Patents by Inventor Janus S. Larsen

Janus S. Larsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL POTASSIUM CHANNEL INHIBITORS
    Publication number: 20240034717
    Abstract: The present invention relates to novel compounds, pharmaceutical compositions comprising such compounds and their use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.
    Type: Application
    Filed: September 21, 2021
    Publication date: February 1, 2024
    Inventors: David Tristram BROWN, Palle CHRISTOPHERSEN, Thomas Amos JACOBSEN, Janus S. LARSEN, Pernille Hartveit POULSEN, Dorte STRØBAEK
  • GABAA receptor ligand
    Patent number: 11396510
    Abstract: The present invention relates to 2-(3-(3-(2,4-dimethoxypyrimidin-5-yl)phenyl)-3H-imidazo[4,5-b]pyridin-6-yl)propan-2-ol, which is useful as a GABA receptor modulator. In one embodiment, said compound is useful in the treatment of pain, neuropathic pain and/or itch.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: July 26, 2022
    Assignee: Saniona A/S
    Inventors: Janus S. Larsen, Dipak Amrutkar, Thomas Amos Jacobsen, Tino Dyhring, Karin Sandager Nielsen
  • NOVEL POTASSIUM CHANNEL INHIBITORS
    Publication number: 20220169602
    Abstract: The present invention relates to novel compounds, pharmaceutical compositions comprising such compounds and their use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.
    Type: Application
    Filed: March 20, 2020
    Publication date: June 2, 2022
    Inventors: David Tristram BROWN, Palle CHRISTOPHERSEN, Thomas Amos JACOBSEN, Janus S. LARSEN, Pernille Hartveit Poulsen, Dorte STRØBAEK
  • A GABAA Receptor Ligand
    Publication number: 20210332042
    Abstract: The present invention relates to 2-(3-(3-(2,4-dimethoxypyrimidin-5-yl)phenyl)-3H- imidazo[4,5-b]pyridin-6-yl)propan-2-ol, which is useful as a GABA receptor modulator. In one embodiment, said compound is useful in the treatment of pain, neuropathic pain and/or itch.
    Type: Application
    Filed: September 13, 2019
    Publication date: October 28, 2021
    Inventors: Janus S. LARSEN, Dipak AMRUTKAR, Thomas Amos JACOBSEN, Tino DYHRING, Karin Sandager NIELSEN
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 8492408
    Abstract: The present application discloses novel benzimidazole derivatives and their use as modulators of the GABAA receptor complex. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: July 23, 2013
    Assignee: Aniona APS
    Inventors: Janus S. Larsen, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 8288418
    Abstract: Benzimidazole derivatives, pharmaceutical compositions containing them, and methods of treatment therewith involving modulation of the GABAA receptor complex. The compounds have the formula I: wherein the variables are as described in the specification. The compounds are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: October 16, 2012
    Assignee: Neurosearch A/S
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX
    Publication number: 20110257230
    Abstract: The present application discloses novel benzimidazole derivatives and their use as modulators of the GABAA receptor complex. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: November 13, 2009
    Publication date: October 20, 2011
    Applicant: NEUROSEARCH A/S
    Inventors: Janus S. Larsen, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX
    Publication number: 20110257210
    Abstract: The present application discloses novel benzimidazole derivatives of general formula (I) or an N-oxide thereof, any of its stereoisomers or any mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein R represents a pyridyl or pyrimidyl group; which pyridyl or pyrimidyl group is optionally substituted with one or more substituents independently selected from the group consisting of: halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, alkyl, hydroxy, hydroxyalkyl and alkoxy, and their use as modulators of the GABAA receptor complex. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: November 13, 2009
    Publication date: October 20, 2011
    Applicant: NEUROSEARCH A/S
    Inventors: Janus S. Larsen, Philip K. Ahring, Elsebet ?stergaard Nielsen, Naheed Mirza
  • Imidazole derivatives for the treatment of anxiety and related diseases
    Patent number: 8030339
    Abstract: This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: October 4, 2011
    Assignee: Neurosearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elsebet Østergaard Nielsen
  • BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX
    Publication number: 20110118259
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Application
    Filed: January 20, 2011
    Publication date: May 19, 2011
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Ostergaard Nielsen, Naheed Mirza
  • Imidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7939556
    Abstract: This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: May 10, 2011
    Assignee: Neurosearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elsebet Østergaard Nielsen
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7923464
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: April 12, 2011
    Assignee: Neurosearch A/S
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7902230
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: March 8, 2011
    Assignee: Neurosearch A/S
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • Imidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7858649
    Abstract: This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are of the general formula (I) and include any of its stereoisomers, any mixture of its stereoisomers, and pharmaceutically acceptable salts thereof. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: December 28, 2010
    Assignee: Neurosearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elsebet Østergaard Nielsen
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7851490
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: December 14, 2010
    Assignee: Neurosearch A/S
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • Benzimidazole derivatives and their use for modulating the GABAreceptor complex
    Patent number: 7776900
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Grant
    Filed: April 18, 2006
    Date of Patent: August 17, 2010
    Assignee: Neurosearch A/S
    Inventors: Lene Teuber, Janus S. Larsen, Philip K. Ahring, Elsebet Østergaard Nielsen, Naheed Mirza
  • Imidazole Derivatives for the Treatment of Anxiety and Related Diseases
    Publication number: 20090233929
    Abstract: This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Application
    Filed: October 12, 2006
    Publication date: September 17, 2009
    Applicant: NeuroSearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elsebet Ostergaard Nielsen
  • IMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA ALPHA RECEPTOR COMPLEX
    Publication number: 20090209597
    Abstract: This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Application
    Filed: October 12, 2006
    Publication date: August 20, 2009
    Applicant: NeuroSearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elsebet Ostergaard Nielsen
  • Imidazole Derivatives and their use for Modulating the Gabaa Receptor Complex
    Publication number: 20090163566
    Abstract: This invention relates to novel imidazole derivatives of the general formula (I): pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Application
    Filed: October 12, 2006
    Publication date: June 25, 2009
    Applicant: NeuroSearch A/S
    Inventors: William Dalby Brown, Janus S. Larsen, Lene Teuber, David Tristram Brown, Philip K. Ahring, Naheed Mirza, Elseber Østergaard Nielsen
  • Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex
    Publication number: 20090062304
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Application
    Filed: April 18, 2006
    Publication date: March 5, 2009
    Inventors: Lene Teuber, Janus S. Larsen, Philip K. Ahring, Elsebet Ostergaard Nielsen, Naheed Mirza