Patents by Inventor Janni Mirosevich

Janni Mirosevich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymer based polynucleotide transfection agents
    Patent number: 8921111
    Abstract: The present invention provides a methodology for transfecting cells in vitro. In particular, cationic polymers and polynucleotide containing polyplexes comprising such polymers are provided.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: December 30, 2014
    Assignee: Intezyne Technologies
    Inventor: Janni Mirosevich
  • POLYMER BASED POLYNUCLEOTIDE TRANSFECTION AGENTS
    Publication number: 20140302607
    Abstract: The present invention provides a methodology for transfecting cells in vitro. In particular, cationic polymers and polynucleotide containing polyplexes comprising such polymers are provided.
    Type: Application
    Filed: January 27, 2014
    Publication date: October 9, 2014
    Applicant: Intezyne Technologies, Inc.
    Inventor: Janni Mirosevich
  • Polymeric micelles for polynucleotide encapsulation
    Patent number: 8747904
    Abstract: The present invention provides micelles having a polynucleotide encapsulated therein, the micelle comprising copolymers comprising hydrophobic moieties in a cationic complexing block. The invention further provides methods of preparing and using said micelles, and compositions thereof.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: June 10, 2014
    Assignee: Intezyne Technologies, Inc.
    Inventors: Janni Mirosevich, Gregoire Cardoen, Kevin N. Sill, Habib Skaff
  • PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY
    Publication number: 20130344117
    Abstract: The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.
    Type: Application
    Filed: March 13, 2013
    Publication date: December 26, 2013
    Applicant: INTEZYNE TECHNOLOGIES, INC
    Inventors: Janni Mirosevich, Kevin N. Sill, Gregoire Cardoen
  • POLYMERIC MICELLES FOR POLYNUCLEOTIDE ENCAPSULATION
    Publication number: 20130266617
    Abstract: The present invention provides micelles having a polynucleotide encapsulated therein, the micelle comprising copolymers comprising hydrophobic moieties in a cationic complexing block. The invention further provides methods of preparing and using said micelles, and compositions thereof.
    Type: Application
    Filed: August 21, 2012
    Publication date: October 10, 2013
    Applicant: Intezyne Technologies, Inc.
    Inventors: Janni Mirosevich, Gregoire Cardoen, Kevin N. Sill, Habib Skaff
  • ATTACHMENT OF BIOLOGICAL TARGETING GROUPS USING METAL FREE CLICK CHEMISTRY
    Publication number: 20120283410
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to click-functionalized targeting compounds and methods for using the same.
    Type: Application
    Filed: March 9, 2012
    Publication date: November 8, 2012
    Applicant: Intezyne Technologies, Incorporated
    Inventors: Janni Mirosevich, Kevin Sill
  • Polymeric micelles for polynucleotide encapsulation
    Patent number: 8287910
    Abstract: The present invention provides micelles having a polynucleotide encapsulated therein, the micelle comprising copolymers comprising hydrophobic moieties in a cationic complexing block. The invention further provides methods of preparing and using said micelles, and compositions thereof.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: October 16, 2012
    Assignee: Intezyne Technologies, Inc.
    Inventors: Janni Mirosevich, Gregoire Cardoen, Kevin N. Sill, Habib Skaff
  • PEGYLATED POLYPLEXES CONTAINING TWO OR MORE DIFFERENT POLYMERS FOR POLYNUCLEOTIDE DELIVERY
    Publication number: 20120237565
    Abstract: The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.
    Type: Application
    Filed: March 9, 2012
    Publication date: September 20, 2012
    Applicant: INTEZYNE TECHNOLOGIES, INCORPORATED
    Inventors: Janni Mirosevich, Kevin Sill
  • PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY
    Publication number: 20120148631
    Abstract: The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.
    Type: Application
    Filed: June 1, 2011
    Publication date: June 14, 2012
    Applicant: Intezyne Technologies, Incorporated
    Inventors: Janni Mirosevich, Gregoire Cardoen, Kevin N. Sill
  • CONTROLLED POLYPLEX ASSEMBLY
    Publication number: 20110256227
    Abstract: The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, polyplexes comprising polycations, polyanions, and polynucleotides are provided. The invention further provides methods of making and using said polyplexes.
    Type: Application
    Filed: April 14, 2011
    Publication date: October 20, 2011
    Applicant: Intezyne Technologies, Inc.
    Inventors: Janni Mirosevich, Kevin N. Sill
  • PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY
    Publication number: 20110229528
    Abstract: The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.
    Type: Application
    Filed: March 14, 2011
    Publication date: September 22, 2011
    Applicant: INTEZYNE TECHNOLOGIES, INCORPORATED
    Inventors: JANNI MIROSEVICH, KEVIN N. SILL, GREGOIRE CARDOEN
  • PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY
    Publication number: 20110142886
    Abstract: The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.
    Type: Application
    Filed: December 1, 2010
    Publication date: June 16, 2011
    Applicant: INTEZYNE TECHNOLOGIES, INCORPORATED
    Inventors: JANNI MIROSEVICH, GREGOIRE CARDOEN, KEVIN N. SILL
  • POLYMERS FOR POLYNUCLEOTIDE ENCAPSULATION
    Publication number: 20100292432
    Abstract: The present invention provides block copolymers comprising hydrophobic moieties in a cationic complexing block, methods of preparing the same, and intermediates thereto. The compounds are useful in a variety of applications such as the assembly of micellar polyion complexes. The invention further provides methods of using said compounds and compositions thereof.
    Type: Application
    Filed: April 29, 2010
    Publication date: November 18, 2010
    Applicant: Intezyne Technologies, Incorporated
    Inventors: Gregoire Cardoen, Kevin N. Sill, Janni Mirosevich, Habib Skaff
  • POLYMERIC MICELLES FOR POLYNUCLEOTIDE ENCAPSULATION
    Publication number: 20100278927
    Abstract: The present invention provides micelles having a polynucleotide encapsulated therein, the micelle comprising copolymers comprising hydrophobic moieties in a cationic complexing block. The invention further provides methods of preparing and using said micelles, and compositions thereof.
    Type: Application
    Filed: April 29, 2010
    Publication date: November 4, 2010
    Applicant: Intezyne Technologies, Incorporated
    Inventors: Janni Mirosevich, Gregoire Cardoen, Kevin N. Sill, Habib Skaff