Abstract: The disclosure relates to methods of treating multiple sclerosis and maintaining or maximizing vaccine effectiveness. In certain aspects, the methods comprise administrating ponesimod, administering a vaccine, and interrupting the administration of the ponesimod.

Abstract: A mobile communications system includes at least one subscriber; a home exchange for the at least one subscriber; at least two exchanges, which may include the home exchange, that may be accessed by the at least one subscriber; and means for ensuring that the at least one subscriber has registered as being located within only one of the at least two exchanges. A method according to the teachings of the present invention includes the steps of cancelling all but the last registration when more than one registration is effected and correctly reestablishing mobile station registration and location data by sending an audit message from the exchanges in which a registration was cancelled to a mobile when the registration was cancelled within a predetermined period of time after being established.