Patents by Inventor Janos Csorgei

Janos Csorgei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Industrial process for the synthesis of nomegestrol-acetate
    Patent number: 11274119
    Abstract: The invention relates to the last step of a synthetic process, in which Nomegestrol-acetate of formula (I) is synthesized from 17?-acetoxy-6-methylene-19-norpregn-4-ene-3,20-dione of formula (II) in the presence of Pd/C catalyst and acetic acid in hot ethanolic solution.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: March 15, 2022
    Assignee: Richter Gedeon Nyrt.
    Inventors: Sándor Mahó, János Csörgei, Csaba Sánta, Péter Vincze, László Balogh, János Horváth, Zoltán Béni
  • INDUSTRIAL PROCESS FOR THE SYNTHESIS OF NOMEGESTROL-ACETATE
    Publication number: 20210115084
    Abstract: The invention relates to the last step of a synthetic process, in which Nomegestrol-acetate of formula (I) is synthesized from 17?-acetoxy-6-methylene-19-norpregn-4-ene-3,20-dione of formula (II) in the presence of Pd/C catalyst and acetic acid in hot ethanolic solution.
    Type: Application
    Filed: December 15, 2017
    Publication date: April 22, 2021
    Inventors: Sándor MAHÓ, János CSÖRGEI, Csaba SÁNTA, Péter VINCZE, László BALOGH, János HORVÁTH, Zoltán BÉNI
  • Process for the production of 21-methoxy-11-beta-phenyl-19-nor-pregna-4,9-diene-3,20-dione derivatives
    Patent number: 9683010
    Abstract: The present invention relates to a process for the synthesis of compounds of formula (I), wherein the meaning of R is dimethylamino or acetyl group, using the compound of formula (III) or (IV), wherein the meaning of R? is dimethylamino or 2-methyl-1,3-dioxan-2-yl group, as starting material and methoxymethyl lithium as reagent.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: June 20, 2017
    Assignee: Richter Gedeon Nyrt.
    Inventors: Sándor Mahó, Csaba Sánta, János Csörgei, Gábor Szabó, Tamás Schäfer, Zoltán Béni
  • Industrial process for the synthesis of ulipristal acetate and its 4?-acetyl analogue
    Patent number: 9676814
    Abstract: The present invention relates to a new process for the synthesis of compounds of formula (I) (wherein the meaning of R is dimethylamino or acetyl group) using the compound of formula (II) (wherein the meaning of R is dimethylamino or 2-methyl-1,3-dioxolan-2-yl group) as starting material, as well as to the intermediate of the process.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: June 13, 2017
    Assignee: RICHTER GEDEON NYRT.
    Inventors: Sándor Mahó, Csaba Sánta, János Csörgei, János Horváth, Antal Aranyi, Zoltán Béni
  • Process for the production of 19-norpregn-4-en-3,20-dione-17?-ol(gestonorone) and intermediates therefor
    Patent number: 9562067
    Abstract: The present invention relates to a new stereoselective process for the synthesis of 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as to the new intermediates of the process. The 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one (gestonorone) is an important intermediate in the synthesis of the active ingredients having progestogen activity—such as gestonorone capronate and nomegestroi acetate. Formulas (I), (II) and (III).
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: February 7, 2017
    Assignee: RICHTER GEDEON NYRT.
    Inventors: János Csörgei, Anita Horváth, Csaba Sánta, Sándor Mahó, Zoltán Béni, János Horváth
  • PROCESS FOR THE PRODUCTION OF 21-METHOXY-11-BETA-PHENYL-19-NOR-PREGNA-4,9-DIENE-3,20-DIONE DERIVATIVES
    Publication number: 20160326211
    Abstract: The present invention relates to a process for the synthesis of compounds of formula (I), wherein the meaning of R is dimethylamino or acetyl group, using the compound of formula (III) or (IV), wherein the meaning of R? is dimethylamino or 2-methyl-1,3-dioxan-2-yl group, as starting material and methoxymethyl lithium as reagent.
    Type: Application
    Filed: February 16, 2015
    Publication date: November 10, 2016
    Inventors: Sándor MAHÓ, Csaba SÁNTA, János CSÖRGEI, Gábor SZABÓ, Tamás SCHÄFER, Zoltán BÉNI
  • Industrial Process for the Synthesis of Ulipristal Acetate and its 4'-Acetyl Analogue
    Publication number: 20160311849
    Abstract: The present invention relates to a new process for the synthesis of compounds of formula (I) (wherein the meaning of R is dimethylamino or acetyl group) using the compound of formula (II) (wherein the meaning of R is dimethylamino or 2-methyl-1,3-dioxolan-2-yl group) as starting material, as well as to the intermediate of the process.
    Type: Application
    Filed: October 1, 2014
    Publication date: October 27, 2016
    Applicant: RICHTER GEDEON NYRT.
    Inventors: Sándor MAHÓ, Csaba SÁNTA, János CSÖRGEI, János HORVÁTH, Antal ARANYI, Zoltán BÉNI
  • A PROCESS FOR THE PRODUCTION OF 19-NORPREGN-4-EN-3,20-DIONE-17ALPHA-OL(GESTONORONE) AND INTERMEDIATES THEREFOR
    Publication number: 20160297848
    Abstract: The present invention relates to a new stereoselective process for the synthesis of 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as to the new intermediates of the process. The 17(?)-17-acetyl-17-hydroxy-estr-4-en-3-one (gestonorone) is an important intermediate in the synthesis of the active ingredients having progestogen activity—such as gestonorone capronate and nomegestroi acetate. Formulas (I), (II) and (III).
    Type: Application
    Filed: December 15, 2014
    Publication date: October 13, 2016
    Inventors: János CSÖRGEI, Anita HORVÁTH, Csaba SÁNTA, Sándor MAHÓ, Zoltán BÉNI, János HORVÁTH
  • NOVEL CRYSTAL FORM OF AN ORGANIC COMPOUND AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20160220585
    Abstract: The present invention relates to novel crystalline Form II of 17?-acetoxy-21-methoxy-11?-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124), processes for the preparation thereof and pharmaceutical composition comprising it. Form II can be crystallized from different medium such as esters of C1-C4 alcohols and carboxylic acids, ketones, cyclohexane, acetonitrile, dimethylformamide, dimethyl sulfoxide, water and any mixture thereof.
    Type: Application
    Filed: December 28, 2015
    Publication date: August 4, 2016
    Inventors: Attila Balázs, János Csörgei, Ádám Demeter, Csaba Sánta
  • Crystal form of an organic compound and process for the preparation thereof
    Patent number: 9221870
    Abstract: The present invention relates to novel crystalline Form II of 17?-acetoxy-21-methoxy-11?-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124), processes for the preparation thereof and pharmaceutical compositions comprising it. Form II can be crystallized from different medium such as esters of C1-C4 alcohols and carboxylic acids, ketones, cyclohexane, acetonitrile, dimethylformamide, dimethyl sulfoxide, water and any mixture thereof.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: December 29, 2015
    Assignee: Richter Gedeon Nyrt.
    Inventors: Attila Balázs, János Csörgei, Ádám Demeter, Csaba Sánta
  • NOVEL CRYSTAL FORM OF AN ORGANIC COMPOUND AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20120142655
    Abstract: The present invention relates to novel crystalline Form II of 17?-acetoxy-21-methoxy-11?-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as CDB-4124), processes for the preparation thereof and pharmaceutical compositions comprising it. Form II can be crystallized from different medium such as esters of C1-C4 alcohols and carboxylic acids, ketones, cyclohexane, acetonitrile, dimethylformamide, dimethyl sulfoxide, water and any mixture thereof.
    Type: Application
    Filed: August 5, 2010
    Publication date: June 7, 2012
    Inventors: Attila Balázs, János Csörgei, Ádám Demeter, Csaba Sánta
  • Industrial method for the synthesis of 17-acetoxy-11?[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
    Patent number: 8183402
    Abstract: The present invention relates to a process for the synthesis of the 17-acetoxy-11?-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I): from 3,3-[1,2-etandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II):
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: May 22, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: József Bódi, György Visky, János Széles, Sándor Mahó, Csaba Sánta, János Csörgei, Zoltán Tuba, László Terdy, Csaba Molnár, Antal Aranyi, Zoltán Horváth, Gábor Balogh
  • Industrial process for the synthesis of 17?-acetoxy-11?-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process
    Patent number: 8110691
    Abstract: A new industrial process for the synthesis of solvate-free 17?-acetoxy-11?-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: February 7, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: Lajosné Dancsi, György Visky, Zoltán Tuba, János Csörgei, Csaba Molnár, Endréné Magyari
  • INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11beta-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS
    Publication number: 20100137622
    Abstract: The present invention relates to a process for the synthesis of the known 17-acetoxy-11-?-[4-(dimethyl amino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-ethandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II). Compound CDB-4124 belongs to the group of anti-hormones.
    Type: Application
    Filed: June 19, 2008
    Publication date: June 3, 2010
    Inventors: József Bódi, György Visky, János Széles, Sándor Mahó, Csaba Sánta, János Csörgei, Zoltán Tuba, László Terdy, Csaba Molnár, Antal Aranyi, Zoltán Horváth, Gábor Balogh
  • INDUSTRIAL PROCESS FOR THE SYNTHESIS OF 17alpha-ACETOXY-11beta-[4-(N,N-DIMETHYL-AMINO)-PHENYL]-19-NORPREGNA-4,9-DIENE-3,20-DIONE AND NEW INTERMEDIATES OF THE PROCESS
    Publication number: 20090187032
    Abstract: The present invention relates to a new industrial process for the synthesis of solvate-free 17?-acetoxy-11?-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process.
    Type: Application
    Filed: May 18, 2007
    Publication date: July 23, 2009
    Applicant: RICHTER GEDEON NYRT.
    Inventors: Lajosne Dancsi, Gyorgy Visky, Zoltan Tuba, Janos Csorgei, Csaba Molnar, Endrene Magyari
  • Novel steroid diols, pharmaceutical compositions containing them and process for preparing same
    Patent number: 5082835
    Abstract: The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen, hydroxyl or trifluoroacetoxy group;X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;R stands for hydrogen, benzoyl or C.sub.1-8 alkanoyl group; andrepresents a single or double bond between two adjacent carbon atoms,as well as pharmaceutical compositions containing these compounds and a process for their preparation.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: January 21, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar R.T.
    Inventors: Csaba Molnar, Gyorgy Hajos, Laszlo Szporny, Jozsef Toth, Arpad Kiraly, Anna Boor nee Mezei, Janos Csorgei, Kristina Szekely, Lilla Forgacs, Gyorgy Fekete, Bulcsu Herenyi, Sandor Holly, Jozsef Szunyog
  • Novel steroid derivatives, pharmaceutical compositions containing them and process for preparing same
    Patent number: 5053404
    Abstract: The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen or hydroxyl group;X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;R stands for hydrogen, benzoyl or C.sub.1-8 alkanoyl group;R.sup.1 and R.sup.2, which are the same or different, stand for hydrogen or a C.sub.1-4 alkyl group; or one of R.sup.1 and R.sup.2 is hydrogen and the other is phenyl group; or R.sup.1 and R.sup.2 together form a C.sub.4-5 alkylene group;means a single or double bond between two adjacent carbon atoms,as well as pharmaceutical compositions containing these compounds and a process for their preparation.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: October 1, 1991
    Assignee: Richter Gedeon Vegyeszeti Gyar R. T.
    Inventors: Csaba Molnar, Gyorgy Hajos, Laszlo Szporny, Jozsef Toth, Arpad Kiraly, Anna Boor nee Mezei, Janos Csorgei, Kristina Szekely, Lilla Forgacs, Gyorgy Fekete, Bulcsu Herenyi, Sandor Holly, Jozsef Szunyog