Patents by Inventor Janssen Pharmaceutica NV

Janssen Pharmaceutica NV has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS
    Publication number: 20140066422
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, Y, R2, R3, and Ra are defined herein.
    Type: Application
    Filed: February 13, 2013
    Publication date: March 6, 2014
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • FUSED CYCLOPENTYL ANTAGONISTS OF CCR2
    Publication number: 20140018356
    Abstract: The present invention comprises compounds of Formula (I). wherein: R0, R1, R2, R3, R4, R5, and A are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
    Type: Application
    Filed: April 4, 2013
    Publication date: January 16, 2014
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • Process for the preparation of substituted pyrimidine derivatives
    Publication number: 20130225816
    Abstract: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 29, 2013
    Applicant: Janssen Pharmaceutica NV
    Inventor: Janssen Pharmaceutica NV
  • AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20130217669
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
    Type: Application
    Filed: March 18, 2013
    Publication date: August 22, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • TRICYCLIC INDOLE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS
    Publication number: 20130210806
    Abstract: The present invention is directed to tricyclic indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.
    Type: Application
    Filed: February 14, 2013
    Publication date: August 15, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • Use of a histamine H4 antagonist for the treatment of post-operative adhesions
    Publication number: 20130202685
    Abstract: The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering a histamine H4 receptor antagonist, systemically, directly to tissue surfaces in the body cavity, or both, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 8, 2013
    Applicant: Janssen Pharmaceutica NV
    Inventor: Janssen Pharmaceutica NV
  • DI-AZETIDINYL DIAMIDE AS MONOACYLGLCEROL LIPASE INHIBITORS
    Publication number: 20130196969
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.
    Type: Application
    Filed: March 13, 2013
    Publication date: August 1, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • AMINO-PYRROLIDINE-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20130196970
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R1, and R2 are defined herein.
    Type: Application
    Filed: March 13, 2013
    Publication date: August 1, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • DI-AZETIDINYL DIAMIDE AS MONOACYLGLCEROL LIPASE INHIBITORS
    Publication number: 20130196968
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.
    Type: Application
    Filed: March 13, 2013
    Publication date: August 1, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • HETEROAROMATIC AND AROMATIC PIPERAZINYL AZETIDINYL AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20130184251
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the inhibition of MGL, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, r, R2 and Z are defined herein.
    Type: Application
    Filed: March 4, 2013
    Publication date: July 18, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • 5-HT2B RECEPTOR ANTAGONISTS
    Publication number: 20130172386
    Abstract: The present invention relates to novel fluorinated piperidine derivatives having antagonistic activity at the 5-HT2B receptor, pharmaceutical compositions comprising these compounds and their use as a medicine.
    Type: Application
    Filed: February 28, 2013
    Publication date: July 4, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
    Publication number: 20130158258
    Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: February 12, 2013
    Publication date: June 20, 2013
    Applicant: Janssen Pharmaceutica NV
    Inventor: Janssen Pharmaceutica NV
  • 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
    Publication number: 20130158259
    Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: February 13, 2013
    Publication date: June 20, 2013
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventor: JANSSEN PHARMACEUTICA NV
  • AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20130137674
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
    Type: Application
    Filed: January 25, 2013
    Publication date: May 30, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS
    Publication number: 20130131401
    Abstract: The present invention is a process for the preparation of chymase modulators, useful in the treatment of inflammatory and serine protease mediated disorders.
    Type: Application
    Filed: January 15, 2013
    Publication date: May 23, 2013
    Applicant: Janssen Pharmaceutica, NV
    Inventor: Janssen Pharmaceutica, NV
  • AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20130123232
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
    Type: Application
    Filed: December 18, 2012
    Publication date: May 16, 2013
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventor: JANSSEN PHARMACEUTICA NV
  • AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20130123233
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
    Type: Application
    Filed: December 18, 2012
    Publication date: May 16, 2013
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventor: JANSSEN PHARMACEUTICA NV
  • AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20130102585
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
    Type: Application
    Filed: December 17, 2012
    Publication date: April 25, 2013
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventor: Janssen Pharmaceutica NV
  • MONOACYLGLYCEROL LIPASE INHIBITORS FOR THE TREATMENT OF METABOLIC DISEASES AND RELATED DISORDERS
    Publication number: 20130085129
    Abstract: Disclosed are compounds, compositions and methods for treating metabolic diseases, including obesity and diabetes, and for reducing weight gain. Such compounds are represented by formula (I) as follows: wherein Y and Z are defined herein.
    Type: Application
    Filed: September 27, 2012
    Publication date: April 4, 2013
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventor: JANSSEN PHARMACEUTICA NV
  • MONOACYLGLYCEROL LIPASE INHIBITORS FOR THE TREATMENT OF METABOLIC DISEASES AND RELATED DISORDERS
    Publication number: 20130085130
    Abstract: Disclosed are compounds, compositions and methods for treating metabolic diseases, including obesity and diabetes. Such compounds are represented by formula (I) as follows: wherein Y and Z are defined herein.
    Type: Application
    Filed: September 27, 2012
    Publication date: April 4, 2013
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventor: JANSSEN PHARMACEUTICA NV