Abstract: The invention provides a combination comprising (a) S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]2-methylpropanethioate or prodrug of the active form thereof, and (b) at least one HMG CoA reductase inhibitor. Also provided are a pharmaceutical composition, package, and a kit comprising the aforementioned active ingredients, as well as a method for treatment and prophylaxis of a cardiovascular disorder involving the use of the aforementioned active ingredients.

Abstract: The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, the present invention provides, for example, compounds represented by the formulas (6), (7-1), (7-2) and (8): wherein R is a fluorine atom or a methoxy group, R1 is a C1-C4 alkyl group, R2 is a hydroxyl-protecting group, and X2 is a halogen atom, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.

Abstract: Provided is a method of treating or preventing diabetes in a subject comprising administering a therapeutically effective amount of (a) a compound of formula (I) or a pharmaceutically acceptable salt thereof, and (b) a DPP-IV inhibitor, to a subject that has or is at risk of having diabetes, whereupon diabetes is treated or prevented in the subject. The method optionally comprises administering a therapeutically effective amount of the compound of formula (I), or a pharmaceutically acceptable salt thereof, to the subject, in which the therapeutically effective amount is increased once or twice during the course of administration.

Abstract: The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2?): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.

Abstract: The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.

Abstract: A method of producing flavor-releasing granules, includes adding ethanol, together with a plurality of flavorant compounds, to an aqueous solution containing a plurality of cyclodextrin compounds and conducting stirring to include the flavorant compounds within the cyclodextrin compounds, intermittently spraying the obtained aqueous solution onto hygroscopic core particles in a state of planetary motion to adhere the flavorant inclusion cyclodextrin compounds to the respective surfaces of the core particles.

Abstract: To analyze an inspection image obtained by taking an image of filter end faces of filter cigarettes horizontally arranged, from an axial direction, and thus inspect an excess cigarette feeding error, there are provided a first judging device that the number of cigarettes according to shape information of the filter end faces obtained from the inspection image, and a second judging device that obtains the centroid positions of the filter end faces from the inspection image, and detects that there is an excess feeding error when difference between a maximum value and a minimum value of the centroid-to-centroid distance of adjacent filter end faces is substantially equal to a previously-known diameter of the filter end face.

Abstract: Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

Abstract: A cigarette comprising a tobacco rod comprising a tobacco filler and a cigarette paper which is wrapped around the tobacco filler, a filter comprising a filter member and a filter wrapping paper which is integrally wrapped around the filter member, and a tipping member which is bonded onto the tobacco rod and the filter with a pressure-sensitive adhesive to connect the tobacco rod and the filter.

Abstract: A non-heating type flavor inhalator of the invention includes a hollow cylindrical holder (2) having an ambient air admission opening (16) at a front end thereof and a mouthpiece end (4) at a rear end thereof, and a flavor cartridge (30) extending inside the holder (2) from the ambient air admission opening (16) toward the mouthpiece end (4) along the axis of the holder (2). The flavor cartridge (30) accommodates a flavor generating material (32) containing granular tobacco, and the flavor generating material (32) is kept in a predetermined required compressed state.

Abstract: A tobacco-flavor-releasing material includes granules which contain (a) a ground tobacco material, (b) water, (c) a moisturizing agent includes a polyhydric alcohol, (d) at least one pH-adjusting agent selected from the group consisting of potassium carbonate and sodium hydrogencarbonate, and (e) at least one binder selected from the group consisting of pullulan and hydroxypropyl cellulose.

Abstract: A smokeless flavor inhalator includes a tobacco material as a flavor generator, and a heater for heating the tobacco material to allow flavor components to be released from the tobacco material while preventing smoke from being generated from the tobacco material. The heater has a carbon heat source and a cooling element. The carbon heat source and the cooling element cooperatively keep the heating temperature of the tobacco material at a temperature of 50 to 200° C.

Abstract: A tobacco product produced by wrapping cut tobacco with a pouch or a cigarette paper, wherein the pouch or the cigarette paper has an inner layer and an outer layer, and a paper of the outer layer has an air permeability higher than that of a paper of the inner layer.

Abstract: Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

Abstract: The present invention aims to provide a novel Agrobacterium-mediated method for producing a transformed plant. The method of the present invention is an Agrobacterium-mediated method for producing a transformed plant, which comprises: (i) a coculture step for culturing an Agrobacterium-inoculated plant material with a coculture medium; and (ii) a regeneration step for culturing the tissue obtained in (i) with a regeneration medium, either without callus growth culture or after callus growth culture, to thereby regenerate a whole plant, wherein 1) said method comprises transformation enhancement, and wherein 2) said method does not comprise selection of transformed cells based on the properties of a nucleic acid to be introduced by Agrobacterium in any step from coculture to regeneration.

Abstract: Provided is an agent for the treatment or prophylaxis of inflammatory diseases, allergic diseases, autoimmune diseases, transplant rejection or the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as described in the specification.

Abstract: An image of the filter end faces of a bundle of cigarettes arranged side by side with axes thereof paralleled is acquired as an inspection image, and the diameters of the individual cigarettes of the bundle in the inspection image are obtained and compared with normal diameters associated with the respective cigarettes in the inspection image, to determine axial displacement of cigarettes from the bundle (first determination section). Also, the centers of gravity of the end faces of the individual cigarettes are obtained, and based on the difference between an inter-center-of-gravity distance which is the distance between an outermost cigarette in the bundle and its adjacent cigarette, and an inter-center-of-gravity distance which is the distance between adjacent cigarettes located in the central part of the bundle and belonging to the same tier as the outermost cigarette, axial displacement of the outermost cigarettes is determined (second determination section).

Abstract: The present invention provides novel cosmid vectors for plant transformation. The cosmid vectors have a full length of 15 kb or less and contain: 1) an origin of replication of an IncP plasmid, but not any origin of replication of other plasmid groups; 2) the trfA1 gene of an IncP plasmid; 3) an oriT of an IncP plasmid; 4) the incC1 gene of an IncP plasmid; 5) a cos site of lambda phage, which is located outside the T-DNA; 6) a drug resistance gene expressed in E. coli and a bacterium of Agrobacterium; 7) a T-DNA right border sequence of a bacterium of Agrobacterium; 8) a T-DNA left border sequence of a bacterium of Agrobacterium; 9) a selectable marker gene for plant transformation located between 7) and 8) and expressed in a plant; and 10) restriction endonuclease recognition site(s) located between 7) and 8) for cloning a foreign gene.

Abstract: A cigarette filter includes filter plugs separated from each other and arranged through a cavity, a flavor capsule encapsulating a content liquid including a flavor in a shell and provided in the cavity between the filter plugs, and a liquid-impermeable tipping paper and/or filter wrapper wrapped around the filter plugs and the flavor capsule, wherein the content liquid comprises the flavor and a thickener and has a viscosity of 30 mPa·s or more.

Abstract: A cigarette includes a tobacco rod in which a tobacco filler containing cut tobacco is wrapped with a cigarette paper, the tobacco rod being constituted by a distal end portion, a proximal end portion and a center portion, and a filter, the proximal end portion being connected to the filter. The distal end portion includes a volatile flavor-containing material incorporated in a gel of a polysaccharide, the center portion includes or does not include the volatile flavor-containing material, the proximal end portion includes or does not include the volatile flavor-containing material, and there is no case where both the center portion and the proximal end portion include the volatile flavor-containing material.