Patents by Inventor Janine Borgaro

Janine Borgaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for identifying hydroxymethylcytosine in a DNA
    Patent number: 10597647
    Abstract: Provided herein in some embodiments is a non-naturally occurring variant of a wild type restriction enzyme defined by SEQ ID NO: 20, wherein the variant has at least a 2 fold increase in cleavage at 5-? glucosylhydroxymethylcytosine (5?ghmC) compared with methylcytosine relative to the wild type enzyme. Methods for examining hydroxymethylation of a DNA sample using the variant enzyme are also provided.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: March 24, 2020
    Assignee: New England Biolabs, Inc.
    Inventors: Zhenyu Zhu, Janine Borgaro, Aine Quimby, Shengxi Guan, Zhiyi Sun
  • Mapping cytosine modifications
    Patent number: 10081827
    Abstract: Methods, compositions and kits for selectively altering and detecting modified cytosine residues are provided.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: September 25, 2018
    Assignee: New England Biolabs, Inc.
    Inventors: Shengxi Guan, Nan Dai, Zhenyu Zhu, Ivan R. Correa, Jr., Aine Quimby, Janine Borgaro
  • Mapping Cytosine Modifications
    Publication number: 20160138079
    Abstract: Methods, compositions and kits for selectively altering and detecting modified cytosine residues are provided.
    Type: Application
    Filed: January 12, 2016
    Publication date: May 19, 2016
    Applicant: New England Biolabs, Inc.
    Inventors: Shengxi Guan, Nan Dai, Zhenyu Zhu, Ivan R. Correa, JR., Aine Quimby, Janine Borgaro
  • Mapping cytosine modifications
    Patent number: 9267117
    Abstract: Methods, compositions and kits for selectively altering and detecting modified cytosine residues are provided.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 23, 2016
    Assignee: New England Biolabs, Inc.
    Inventors: Shengxi Guan, Nan Dai, Zhenyu Zhu, Ivan R. Correa, Jr., Aine Quimby, Janine Borgaro
  • Compositions and Methods for Identifying Hydroxymethylcytosine in a DNA
    Publication number: 20150004596
    Abstract: Provided herein in some embodiments is a non-naturally occurring variant of a wild type restriction enzyme defined by SEQ ID NO: 20, wherein the variant has at least a 2 fold increase in cleavage at 5-? glucosylhydroxymethylcytosine (5?ghmC) compared with methylcytosine relative to the wild type enzyme. Methods for examining hydroxymethylation of a DNA sample using the variant enzyme are also provided.
    Type: Application
    Filed: June 27, 2014
    Publication date: January 1, 2015
    Inventors: Zhenyu Zhu, Janine Borgaro, Aine Quimby, Shengxi Guan, Zhiyi Sun
  • Mapping Cytosine Modifications
    Publication number: 20140127678
    Abstract: Methods, compositions and kits for selectively altering and detecting modified cytosine residues are provided.
    Type: Application
    Filed: March 14, 2013
    Publication date: May 8, 2014
    Inventors: Shengxi Guan, Nan Dai, Zhenyu Zhu, Ivan R. Correa, Jr., Aine Quimby, Janine Borgaro