Patents by Inventor Janusz Puc

Janusz Puc has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EpCAM antibody and CAR-T cells
    Patent number: 11707487
    Abstract: The present invention provides EpCAM antibodies with different affinities. The present invention also provides chimeric antigen receptors (CARs) specific to EpCAM. CAR T cells comprising human EpCAM scFv having a low and sufficient affinity to EpCAM can avoid targeting healthy tissues with low EpCAM expression while exhibiting long-term efficacy against tumor tissues with high EpCAM expression. The present invention also relates to an adoptive cell therapy method for treating cancer by administering the CAR-T cells comprising human EpCAM scFv to a subject suffering from cancer, whereby the CAR T cells bind to the cancer cells overexpressing EpCAM and kill the cancer cells.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: July 25, 2023
    Assignee: AffyImmune Therapeutics, Inc.
    Inventors: Huan Yang, Moonsoo Jin, Janusz Puc
  • EPCAM ANTIBODY AND CAR-T CELLS
    Publication number: 20210317229
    Abstract: The present invention provides EpCAM antibodies with different affinities. The present invention also provides chimeric antigen receptors (CARs) specific to EpCAM. CAR T cells comprising human EpCAM scFv having a low and sufficient affinity to EpCAM can avoid targeting healthy tissues with low EpCAM expression while exhibiting long-term efficacy against tumor tissues with high EpCAM expression. The present invention also relates to an adoptive cell therapy method for treating cancer by administering the CAR-T cells comprising human EpCAM scFv to a subject suffering from cancer, whereby the CAR T cells bind to the cancer cells overexpressing EpCAM and kill the cancer cells.
    Type: Application
    Filed: April 13, 2021
    Publication date: October 14, 2021
    Inventors: Huan Yang, Moonsoo Jin, Janusz Puc