Patents by Inventor Janice R. Sufrin

Janice R. Sufrin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substrate for detection of mammalian 5-C-DNA methyltransferase
    Patent number: 5652105
    Abstract: A substrate selective for detection of mammalian 5-C-DNA methyltransferase in the presence of bacterial 5-C-DNA methyltransferase, said substrate comprising oligomeric DNA which contains at least one 5-methylcytosine residue, and at least one cytosine or 5-fluorocytosine residue, each of which are followed in linkage to a guanine residue. The invention also includes a method for measuring the presence of mammalian 5-C-DNA methyltransferase which comprises contacting a sample containing 5-C-DNA methyl transferase with the substrate and also includes a method for inhibiting mammalian 5-C-DNA methyltransferase which comprises contacting a sample containing 5-C-DNA methyl transferase with the substrate.
    Type: Grant
    Filed: July 28, 1995
    Date of Patent: July 29, 1997
    Assignee: Health Research, Inc.
    Inventors: Janice R. Sufrin, Judith K. Christman, Canio J. Marasco, Jr., Gholamreza Sheikhnejad
  • 5'-deoxy-5'-(substituted)alkylthioribose compounds and their pharmaceutical compositions
    Patent number: 5563125
    Abstract: The compounds 5'-deoxy-5'-(hydroxyethylthio)adenosine (HETA); 5'-deoxy-5'-(monofluoroethylthio)adenosine (MFETA); 5'-deoxy-5'-(chloroethylthio)adenosine (CETA); 5'-deoxy-5'-(bromoethylthio)adenosine (BETA); 5-deoxy-5-(monofluoroethylthio)ribose (MFETR); 5-deoxy-5-(chloroethylthio)ribose (CETR); 5-deoxy-5-(bromoethylthio)ribose (BETR) and 5-deoxy-5-(hydroxyethylthio)ribose (HETR), are described as well as their uses in treating infections caused by 5'-deoxy-5'-methylthioadenosine (MTA) phosphorylase-containing pathogenic microorganisms; in treating infections caused by 5-deoxy-5-methylthioribose (MTR) kinase-containing pathogenic microorganism; and for treating neoplastic diseases.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: October 8, 1996
    Assignees: Health Research, Inc., Pace University
    Inventors: Janice R. Sufrin, Cyrus J. Bacchi, Carl W. Porter, Henry Nathan, deceased, Arthur J. Spiess, Nigel Yarlett
  • Adenosine compounds for the treatment of diseases caused by parasitic protozoa
    Patent number: 5180714
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: January 19, 1993
    Assignee: Health Research, Inc.
    Inventors: Janice R. Sufrin, Cyrus J. Bacchi, Carl W. Porter, Henry Nathan, Arthur J. Spiess, Nigel Yarlett