Patents by Inventor Janos Erdei
Janos Erdei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7439045Abstract: An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a submerged medium at a temperature within about 20-30° C. The pH of the fermentation medium is regulated to be at about 5.5-6.0 by feeding the fermentation medium with an assimilable carbon source, a mineral salt, or an acidic/alkali solution. Accordingly, the resulting fermentation broth contains an increased yield of highly purified pseudomonic acid A as the main component. The pseudomonic acid B as an impurity in the fermentation broth is significantly decreased.Type: GrantFiled: June 21, 2002Date of Patent: October 21, 2008Assignee: TEVA Gyógyszergyár Zártkörúen Müködö RészvénytársaságInventors: Eva Gulyas, Gabor Balogh, Janos Erdei, Peter Seress
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Publication number: 20080254520Abstract: The present invention relates to methods for reducing impurities of mycophenolic acid during fermentation by controlling the level of carbon source during fermentation of mycophenolic acid and for the isolation and use as a standard marker of the impurity homo-mycophenolic acid.Type: ApplicationFiled: April 11, 2008Publication date: October 16, 2008Inventors: Eva Gulyas, Gabor Balogh, Janos Erdei, Laszlo Toth, Boglarka Szikszai, Alexandr Jegorov, Jiri Faustmann
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Patent number: 7078223Abstract: A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20° C. and 30° C. containing organic nitrogen and carbon sources and, optionally, mineral salts.Type: GrantFiled: November 12, 2002Date of Patent: July 18, 2006Assignee: TEVA Gyógyszergyár Zártkörüen Müködö RészvénytársaságInventors: Valeria Szell, Ildiko Lang, Istvan Barta, Aniko Tedges, Karoly Albrecht, Julianna Mozes Nee Suto, Istvan M. Szabo, Magdolna Petroczki, Janos Erdei, Eva Gulyas, Gabor Balogh
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Publication number: 20050089978Abstract: The present invention provides a fermentation process for producing lipstatin comprising the steps of: a) preparing a fermentation medium containing a lipstatin-producing microorganism comprising an oil and an assimilable carbon source, wherein the wt/wt ratio of oil and assimilable carbon source is regulated to achieve an optimal lipstatin biosynthesis by the microorganism; and b) feeding the fermentation medium with an emulsifier, wherein the emulsifier provides an optimal viscosity for the fermentation medium and optimal pH during the fermentation to permit fermentation for lipstatin production. The disclosed process also provides a process for extracting a lipstatin from a fermentation broth.Type: ApplicationFiled: November 23, 2004Publication date: April 28, 2005Inventors: Janos Erdei, Eva Gulyas, Gabor Balogh, Laszlo Toth, Vilmos Keri, Andrea Csorvasi
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Patent number: 6844174Abstract: The present invention provides a fermentation process for producing lipstatin comprising the steps of: a) preparing a fermentation medium containing a lipstatin-producing microorganism comprising an oil and an assimilable carbon source, wherein the wt/wt ratio of oil and assimilable carbon source is regulated to achieve an optimal lipstatin biosynthesis by the microorganism; and b) feeding the fermentation medium with an emulsifier, wherein the emulsifier provides an optimal viscosity for the fermentation medium and optimal pH during the fermentation to permit fermentation for lipstatin production. The disclosed process also provides a process for extracting a lipstatin from a fermentation broth.Type: GrantFiled: December 4, 2002Date of Patent: January 18, 2005Assignee: Biogal Gyogyszergyar Rt.Inventors: Janos Erdei, Eva Gulyas, Gabor Balogh, Laszlo Toth, Vilmos Keri, Andrea Csorvasi
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Publication number: 20030138919Abstract: The present invention provides a fermentation process for producing lipstatin comprising the steps of: a) preparing a fermentation medium containing a lipstatin-producing microorganism comprising an oil and an assimilable carbon source, wherein the wt/wt ratio of oil and assimilable carbon source is regulated to achieve an optimal lipstatin biosynthesis by the microorganism; and b) feeding the fermentation medium with an emulsifier, wherein the emulsifier provides an optimal viscosity for the fermentation medium and optimal pH during the fermentation to permit fermentation for lipstatin production. The disclosed process also provides a process for extracting a lipstatin from a fermentation broth.Type: ApplicationFiled: December 4, 2002Publication date: July 24, 2003Inventors: Janos Erdei, Eva Gulyas, Gabor Balogh, Laszlo Toth, Vilmos Keri, Andrea Csorvasi
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Publication number: 20030100083Abstract: A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20° C. and 30° C.Type: ApplicationFiled: November 12, 2002Publication date: May 29, 2003Inventors: Valeria Szell, Ildiko Lang, Istvan Barta, Aniko Tedges, Karoly Albrecht, Julianna Mozes Nee Suto, Istvan M. Szabo, Magdolna Petroczki, Janos Erdei, Eva Gulyas, Gabor Balogh
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Publication number: 20030027292Abstract: An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a submerged medium at a temperature within about 20-30° C. The pH of the fermentation medium is regulated to be at about 5.5-6.0 by feeding the fermentation medium with an assimilable carbon source, a mineral salt, or an acidic/alkali solution. Accordingly, the resulting fermentation broth contains an increased yield of highly purified pseudomonic acid A as the main component. The pseudomonic acid B as an impurity in the fermentation broth is significantly decreased.Type: ApplicationFiled: June 21, 2002Publication date: February 6, 2003Inventors: Eva Gulyas, Gabor Balogh, Janos Erdei, Peter Seress
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Patent number: 6509177Abstract: A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20° C. and 30° C. containing organic nitrogen and carbon sources and, optionally, mineral salts.Type: GrantFiled: February 3, 2000Date of Patent: January 21, 2003Assignee: Biogal Gyogyszergyar Rt.Inventors: Valeria Szell, Ildiko Lang, Istvan Barta, Aniko Tedges, Karoly Albrecht, Julianna Mozes Nee Suto, Istvan M. Szabo, Magdolna Petroczki, Janos Erdei, Eva Gulyas, Gabor Balogh
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Patent number: 6506591Abstract: A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20° C. and 30° C. containing organic nitrogen and carbon sources and, optionally, mineral salts.Type: GrantFiled: October 11, 2001Date of Patent: January 14, 2003Assignee: Biogal Gyogyszergyar Rt.Inventors: Valeria Szell, Ildiko Lang, Istvan Barta, Aniko Tedges, Karoly Albrecht, Julianna Mozes Nee Suto, Istvan M. Szabo, Magdolna Petroczki, Janos Erdei, Eva Gulyas, Gabor Balogh
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Publication number: 20020197683Abstract: A metabolic controlled fermentation process has been developed for the production of carbamoyl tobramycin by the application of different Streptomyces tenebrarius strains in submerged cultures at a temperature within about 37-41° C. on a medium containing assimilable carbon and nitrogen sources, mineral salts and controlling the assimilable carbon and nitrogen sources by feeding in an optimal range. As a result of this invention a high yield production of carbamoyl tobramycin with high purity could be achieved.Type: ApplicationFiled: January 9, 2002Publication date: December 26, 2002Inventors: Istvan Bakondi-Kovacs, Ilona Csutoros Novotny, Janos Erdei, Gabor Balogh, Peter Seress
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Publication number: 20020042103Abstract: A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20° C. and 30° C. containing organic nitrogen and carbon sources and, optionally, mineral salts.Type: ApplicationFiled: October 11, 2001Publication date: April 11, 2002Inventors: Valeria Szell, Ildiko Lang, Istvan Barta, Aniko Tedges, Karoly Albrecht, Julianna Mozes Nee Suto, Istvan M. Szabo, Magdolna Petroczki, Janos Erdei, Eva Gulyas, Gabor Balogh
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Patent number: 5403728Abstract: The invention refers to a new microbial process for preparing .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy l-butyryloxy)-naphthalen-1-yl]-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methy lbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), ##STR1## by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25.degree. to 30.degree. C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.Type: GrantFiled: June 17, 1993Date of Patent: April 4, 1995Assignee: BIOGAL Gyogyszergyar RTInventors: Antonia Jekkel, Eva Ilkoy, Istvan M. Szabo, Gabor Ambrus, Attila Andor, Ilona Varga, Imre Moravcsik, Istvan Szabo, Janos Erdei, Kalman Polya, Andras Kiss, Laszlo Cseke, Karoly Nagy, Mihaly Kaszas, Lajos Kiss, Istvan Magyi, Edit Halasz, Gyorgy Santha
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Patent number: 5156960Abstract: The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25.degree. to 30.degree. C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.Type: GrantFiled: December 20, 1989Date of Patent: October 20, 1992Assignee: Biogal GyogyszergyarInventors: Antonia Jekkel nee Bokany, Gabor Ambrus, Eva Toth-Sarudy, Istvan Mihaly, Agota Hulber nee Dobos, Attila Andor, Karoly Albrecht, Kalman Konczol, Valeria Szell, Eva Tomori nee Joszt, Imre Moravcsik, Kalman Polya, Janos Erdei, Lajos Kiss, Bela Makadi, Karoly Nagy, Bela Palotas, Etelka Deli nee Konszky, Karoly Buzasi, Aniko Molnar nee Antal, Gyorgy Santha, Vilma Szaszhegyesi
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Patent number: 4906574Abstract: A fermenting device for culturing aerobic microorganisms equipped with a plurality of stirrer-agitators also includes a preferably conical baffle screen which is open at the top and the bottom and is spaced from the walls of the fermentor device, and is disposed between each agitator for guiding air dispersed by one agitator into the space under the next agitator for redispersion thereby. Suitably an annular guide member is disposed along the interior walls of the fermentor and under the baffle screen to improve the efficacy of the redispersion. The aerobic fermentation process involves the dispersing of air introduced into the fermentor by a rotated agitator and then conducting the dispersed air by a baffle screen and optional annular guide member to a next agitator for redispersion.Type: GrantFiled: June 10, 1988Date of Patent: March 6, 1990Assignee: Biogal GyogyszergyarInventors: Janos Erdei, Erno Karacsony, Laszlo Csermely, Jeno Szilagyi, Gyorgy Santha, Peter Seres
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Patent number: 4591379Abstract: The invention relates to plant growth regulators, that is, to compositions influencing the growth of plants. The compositions of the invention contain as active agent a 3,6-diamino-acridine N-glycoside of the formula (I) ##STR1## and/or its acid addition salt of the formula (II) ##STR2## in which formulae at least one of R.sub.1 and R.sub.2 stands for an .alpha.- and/or .beta.-(D)- and/or .alpha.- and/or .beta.-(L)-glucosyl, -galactosyl, -mannosyl, -xylosyl, -arabinosyl, -ribosyl, -6-desoxyglucosyl, -6-desoxygalactosyl, -ramnosyl, -maltosyl, -2-acetamido-2-desoxyglucosyl, -lactosyl, -cellobiosyl, -genciobiosyl or -laminaribiosyl group and the other one represents either a hydrogen atom or one of the enumerated sugar groups;A is a residue of an acid; andp stands for 1, 2 or 3.Type: GrantFiled: March 23, 1984Date of Patent: May 27, 1986Assignee: Biogal GyogyszergyarInventors: Antal Kovacs, Janos Erdei, Karoly Kovats, Laszlo Polya, Karoly Pasztor, Janos Nagy, Pal Pepo, Peter Pepo, Gyorgy Kiss, Istvan Kajati
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Patent number: 4462993Abstract: The invention relates to novel aminoacridine-.alpha.,.beta.-(D)- and -(L)-N-glycoside derivatives, the salts thereof and to a novel process for the preparation of such compounds and salts. The novel compounds have the formula I ##STR1## wherein R is hydrogen or a group of the formula II ##STR2## wherein n=0 or 1, p=1 or 2, A.sup.-p is an anion, preferably halogenide, R.sup.1 is hydrogen or a methyl group andR.sup.2 is hydrogen or a sugar residue, or R is dimethylamine,and the two substituentsX and X.sup.1 are identical or different and stand for hydrogen, a group of the formula II, dimethylamine, halogen, a C.sub.1-4 alkyl group, a C.sub.1-4 alkoxy group, for a nitro-, cyano-, carbomethoxy-, carbamoyl-, phenyl- or a C.sub.1-4 alkylphenyl group,with the restriction that at least one of the substituents R, X and X.sup.1 represents a group of formula II with R.sup.2 =sugar residue, andR.sup.3 is hydrogen or a C.sub.1-5 alkyl group.Type: GrantFiled: March 1, 1982Date of Patent: July 31, 1984Assignee: Biogal GyogyszergyarInventors: Antal Kovacs, Andras Liptak, Pal Nanasi, Lorant Janossy, Istvan Csernus, Janos Erdei, Istvan Kaszab, Kalman Polya, Andras Neszmelyi