Patents by Inventor Janusz Sadowski

Janusz Sadowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10495571
    Abstract: A method for monitoring surface phenomena includes measuring a first surface plasmon resonance angle value (?SPR,REF) of a sample region (REG1), measuring a first critical angle value (?TIR,REF) of the sample region (REG1), causing a change of surface concentration (cM1,SRF) of an analyte (M1) at the sample region (REG1), changing the bulk composition at the sample region (REG1), measuring a second surface plasmon resonance angle value (?SPR(t)) of the sample region (REG1), measuring a second critical angle value (?TIR(t)) of the sample region (REG1), and determining an indicator value (?AUX(t)) indicative of the change of the surface concentration (cM1,SRF), wherein the indicator value (?AUX(t)) is determined from the second surface plasmon resonance angle value (?SPR(t)) by compensating an effect of the bulk composition, and wherein the magnitude (?COMP) of said effect is determined by using the second critical angle value (?TIR(t)).
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: December 3, 2019
    Assignee: BioNavis Oy
    Inventors: Janusz Sadowski, Niko Granqvist, Jussi Tuppurainen, Annika Jokinen
  • Publication number: 20170067826
    Abstract: A method for monitoring surface phenomena includes measuring a first surface plasmon resonance angle value (?SPR,REF) of a sample region (REG1), measuring a first critical angle value (?TIR,REF) of the sample region (REG1), causing a change of surface concentration (cM1,SRF) of an analyte (M1) at the sample region (REG1), changing the bulk composition at the sample region (REG1), measuring a second surface plasmon resonance angle value (?SPR(t)) of the sample region (REG1), measuring a second critical angle value (?TIR(t)) of the sample region (REG1), and determining an indicator value (?AUX(t)) indicative of the change of the surface concentration (cM1,SRF), wherein the indicator value (?AUX(t)) is determined from the second surface plasmon resonance angle value (?SPR(t)) by compensating an effect of the bulk composition, and wherein the magnitude (?COMP) of said effect is determined by using the second critical angle value (?TIR(t)).
    Type: Application
    Filed: February 18, 2015
    Publication date: March 9, 2017
    Inventors: Janusz SADOWSKI, Niko GRANQVIST, Jussi TUPPURAINEN, Annika JOKINEN
  • Patent number: 7701582
    Abstract: A method and a device for carrying out surface plasmon resonance measurement. A beam of electromagnetic radiation is produced by a source of electromagnetic radiation. The beam of electromagnetic radiation is directed through a prism onto a material layer in an angle of incidence, which material layer covers a planar surface of the prism. A resonance phenomenon is caused. A beam of reflected electromagnetic radiation is produced and directed by the surface to a detector for detecting the level of intensity of the beam of reflected electromagnetic radiation. The change of intensity of the beam of reflected electromagnetic radiation, caused by the surface resonance phenomenon, is measured. The beam of reflected electromagnetic radiation is reflected with a mirror to the detector.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: April 20, 2010
    Assignee: Beanor Oy
    Inventor: Janusz Sadowski
  • Patent number: 7510882
    Abstract: In a method for analysis biomolecules (3) attached to a solid surface of a substrate (1) are used for detecting the presence of analytes (4) in a sample by binding of the analytes to the biomolecules. The biomolecules (3) are attached directly to the surface of the substrate together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent nonspecific binding of analytes (4) and other biomolecules. The invention relates also to a biosensor where biomolecules (3) are attached directly to the substrate (1) together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent non-specific binding of analytes (4) and other biomolecules. The biomolecules (5) can be self-assembled hydrophilic polymers. One example of using the invention is immunological analysis using surface plasmon resonance (SPR).
    Type: Grant
    Filed: April 16, 2007
    Date of Patent: March 31, 2009
    Assignee: Bionavis Ltd.
    Inventors: Inger Vikholm, Janusz Sadowski
  • Patent number: 7332327
    Abstract: In a method for analysis biomolecules (3) attached to a solid surface of a substrate (1) are used for detecting the presence of analytes (4) in a sample by binding of the analytes to the biomolecules. The biomolecules (3) are attached directly to the surface of the substrate together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent nonspecific binding of analytes (4) and other biomolecules. The invention relates also to a biosensor where biomolecules (3) are attached directly to the substrate (1) together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent non-specific binding of analytes (4) and other biomolecules. The biomolecules (5) can be self-assembled hydrophilic polymers. One example of using the invention is immunological analysis using surface plasmon resonance (SPR).
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: February 19, 2008
    Assignee: BioNavis Ltd.
    Inventors: Inger Vikholm, Janusz Sadowski
  • Publication number: 20080024783
    Abstract: A method and a device for carrying out surface plasmon resonance measurement. A beam of electromagnetic radiation is produced by a source of electromagnetic radiation. The beam of electromagnetic radiation is directed through a prism onto a material layer in an angle of incidence, which material layer covers a planar surface of the prism. A resonance phenomenon is caused. A beam of reflected electromagnetic radiation is produced and directed by the surface to a detector for detecting the level of intensity of the beam of reflected electromagnetic radiation. The change of intensity of the beam of reflected electromagnetic radiation, caused by the surface resonance phenomenon, is measured. The beam of reflected electromagnetic radiation is reflected with a mirror to the detector.
    Type: Application
    Filed: November 19, 2003
    Publication date: January 31, 2008
    Applicant: Beanor OY
    Inventor: Janusz Sadowski
  • Publication number: 20070254382
    Abstract: In a method for analysis biomolecules (3) attached to a solid surface of a substrate (1) are used for detecting the presence of analytes (4) in a sample by binding of the analytes to the biomolecules. The biomolecules (3) are attached directly to the surface of the substrate together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent nonspecific binding of analytes (4) and other biomolecules. The invention relates also to a biosensor where biomolecules (3) are attached directly to the substrate (1) together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent non-specific binding of analytes (4) and other biomolecules. The biomolecules (5) can be self-assembled hydrophilic polymers. One example of using the invention is immunological analysis using surface plasmon resonance (SPR).
    Type: Application
    Filed: April 16, 2007
    Publication date: November 1, 2007
    Applicant: BEANOR OY
    Inventors: Inger Vikholm, Janusz Sadowski
  • Publication number: 20070157873
    Abstract: A method of fabricating devices comprising elongated nanosize elements as well as such devices are disclosed. The devices comprise epitaxially grown layers into which elongated nanosize elements, such as carbon nanotubes, are incorporated. A substrate supporting epitaxial growth of an epitaxial layer is provided, elongated nanosize elements is provided onto the substrate and epitaxially overgrown with an epitaxial layer. The elongate nanosize elements are thereby at least partly encapsulated by the epitaxially grown layer. One or more components are prepared in the layer, the one or more components being prepared by means of lithography. Devices with carbon nanotubes as the active element may thereby be provided. The method is suitable for hybrid devices, hybrid between conventional semiconductor devices and nano-devices.
    Type: Application
    Filed: September 10, 2004
    Publication date: July 12, 2007
    Inventors: Jonas Hauptmann, Ane Jensen, Poul Erik Lindelof, Jesper Nygaard, Janusz Sadowski
  • Patent number: 7009186
    Abstract: In a method for monitoring of polymer in a liquid state, such as a polymer melt or resin, to detect inhomogeneities therein, such as the presence of other phase objects, especially gels in a matrix formed of the liquid state, the polymer in a liquid state flowing past an inspection point is monitored. At the inspection point, electromagnetic radiation in the form of UV light or polarised electromagnetic radiation is passed through the flow chamber (1) and received by a detector (8), and the absorption of the UV light or the changes in the state of polarisation of the electromagnetic radiation caused by the inhomogeneities are used to observe them.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: March 7, 2006
    Assignee: Valtion Teknillinen Tutkimuskeskus
    Inventors: Janusz Sadowski, Jyrki Salminen, Peter Huber, Camie Heffels, Marian Mours, Klaus Reindel, Jürgen Ettmüller
  • Publication number: 20040070752
    Abstract: In a method for monitoring of polymer in a liquid state, such as a polymer melt or resin, to detect inhomogeneities therein, such as the presence of other phase objects, especially gels in a matrix formed of the liquid state, the polymer in a liquid state flowing past an inspection point is monitored. At the inspection point, electromagnetic radiation in the form of UV light or polarised electromagnetic radiation is passed through the flow chamber (1) and received by a detector (8), and the absorption of the UV light or the changes in the state of polarisation of the electromagnetic radiation caused by the inhomogeneities are used to observe them.
    Type: Application
    Filed: November 24, 2003
    Publication date: April 15, 2004
    Inventors: Janusz Sadowski, Jyrki Salminen, Peter Huber, Camie Heffels, Marian Mours, Klaus Reindel, Jurgen Ettmuller
  • Publication number: 20030059954
    Abstract: In a method for analysis biomolecules (3) attached to a solid surface of a substrate (1) are used for detecting the presence of analytes (4) in a sample by binding of the analytes to the biomolecules. The biomolecules (3) are attached directly to the surface of the substrate together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent nonspecific binding of analytes (4) and other biomolecules. The invention relates also to a biosensor where biomolecules (3) are attached directly to the substrate (1) together with biomolecule-repellent molecules (5), which cover the surface between the biomolecules (3) to prevent non-specific binding of analytes (4) and other biomolecules. The biomolecules (5) can be self-assembled hydrophilic polymers. One example of using the invention is immunological analysis using surface plasmon resonance (SPR).
    Type: Application
    Filed: June 10, 2002
    Publication date: March 27, 2003
    Inventors: Inger Vikholm, Janusz Sadowski