a part of another personal item, through the loop and allows the item to assume a secure and relatively flat position. The holder may also include an RFID tag and/or a covered loop.

Abstract: The present invention provides a compound of formula I: wherein R1, X1, X2, R2, R3, R4, R5, n, and m are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.

Abstract: A holder for securing eyeglasses, sunglasses or other personal items that may be securely incorporated into an article of clothing or accessory at the time of manufacture. The holder includes a base member that can be inserted into or attached to the article of clothing or accessory. A hanger is connected to the base member and includes a loop connected to a support base. One or more openings can be provided on the base member. The support base and base member can be integrally formed. The support base can be formed from part of the article of clothing or accessory. The holder allows a wearer to insert a piece of a pair of eyeglasses, or a part of another personal item, through the loop and allows the item to assume a secure and relatively flat position. The holder may also include an RFID tag and/or a covered loop.

Abstract: The invention provides modified collagen and related therapeutic and diagnostic methods.

Abstract: Visible light-activated polymer cosmetic filler preparations useful in a variety of applications are provided. In some embodiments, the photo-activated polymer composition comprises a conventional polymeric material, such as HA, together with a modified, crosslinkable polymer, such as PEG or PEODA, to permit the formation of crosslinks within the polymer matrix in situ on exposure to a visible light source, such as an IPL device. The preparations provide for a more stabilized composition that is contourable during gelation.

Abstract: A holder for securing glasses or other personal item that is securely incorporated into an article of clothing or accessory at the time of manufacture. The holder includes a base member inserted into or attached to the article or accessory or to a trim which is itself attached to an article or accessory. A hanger is connected to the base member and includes a loop connected to a support base. One or more openings can be provided on the base member. The support base and base member can be integrally formed. The support base can be formed from part of the article or accessory or trim. The holder allows a wearer to insert a piece of a pair of glasses, or a part of another item, through the loop and allows the item to assume a secure and relatively flat position. It may include an RFID tag and/or a cover.

Abstract: The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (HA). The biomaterial compositions utilize small HA binding peptides that is tethered to synthetic biocompatible polymers. When tethered to the polymers, the peptide region allows the polymers to bind to HA. The biocompatible polymers are modified to contain a crosslinking group so that the HA can be incorporated into a scaffold and retained in place. The novel biomaterial 1 compositions can be made into hydrogel compositions and used in a variety of tissue applications, using mild crosslinking conditions and they also have the ability to be degraded with hyaluronidase if needed. Furthermore, the novel biomaterial compositions will enable enhanced interaction between the scaffold and encapsulated cells for a wide variety of tissue engineering applications. Methods of making hydrogel compositions and their use are also provided.

Abstract: The invention provides modified collagen and related therapeutic and diagnostic methods.

Abstract: A holder for securing eyeglasses, sunglasses or other personal items that may be securely incorporated into an article of clothing or accessory at the time of manufacture. The holder includes a base member that can be inserted into or attached to the article of clothing or accessory. A hanger is connected to the base member and includes a loop connected to a support base. One or more openings can be provided on the base member. The support base and base member can be integrally formed. The support base can be formed from part of the article of clothing or accessory. The holder allows a wearer to insert a piece of a pair of eyeglasses, or a part of another personal item, through the loop and allows the item to assume a secure and relatively flat position. The holder may also include an RFID tag and/or a covered loop.