Patents by Inventor Janos Galambos

Janos Galambos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 2-bromo-.alpha.-ergocryptine
    Patent number: 4697017
    Abstract: The invention relates to a novel process for the preparation of 2-bromo-.alpha.-ergocryptine and its acid addition salt by brominating .alpha.-ergocryptine in such a way that the bromination is carried out at room temperature by using a dimethylsulphoxide-hydrogen bromide mixture containing no more 0.02% of water and, if desired, converting the thus-obtained 2-bromo-.alpha.-ergocryptine to an acid addition salt in a known manner.
    Type: Grant
    Filed: May 30, 1986
    Date of Patent: September 29, 1987
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Gabor Megyeri, Tibor Keve, Janos Galambos, Lajos Kovacs, Jr., Bela Stefko, Erik Bogsch, Ferenc Trischler
  • Pharmaceutical compositions with a neuroleptic action and process for preparing same
    Patent number: 4681887
    Abstract: The invention relates to pharmaceutical compositions with a neuroleptic action as well as to a process for preparing these compositions.The active ingredients of the compositions of the invention are 2-halo-6-methyl-9-ergolene derivatives of the formula (I), ##STR1## wherein X represents a chlorine, bromine or iodine atom as well as their acid addition salts.The compositions of the invention contain an effective dose of compound of the general formula (I) or an acid addition salt thereof.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: July 21, 1987
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Gabor Megyeri, Tibor Keve, Bela Stefko, Erik Bogsch, Janos Galambos, Anna Kassainee Zieger, Ferenc Trischler, Eva Palosi, Dora Groo, Egon Karpati, Zsolt Szombathelyi, Laszlo Szporny, Bela Kiss, Istvan Laszlovszky, Erzsebet Lapis
  • Apovincaminol derivative
    Patent number: 4680397
    Abstract: The invention relates to new apovincaminol derivatives of the formula /I/ ##STR1## wherein R.sub.1 is hydrogen, nitro or halogen,R.sub.2 is a substituted or unsubstituted alkyl or phenyl group,R.sub.3 and R.sub.4 together form a valency bond or each independently represents hydrogen, hydroxyl or an --OR.sub.5 group, in whichR.sub.5 is substituted or unsubstituted alkanoyl or benzoyl group,with the proviso that if R.sub.2 stands for a 3,4,5-trimethoxyphenyl group and R.sub.1 is hydrogen, R.sub.3 and R.sub.4 together do not form a valency bond, or if R.sub.2 is a 3,4,5-trimethoxyphenyl group and R.sub.3 and R.sub.4 both are hydrogen, R.sub.1 is other than hydrogen, nitro or bromine, and acid addition salts thereof.The compounds may be used in the therapy of various skin diseases accompanied by a pathological cell proliferation, preferably psoriasis.
    Type: Grant
    Filed: April 25, 1985
    Date of Patent: July 14, 1987
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Tibor Keve, Bela Zsadon, Gyorgy Fekete, Janos Galambos, Margit Barta nee Bukovecz, Laszlo Szporny, Lilla Forgacs, Arpad Kiraly, Gyongyver Soos, Bela Kiss, Maria Zajer nee Balazs
  • 1.alpha.-Ethyl-1.beta.-(2'-alkoxy carbonyl-2'-hydroxyiminoethyl)-10-methoxy 1,2,3,4,6,7,12,12.beta.-octahydroindolo(2,3A)quinolizines
    Patent number: 4429129
    Abstract: The invention relates to a new process for the preparation of alkoxyvincaminic acid esters of the formula (I) ##STR1## and/or alkoxyapovincaminic acid esters of the formula (II) ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 independently stand for alkyl groups having from one to 6 carbon atoms.The compounds of the formulae (I) and (II) are pharmaceutically active, thus some of them show psychostimulant activity.
    Type: Grant
    Filed: August 20, 1982
    Date of Patent: January 31, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt
    Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Tibor Keve, Lajos Dancsi, Janos Galambos, Ferenc Vezekenyi, Tibor Acs
  • Polycyclic compounds containing a double bond in the D-ring pharmaceutical compositions containing them, and methods of treating psoriasis with them
    Patent number: 4424223
    Abstract: The invention relates to the new 17,18-dehydro-apovincaminol-3',4',5'-trimethoxy-benzoate of formula (I) ##STR1## and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of these new compounds. Still another aspect of the invention is a pharmaceutical composition for treating psoriasis.
    Type: Grant
    Filed: February 4, 1982
    Date of Patent: January 3, 1984
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Tibor Keve, Bela Zsadon, Gyorgy Fekete, Csaba Lorincz, Janos Galambos, Maria Zajer nee Balazs, Lilla Forgach, Egon Karpati, Arpad Kiraly, Gyongyver Kiraly nee Soos, Laszlo Szporny, Bela Rosdy
  • Nitro-substituted polycyclic derivatives useful in the treatment of psoriasis
    Patent number: 4419359
    Abstract: The present invention relates to the compounds of the Formulae 1a and 1b and pharmaceutically acceptable acid addition salts thereof.The new 9-nitro-apovincaminol-3',4',5'-trimethoxybenzoate of the Formula 1a ##STR1## and the 11-nitro-apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 1b ##STR2## and pharmaceutically acceptable acid addition salts thereof can be prepared by nitrating the apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 11, ##STR3## if desired separating the mixture of the compounds of the Formulae 1a and 1b thus obtained into its components, if desired converting a compound of the Formula 1a or 1b thus obtained into pharmaceutically acceptable acid addition salts thereof.The new compounds of the present invention can be used in therapy in the treatment of psoriasis.
    Type: Grant
    Filed: February 4, 1982
    Date of Patent: December 6, 1983
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Tibor Keve, Gyorgy Fekete, Csaba Lorincz, Janos Galambos, Bela Zsadon, Maria Zajer nee Balazs, Lilla Forgach, Egon Karpati, Arpad Kiraly, Gyongyver Kiraly nee Soos, Laszlo Szporny, Bela Rosdy