Patents by Inventor Janos Botyanszki

Janos Botyanszki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIAZOLE-SUBSTITUTED IMIDAZO[1,2-A]PYRIMIDINES AS CGAS INHIBITORS
    Publication number: 20250092053
    Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.
    Type: Application
    Filed: December 3, 2024
    Publication date: March 20, 2025
    Applicant: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Adam K. CHARNLEY, Janos Botyanszki, Xiaoyang Dong, Philip Gareth Humphreys, Bryan Wayne King, Kimberly Katherine Marcus, Joseph Pero, Alexander Joseph Reif, Daohua Zhang, Attiq Rahman, Kenneth Allen Newlander, Kenneth Wiggall, Joshi Ramanjulu
  • Triazole-substituted imidazo[1,2-a]pyrimidines as cGAS inhibitors
    Patent number: 12247033
    Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.
    Type: Grant
    Filed: February 26, 2024
    Date of Patent: March 11, 2025
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Adam K. Charnley, Janos Botyanszki, Xiaoyang Dong, Philip Gareth Humphreys, Bryan Wayne King, Kimberly Katherine Marcus, Joseph Pero, Alexander Joseph Reif, Daohua Zhang, Attiq Rahman, Kenneth Allen Newlander, Kenneth Wiggall, Joshi Ramanjulu
  • THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF
    Publication number: 20240327399
    Abstract: Disclosed herein are compounds of Formula (I): that inhibit DNA Polymerase Theta (Pol?) activity, in particular inhibit Pol? activity by inhibiting ATP dependent helicase domain activity of Pol?. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Pol? such as cancer, including homologous recombination (HR) deficient cancers.
    Type: Application
    Filed: May 10, 2024
    Publication date: October 3, 2024
    Inventors: Janos BOTYANSZKI, Kevin Duffy, Young Eun Choi, Claire L. Neilan, Marcus M. Fischer
  • O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS
    Publication number: 20240287080
    Abstract: Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Pol?) activity, in particular inhibit Pol? activity by inhibiting ATP dependent helicase domain activity of Pol?. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Pol? such as cancer, including homologous recombination (HR) deficient cancers.
    Type: Application
    Filed: June 9, 2022
    Publication date: August 29, 2024
    Inventors: Paul A. BARSANTI, Kevin J. DUFFY, Brian G. LAWHORN, Firoz Ali JAIPURI, Daneil Lee SEVERANCE, Chenbo WANG, Nicholas David ADAMS, Janos BOTYANSZKI, Michael G. DARCY, Terence J. KIESOW, John J. MCATEE, Cuthbert MARTYR, Alexander BUTTRAGO SANTANILLA, Xinrong TIAN
  • TRIAZOLE-SUBSTITUTED IMIDAZO[1,2-A]PYRIMIDINES AS CGAS INHIBITORS
    Publication number: 20240228503
    Abstract: The present invention relates to compounds, compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.
    Type: Application
    Filed: February 26, 2024
    Publication date: July 11, 2024
    Inventors: Adam K. CHARNLEY, Janos BOTYANSZKI, Xiaoyang DONG, Philip Gareth HUMPHREYS, Bryan Wayne KING, Kimberly Katherine MARCUS, Joseph PERO, Alexander Joseph REIF, Daohua ZHANG, Attiq RAHMAN(Deceased), Kenneth Allen NEWLANDER, Kenneth WIGGALL, Joshi RAMANJULU
  • Compounds And Methods For Enhancing Innate Immune Responses
    Publication number: 20140249143
    Abstract: Provided are certain compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections.
    Type: Application
    Filed: October 19, 2012
    Publication date: September 4, 2014
    Applicant: GlaxoSmithKline LLC
    Inventors: Anna Lindsey Banka, Janos Botyanszki, Eric Gregory Burroughs, John George Catalano, Wendy Huang Chern, Hamilton D. Dickson, Margaret J. Gartland, Robert Hamatake, Hans Hofland, Jesse Daniel Keicher, Christopher Brooks Moore, John Bradford Shotwell, Matthew David Tallant, Jean-Philippe Therrien, Shihyun You
  • ANTIVIRAL COMPOUNDS
    Publication number: 20090197856
    Abstract: Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses.
    Type: Application
    Filed: December 19, 2008
    Publication date: August 6, 2009
    Inventors: Salvador G. Alvarez, Janos Botyanszki, Joseph de los Angeles, Jiping Fu, Roger Fujimoto, Joshua Michael Gralapp, Ronald Conrad Griffith, Peichao Lu, Son Minh Pham, Christopher Don Roberts, Franz Ulrich Schmitz, Mohindra Seepersaud, Ruben Tommasi, Adam Christopher Villa, Sompong Wattanasin, Aregahagn Yifru, Rui Zheng, Xiaoling Zheng
  • Bicyclic heteroaryl derivatives
    Patent number: 7511145
    Abstract: Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: March 31, 2009
    Assignee: Genelabs Technologies, Inc.
    Inventors: Franz Ulrich Schmitz, Christopher Don Roberts, Ronald Conrad Griffith, Janos Botyanszki, Mikail Hakan Gezginci, Joshua Michael Gralapp, Dong-Fang Shi, Sebastian Johannes Reinhard Liehr
  • BICYCLIC HETEROARYL DERIVATIVES
    Publication number: 20090081165
    Abstract: Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.
    Type: Application
    Filed: October 30, 2008
    Publication date: March 26, 2009
    Inventors: Franz Ulrich Schmitz, Christopher Don Roberts, Ronald Conrad Griffith, Janos Botyanszki, Mikail Hakan Gezginci, Joshua Michael Gralapp, Dong-Fang Shi, Sebastian Johannes Reinhard Liehr
  • ANTIVIRAL AGENTS
    Publication number: 20080051384
    Abstract: Disclosed are compounds and compositions of Formula (I) and their uses for treating Flaviviridae family virus infections.
    Type: Application
    Filed: July 12, 2007
    Publication date: February 28, 2008
    Inventors: Franz Schmitz, Christopher Roberts, Ronald Griffith, Janos Botyanszki, Son Pham
  • POLYCYCLIC VIRAL INHIBITORS
    Publication number: 20080045498
    Abstract: Disclosed are compounds and compositions of Formula (A) and their uses for treating Flaviviridae family virus infections.
    Type: Application
    Filed: July 19, 2007
    Publication date: February 21, 2008
    Inventors: Ronald Griffith, Christopher Roberts, Franz Schmitz, Janos Botyanszki, Rachel Marek, Dong-Fang Shi, Son Pham
  • 6-Membered aryl and heteroaryl derivatives for treating viruses
    Publication number: 20070032488
    Abstract: Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.
    Type: Application
    Filed: August 3, 2006
    Publication date: February 8, 2007
    Inventors: Janos Botyanszki, Dong-Fang Shi, Christopher Roberts, Franz Schmitz
  • Heteroaryl derivatives for treating viruses
    Publication number: 20060293320
    Abstract: Disclosed are compounds, compositions, and methods for treating Flaviviridae family virus infections.
    Type: Application
    Filed: June 22, 2006
    Publication date: December 28, 2006
    Inventors: Franz Schmitz, Janos Botyanszki, Christopher Roberts
  • Aromatic compounds possessing antifungal or antibacterial activity
    Patent number: 7141680
    Abstract: The present invention provides novel compounds possessing antibacterial, and/or antifungal activities. Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: November 28, 2006
    Assignee: Genelabs Technologies, Inc.
    Inventors: Janos Botyanszki, Dong-Fang Shi, Christopher Don Roberts, Mikail Hakan Gezginci, Stephen Corey Valdez, Sherwin Sattarzadeh
  • Bicyclic heteroaryl derivatives for treating viruses
    Publication number: 20060211698
    Abstract: Disclosed are compounds having formula I and related compositions and methods thereof. The compounds are useful for treating viral infections caused by the Flaviviridae family of viruses.
    Type: Application
    Filed: January 13, 2006
    Publication date: September 21, 2006
    Inventors: Janos Botyanszki, Christopher Roberts, Franz Schmitz, Joshua Gralapp, Ronald Griffith, Dong-Fang Shi, Martin Leivers, Rachel Brewster
  • Aromatic compounds and poly(oxyalkylene) containing aromatic compounds possessing antibacterial, antifungal or antitumor activity
    Patent number: 7064218
    Abstract: The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: June 20, 2006
    Assignee: Genelabs Technologies, Inc.
    Inventors: Natalia B. Dyatkina, Dong-Fang Shi, Christopher Don Roberts, Mark Douglas Velligan, Sebastian Johannes Reinhard Liehr, Janos Botyanszki, Wentao Zhang, Alexander Khorlin, Peter Harold Nelson, Joseph Martin Muchowski
  • Bicyclic heteroaryl derivatives
    Publication number: 20050187390
    Abstract: Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.
    Type: Application
    Filed: July 30, 2004
    Publication date: August 25, 2005
    Inventors: Franz Schmitz, Christopher Roberts, Ronald Griffith, Janos Botyanszki, Mikail Gezginci, Joshua Gralapp, Dong-Fang Shi, Sebastian Johannes Reinhard Liehr
  • Compounds possessing antibacterial, antifungal or antitumor activity
    Patent number: 6906103
    Abstract: The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: June 14, 2005
    Assignee: Genelabs Technologies, Inc.
    Inventors: Wentao Zhang, Sebastian Johannes Reinhard Liehr, Mark Douglas Velligan, Natalia B. Dyatkina, Janos Botyanszki, Dong-Fang Shi, Christopher Don Roberts, Alexander Khorlin, Peter Harold Nelson, Joseph Martin Muchowski
  • Compounds possessing antibacterial, antifungal or antitumor activity
    Patent number: 6849713
    Abstract: The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: February 1, 2005
    Assignee: Genelabs Technologies, Inc.
    Inventors: Wentao Zhang, Sebastian Johannes Reinhard Liehr, Mark Douglas Velligan, Natalia B. Dyatkina, Janos Botyanszki, Dong-Fang Shi, Christopher Don Roberts, Alexander Khorlin, Peter Harold Nelson, Joseph Martin Muchowski
  • Novel aromatic compounds possessing antifungal or antibacterial activity
    Publication number: 20040063645
    Abstract: The present invention provides novel compounds possessing antibacterial, antifungal, antiviral, anticancer, and/or antiparasitic activities. Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.
    Type: Application
    Filed: September 18, 2003
    Publication date: April 1, 2004
    Inventors: Janos Botyanszki, Dong-Fang Shi, Christopher Don Roberts, Mikail Hakan Gezginci, Stephen Corey Valdez, Sherwin Sattarzadeh