Patents by Inventor Janis Upeslacis

Janis Upeslacis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing targeted forms of methyltrithio antitumor agents
    Patent number: 5770701
    Abstract: This disclosure describes a method for constructing targeting agent drug conjugates from the family of methyltrithio antibacterial and antitumor agents.
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: June 23, 1998
    Assignee: American Cyanamid Company
    Inventors: William James McGahren, Martin Leon Sassiver, George A. Ellestad, Philip R. Hamann, Lois M. Hinman, Janis Upeslacis
  • Targeted forms of methyltrithio antitumor agents
    Patent number: 5053394
    Abstract: This disclosure describes a method for constructing carrier-drug conjugates from the family of methyltrithio antibacterial and antitumor agents.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: October 1, 1991
    Assignee: American Cyanamid Company
    Inventors: George A. Ellestad, William J. McGahren, Martin L. Sassiver, Philip R. Hamann, Lois M. Hinman, Janis Upeslacis
  • Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones
    Patent number: 4732970
    Abstract: Antitumor amino acid and peptide derivatives of 1,4-bis[(aminoalkyl and hydroxyaminoalkyl)amino]-5,8-dihydroxyanthraquinones.
    Type: Grant
    Filed: June 13, 1986
    Date of Patent: March 22, 1988
    Assignee: American Cyanamid Company
    Inventors: Thomas L. Fields, Keith C. Murdock, Martin L. Sassiver, Janis Upeslacis
  • Antiatherosclerotic silanes
    Patent number: 4670421
    Abstract: This invention is concerned with novel 4-[(trialkylsilyl)alkylamino]phenyl compounds and their use as antiatherosclerotic agents.
    Type: Grant
    Filed: July 12, 1982
    Date of Patent: June 2, 1987
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Janis Upeslacis
  • Antiatherosclerotic diphenyl alkanamides
    Patent number: 4603145
    Abstract: This disclosure describes novel diaryl-alkanamides. These compounds are useful as pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: July 29, 1986
    Assignee: American Cyanamid Company
    Inventors: Vern G. DeVries, Robert G. Shepherd, Janis Upeslacis
  • Aralkanamidophenyl compounds
    Patent number: 4536346
    Abstract: This disclosure describes novel substituted aralkanamidobenzoic acids and analogs thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: August 20, 1985
    Assignee: American Cyanamid Company
    Inventors: Robert G. Shepherd, Janis Upeslacis
  • Arylalkylaminobenzoic acids
    Patent number: 4489094
    Abstract: This disclosure describes novel [Bis(phenyl or substituted phenyl)alkyl]amino benzoic acids, esters, and derivatives thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: December 18, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert G. Shepherd, Janis Upeslacis
  • Poly-cation salts of bis(or tris)[4-O-monohexose-oxy]-arylene sulfate derivatives
    Patent number: 4440758
    Abstract: Poly-cation salts of bis(or tris)[4-O-monohexose-oxy]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: April 3, 1984
    Assignee: American Cyanamid Company
    Inventors: Janis Upeslacis, Robert E. Schaub, Seymour Bernstein
  • Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives
    Patent number: 4435387
    Abstract: Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: March 6, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Polycation salts of bis (or tris) [4-O-polyhexose-oxy]-arylene sulfate derivatives
    Patent number: 4431637
    Abstract: Poly-cation salts of bis (or tris) [4-O-polyhexose-oxy]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: February 14, 1984
    Assignee: American Cyanamid Company
    Inventors: Janis Upeslacis, Robert E. Schaub, Seymour Bernstein
  • Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use
    Patent number: 4431636
    Abstract: Poly-cation salts of bis (4-O-polyhexaose-thio)-phenyl urea sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: February 14, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Poly-cation salts of bis(or tris)[4-0-monohexose-thio]-arylene sulfate derivatives
    Patent number: 4431638
    Abstract: Poly-cation salts of bis(or tris)[4-O-monohexose-thio]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: February 14, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Poly cation salts of monohexosethio (or oxy) alkyl diamides
    Patent number: 4404195
    Abstract: N,N'-Bis[4-[(2,3,4,6-tetra-O-sulfo-.alpha.(or .beta.)-D-glucopyranosyl)thio(or oxy)]phenyl]alkyl diamides, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process for the preparation of such intermediates and end products.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: September 13, 1983
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • N,N'-Bis(glucopyranosyl-D-glucopyranosyloxyphenyl)alkaline and methods of use
    Patent number: 4401661
    Abstract: N,N'-Bis[4-[2,3,6-tri-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-.alpha.(and .beta.)-D-glucopyranosyl)-.alpha.(and .beta.)-D-glucopyranosyloxy]phenyl]alkyldiamides and alkyldiamines, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: August 30, 1983
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Modulators of the complement system
    Patent number: 4399126
    Abstract: N,N'-Bis[4-[2,3,6,-tri-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-.alpha.(and .beta.)-D-glucopyranosyl)-.alpha.(and .beta.)-D-glucopyranosylthio or sulfinyl or sulfonyl]phenyl]alkyldiamides and alkyldiamines, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: August 16, 1983
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein