Patents by Inventor Janusz Marek Bujnicki

Janusz Marek Bujnicki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sequence-specific engineered ribonuclease H and the method for determining the sequence preference of DNA-RNA hybrid binding proteins
    Patent number: 9353358
    Abstract: The subject of the invention is the ribonuclease which cleaves RNA strand in DNA-RNA hybrids, wherein ribonuclease comprises fusion protein comprising catalytic domain of RNase HI (RNase HI) or derivative thereof with a zinc finger DNA-RNA hybrid binding domain, and wherein the zinc finger binding domain has the ability to bind to specific sequences in the DNA-RNA hybrid. The invention also relates to new methods for determination of the sequence preference of DNA-RNA hybrid binding protein(s) or its domain(s) and allows determining the sequence recognized by sequence specific binding protein in the DNA-RNA hybrid.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: May 31, 2016
    Assignee: MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ
    Inventors: Janusz Marek Bujnicki, Agata Agnieszka Sulej, Krzysztof Jerzy Skowronek, Marcin Nowotny
  • dsRNA endoribonucleases
    Patent number: 9238805
    Abstract: The invention relates to a new double-stranded RNA endoribonuclease, its derivative and/or variant, which has a loop locating in and interacting with the major groove of the double-stranded RNA, exhibiting sequence specific properties in the double-stranded RNA cleavage.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: January 19, 2016
    Assignee: Miedzynarodowy Instytut Biologii Molekulamej I Komorkowej
    Inventors: Janusz Marek Bujnicki, Krzysztof Jerzy Skowronek, Dariusz Pianka, Agata Agnieszka Sulej
  • SEQUENCE-SPECIFIC ENGINEERED RIBONUCLEASE H AND THE METHOD FOR DETERMINING THE SEQUENCE PREFERENCE OF DNA-RNA HYBRID BINDING PROTEINS
    Publication number: 20140094385
    Abstract: The subject of the invention is the ribonuclease which cleaves RNA strand in DNA-RNA hybrids, wherein ribonuclease comprises fusion protein comprising catalytic domain of RNase HI (RNase HI) or derivative thereof with a zinc finger DNA-RNA hybrid binding domain, and wherein the zinc finger binding domain has the ability to bind to specific sequences in the DNA-RNA hybrid. The invention also relates to new methods for determination of the sequence preference of DNA-RNA hybrid binding protein(s) or its domain(s) and allows determining the sequence recognized by sequence specific binding protein in the DNA-RNA hybrid.
    Type: Application
    Filed: December 3, 2013
    Publication date: April 3, 2014
    Applicant: MIEDZYNARODOWY INSTYUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ
    Inventors: Janusz Marek Bujnicki, Agata Agnieszka Sulej, Krzysztof Jerzy Skowronek, Marcin Nowotny
  • dsRNA ENDORIBONUCLEASES
    Publication number: 20140087427
    Abstract: The invention relates to a new double-stranded RNA endoribonuclease, its derivative and/or variant, which has a loop locating in and interacting with the major groove of the double-stranded RNA, exhibiting sequence specific properties in the double-stranded RNA cleavage.
    Type: Application
    Filed: November 25, 2013
    Publication date: March 27, 2014
    Applicant: Miedzynarodowy Instytut Biologii Molekulamej I Komorkowej
    Inventors: Janusz Marek Bujnicki, Krzysztof Jerzy Skowronek, Dariusz Pianka, Agata Agnieszka Sulej