Patents by Inventor Janusz Sadowski
Janusz Sadowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10495571Abstract: A method for monitoring surface phenomena includes measuring a first surface plasmon resonance angle value (?SPR,REF) of a sample region (REG1), measuring a first critical angle value (?TIR,REF) of the sample region (REG1), causing a change of surface concentration (cM1,SRF) of an analyte (M1) at the sample region (REG1), changing the bulk composition at the sample region (REG1), measuring a second surface plasmon resonance angle value (?SPR(t)) of the sample region (REG1), measuring a second critical angle value (?TIR(t)) of the sample region (REG1), and determining an indicator value (?AUX(t)) indicative of the change of the surface concentration (cM1,SRF), wherein the indicator value (?AUX(t)) is determined from the second surface plasmon resonance angle value (?SPR(t)) by compensating an effect of the bulk composition, and wherein the magnitude (?COMP) of said effect is determined by using the second critical angle value (?TIR(t)).Type: GrantFiled: February 18, 2015Date of Patent: December 3, 2019Assignee: BioNavis OyInventors: Janusz Sadowski, Niko Granqvist, Jussi Tuppurainen, Annika Jokinen
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Publication number: 20170067826Abstract: A method for monitoring surface phenomena includes measuring a first surface plasmon resonance angle value (?SPR,REF) of a sample region (REG1), measuring a first critical angle value (?TIR,REF) of the sample region (REG1), causing a change of surface concentration (cM1,SRF) of an analyte (M1) at the sample region (REG1), changing the bulk composition at the sample region (REG1), measuring a second surface plasmon resonance angle value (?SPR(t)) of the sample region (REG1), measuring a second critical angle value (?TIR(t)) of the sample region (REG1), and determining an indicator value (?AUX(t)) indicative of the change of the surface concentration (cM1,SRF), wherein the indicator value (?AUX(t)) is determined from the second surface plasmon resonance angle value (?SPR(t)) by compensating an effect of the bulk composition, and wherein the magnitude (?COMP) of said effect is determined by using the second critical angle value (?TIR(t)).Type: ApplicationFiled: February 18, 2015Publication date: March 9, 2017Inventors: Janusz SADOWSKI, Niko GRANQVIST, Jussi TUPPURAINEN, Annika JOKINEN
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Patent number: 7701582Abstract: A method and a device for carrying out surface plasmon resonance measurement. A beam of electromagnetic radiation is produced by a source of electromagnetic radiation. The beam of electromagnetic radiation is directed through a prism onto a material layer in an angle of incidence, which material layer covers a planar surface of the prism. A resonance phenomenon is caused. A beam of reflected electromagnetic radiation is produced and directed by the surface to a detector for detecting the level of intensity of the beam of reflected electromagnetic radiation. The change of intensity of the beam of reflected electromagnetic radiation, caused by the surface resonance phenomenon, is measured. The beam of reflected electromagnetic radiation is reflected with a mirror to the detector.Type: GrantFiled: November 19, 2003Date of Patent: April 20, 2010Assignee: Beanor OyInventor: Janusz Sadowski
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Patent number: 7510882Abstract: In a method for analysis biomolecules (3) attached to a solid surface of a substrate (1) are used for detecting the presence of analytes (4) in a sample by binding of the analytes to the biomolecules. The biomolecules (3) are attached directly to the surface of the substrate together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent nonspecific binding of analytes (4) and other biomolecules. The invention relates also to a biosensor where biomolecules (3) are attached directly to the substrate (1) together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent non-specific binding of analytes (4) and other biomolecules. The biomolecules (5) can be self-assembled hydrophilic polymers. One example of using the invention is immunological analysis using surface plasmon resonance (SPR).Type: GrantFiled: April 16, 2007Date of Patent: March 31, 2009Assignee: Bionavis Ltd.Inventors: Inger Vikholm, Janusz Sadowski
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Patent number: 7332327Abstract: In a method for analysis biomolecules (3) attached to a solid surface of a substrate (1) are used for detecting the presence of analytes (4) in a sample by binding of the analytes to the biomolecules. The biomolecules (3) are attached directly to the surface of the substrate together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent nonspecific binding of analytes (4) and other biomolecules. The invention relates also to a biosensor where biomolecules (3) are attached directly to the substrate (1) together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent non-specific binding of analytes (4) and other biomolecules. The biomolecules (5) can be self-assembled hydrophilic polymers. One example of using the invention is immunological analysis using surface plasmon resonance (SPR).Type: GrantFiled: June 10, 2002Date of Patent: February 19, 2008Assignee: BioNavis Ltd.Inventors: Inger Vikholm, Janusz Sadowski
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Publication number: 20080024783Abstract: A method and a device for carrying out surface plasmon resonance measurement. A beam of electromagnetic radiation is produced by a source of electromagnetic radiation. The beam of electromagnetic radiation is directed through a prism onto a material layer in an angle of incidence, which material layer covers a planar surface of the prism. A resonance phenomenon is caused. A beam of reflected electromagnetic radiation is produced and directed by the surface to a detector for detecting the level of intensity of the beam of reflected electromagnetic radiation. The change of intensity of the beam of reflected electromagnetic radiation, caused by the surface resonance phenomenon, is measured. The beam of reflected electromagnetic radiation is reflected with a mirror to the detector.Type: ApplicationFiled: November 19, 2003Publication date: January 31, 2008Applicant: Beanor OYInventor: Janusz Sadowski
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Publication number: 20070254382Abstract: In a method for analysis biomolecules (3) attached to a solid surface of a substrate (1) are used for detecting the presence of analytes (4) in a sample by binding of the analytes to the biomolecules. The biomolecules (3) are attached directly to the surface of the substrate together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent nonspecific binding of analytes (4) and other biomolecules. The invention relates also to a biosensor where biomolecules (3) are attached directly to the substrate (1) together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent non-specific binding of analytes (4) and other biomolecules. The biomolecules (5) can be self-assembled hydrophilic polymers. One example of using the invention is immunological analysis using surface plasmon resonance (SPR).Type: ApplicationFiled: April 16, 2007Publication date: November 1, 2007Applicant: BEANOR OYInventors: Inger Vikholm, Janusz Sadowski
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Publication number: 20070157873Abstract: A method of fabricating devices comprising elongated nanosize elements as well as such devices are disclosed. The devices comprise epitaxially grown layers into which elongated nanosize elements, such as carbon nanotubes, are incorporated. A substrate supporting epitaxial growth of an epitaxial layer is provided, elongated nanosize elements is provided onto the substrate and epitaxially overgrown with an epitaxial layer. The elongate nanosize elements are thereby at least partly encapsulated by the epitaxially grown layer. One or more components are prepared in the layer, the one or more components being prepared by means of lithography. Devices with carbon nanotubes as the active element may thereby be provided. The method is suitable for hybrid devices, hybrid between conventional semiconductor devices and nano-devices.Type: ApplicationFiled: September 10, 2004Publication date: July 12, 2007Inventors: Jonas Hauptmann, Ane Jensen, Poul Erik Lindelof, Jesper Nygaard, Janusz Sadowski
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Patent number: 7009186Abstract: In a method for monitoring of polymer in a liquid state, such as a polymer melt or resin, to detect inhomogeneities therein, such as the presence of other phase objects, especially gels in a matrix formed of the liquid state, the polymer in a liquid state flowing past an inspection point is monitored. At the inspection point, electromagnetic radiation in the form of UV light or polarised electromagnetic radiation is passed through the flow chamber (1) and received by a detector (8), and the absorption of the UV light or the changes in the state of polarisation of the electromagnetic radiation caused by the inhomogeneities are used to observe them.Type: GrantFiled: January 3, 2002Date of Patent: March 7, 2006Assignee: Valtion Teknillinen TutkimuskeskusInventors: Janusz Sadowski, Jyrki Salminen, Peter Huber, Camie Heffels, Marian Mours, Klaus Reindel, Jürgen Ettmüller
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Publication number: 20040070752Abstract: In a method for monitoring of polymer in a liquid state, such as a polymer melt or resin, to detect inhomogeneities therein, such as the presence of other phase objects, especially gels in a matrix formed of the liquid state, the polymer in a liquid state flowing past an inspection point is monitored. At the inspection point, electromagnetic radiation in the form of UV light or polarised electromagnetic radiation is passed through the flow chamber (1) and received by a detector (8), and the absorption of the UV light or the changes in the state of polarisation of the electromagnetic radiation caused by the inhomogeneities are used to observe them.Type: ApplicationFiled: November 24, 2003Publication date: April 15, 2004Inventors: Janusz Sadowski, Jyrki Salminen, Peter Huber, Camie Heffels, Marian Mours, Klaus Reindel, Jurgen Ettmuller
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Publication number: 20030059954Abstract: In a method for analysis biomolecules (3) attached to a solid surface of a substrate (1) are used for detecting the presence of analytes (4) in a sample by binding of the analytes to the biomolecules. The biomolecules (3) are attached directly to the surface of the substrate together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent nonspecific binding of analytes (4) and other biomolecules. The invention relates also to a biosensor where biomolecules (3) are attached directly to the substrate (1) together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent non-specific binding of analytes (4) and other biomolecules. The biomolecules (5) can be self-assembled hydrophilic polymers. One example of using the invention is immunological analysis using surface plasmon resonance (SPR).Type: ApplicationFiled: June 10, 2002Publication date: March 27, 2003Inventors: Inger Vikholm, Janusz Sadowski