Abstract: The present innovation relates to the field of biomaterials, drug delivery systems, load-bearing materials for bone regeneration and dental restauration. The method for fabrication of amorphous calcium phosphate ceramic-based drug delivery system is proposed. According to the method, mixture of amorphous calcium phosphate and at least one drug is sintered at pressure that exceeds 500 MPa, preferably in the range of 600 to 1500 MPa, at temperature from 15 to 35° C. The selected pressure range allows to obtain on amorphous calcium phosphate ceramic-based long-term drug delivery system with excellent mechanical properties.

Abstract: The method of making an implant consists on coating of a supporting structure (1) with synthetic hydroxyapatite by immersing the supporting structure (1) in a suspension (3) and triggering of a cavitation in a portion of the suspension (3) being in contact with the supporting structure (1). The suspension (3) is formed by a liquid external phase, advantageously water, and internal phase, i.e. particles of synthetic hydroxyapatite having an average particle size not exceeding 100 nm and containing structural water in an amount from 2 to 6% by weight. The implant is coated with the above described hydroxyapatite subjected to cavitation and a thickness of 50 nm to 1000 nm, advantageously 50 nm to 300 nm.

Abstract: The method of making an implant consists on coating of a supporting structure (1) with synthetic hydroxyapatite by immersing the supporting structure (1) in a suspension (3) and triggering of a cavitation in a portion of the suspension (3) being in contact with the supporting structure (1). The suspension (3) is formed by a liquid external phase, advantageously water, and internal phase, i.e. particles of synthetic hydroxyapatite having an average particle size not exceeding 100 nm and containing structural water in an amount from 2 to 6% by weight. The implant is coated with the above described hydroxyapatite subjected to cavitation and a thickness of 50 nm to 1000 nm, advantageously 50 nm to 300 nm.