Abstract: An interactive method for radiation treatment planning is disclosed. The method applies to staged treatment planning algorithms, as used, for example, with arc therapy. It allows the user to hold the optimization algorithm at a stage in order to make adjustments to the objective function before advancing to the next stage. If adjustments are made, the user can revert to an earlier stage and re-run the optimization process using the adjusted objective function. While a hold is imposed, the treatment planning software may continue optimization at the current stage.

Abstract: Methods for developing and using treatment plans with improved modulation for radiation therapy are disclosed. The methods involve adding an extra component to the patient-related objective function in order to make the optimization algorithm used to develop the treatment plan arrive at a solution with increased modulation. The extra component may take many forms. For example, the user may specify that the treatment plan favor solutions using a range of monitor units. The present invention is particularly useful in conjunction with radiotherapy systems having multileaf collimators for beam shaping, and in connection with advanced radiotherapy techniques, such as IMRT and arc therapy.

Abstract: A treatment planning method and system for optimizing a treatment plan used to irradiate a treatment volume including a target volume, such as a tumor, is disclosed. In accordance with the present invention, gradients of a cost function that defines a treatment volume are back projected to a surface of interest. The method and system of preferred embodiments of the present invention calculate the gradients with respect to the dose received by the treatment volume. Machine parameters that are associated with the surface of interest may then be optimized based on the back projected gradients.

Abstract: A method of providing intensity modulated radiation therapy to a moving target is disclosed. The target moves periodically along a trajectory that is projected onto a multi-leaf collimator (MLC) plane. The MLC plane is divided into thin slices parallel to the movement of the target. The present invention optimizes the leaf sequence such that, within each slice, if a point receives radiation, all other points in that slice that receive the same amount or more fluence are also receiving radiation at the same time.

Abstract: An interactive method for radiation treatment planning is disclosed. The method applies to staged treatment planning algorithms, as used, for example, with arc therapy. It allows the user to hold the optimization algorithm at a stage in order to make adjustments to the objective function before advancing to the next stage. If adjustments are made, the user can revert to an earlier stage and re-run the optimization process using the adjusted objective function. While a hold is imposed, the treatment planning software may continue optimization at the current stage.

Abstract: A method of providing intensity modulated radiation therapy to a moving target is disclosed. The target moves periodically along a trajectory that is projected onto a multi-leaf collimator (MLC) plane. The MLC plane is divided into thin slices parallel to the movement of the target. The present invention optimizes the leaf sequence such that, within each slice, if a point receives radiation, all other points in that slice that receive the same amount or more fluence are also receiving radiation at the same time.

Abstract: Systems and methods of controlling the leaves of an aperture in radiation treatment are disclosed. In some embodiments, these systems and methods allow the delivery of different radiation fluences to different parts of a treatment volume in a single rotation of the aperture around the treatment volume. In some embodiments, different radiation fluences are achieved by radiating different parts of the treatment volume from opposing positions of the aperture around the treatment volume. In some embodiments, different radiation fluences are achieved by assigning different leaf pairs to radiate different parts of the treatment volume.

Abstract: Methods for developing and using treatment plans with improved modulation for radiation therapy are disclosed. The methods involve adding an extra component to the patient-related objective function in order to make the optimization algorithm used to develop the treatment plan arrive at a solution with increased modulation. The extra component may take many forms. For example, the user may specify that the treatment plan favor solutions using a range of monitor units. The present invention is particularly useful in conjunction with radiotherapy systems having multileaf collimators for beam shaping, and in connection with advanced radiotherapy techniques, such as IMRT and arc therapy.

Abstract: A treatment planning method and system for optimizing a treatment plan used to irradiate a treatment volume including a target volume, such as a tumor, is disclosed. In accordance with the present invention, gradients of a cost function that defines a treatment volume are back projected to a surface of interest. The method and system of preferred embodiments of the present invention calculate the gradients with respect to the dose received by the treatment volume. Machine parameters that are associated with the surface of interest may then be optimized based on the back projected gradients.

Abstract: A treatment planning method and system for optimizing a treatment plan used to irradiate a treatment volume including a target volume, such as a tumor, is disclosed. According to the method, two dose calculation algorithms are used to develop the optimized treatment plan. A first dose calculation algorithm is used to obtain substantially complete dose calculations and a second, incremental, dose calculation algorithm is used to make more limited calculations. The incremental calculations may be performed, for example, with less precision, less accuracy or less scope (e.g., focused on a specific subvolume within the treatment volume) in order to reduce the time required to achieve an optimized plan. Each of the dose calculation algorithms may be iterated a plurality of times, and different cutoff criteria can be used to limit the number of iterations in a given pass. A treatment planning system of the invention uses software for implementing the complete and incremental dose calculation algorithms.

Abstract: A method includes obtaining a first image, obtaining a second image, determining a deformation field using the first and second images, and determining a transformation matrix using the deformation field. A computer product having a set of instruction, an execution of which causes a process to be performed, the process comprising determining a deformation field using first and second images, and determining a transformation matrix using the deformation field. A system includes a computer-readable medium for storing a first image and a second image, and a processor configured to determine a deformation field using the first and second images, and determine a transformation matrix using the deformation field.

Abstract: A stochastic patient movement model and a dosage delivery plan are used to determine probabilities of dosages received by a target volume during a radiation treatment. The stochastic patient movement model is created by identifying possible sequences of patient positions during the treatment with probabilities specified for each. The dosage delivery plan specifies dosage levels and radiation locations over time. Accumulated dosages are calculated for each sequence of patient positions and the dosage delivery plan. The specified probability for each sequence is then correlated to the accumulated dosage for that sequence.

Abstract: Various embodiments of the invention include systems and methods for adapting a movement model based on an image captured during radiation treatment of a patient. The movement model may, for example, be used in radiotherapy to treat lung cancer. The movement model is typically based on a series of images of a patient captured over a period of time. The movement model and/or one or images included therein may be used to generate a reference image of the patient. The reference image is compared with an image of the patient optionally captured during treatment. The result of this comparison is used to adapt the movement model to conditions during the treatment.

Abstract: Systems and methods of controlling the leaves of an aperture in radiation treatment are disclosed. In some embodiments, these systems and methods allow the delivery of different radiation fluences to different parts of a treatment volume in a single rotation of the aperture around the treatment volume. In some embodiments, different radiation fluences are achieved by radiating different parts of the treatment volume from opposing positions of the aperture around the treatment volume. In some embodiments, different radiation fluences are achieved by assigning different leaf pairs to radiate different parts of the treatment volume.