Abstract: A suitcase with a protective cover includes a main body having two semi-sphere cases, two adaptors respectively mounted fixedly around the corresponding sides of the two semi-sphere cases, a close space formed by the two semi-sphere cases, the adaptors having at least one first adapting portion mounted along the locations around which each of the adaptors is mounted, two cover bodies, each of the cover bodies has an opening, a concave portion recessed from the opening, a positioning rim mounted around the side of the opening, the concave portion having depth being capable of having the cover bodies cover the semi-sphere cases, at least one second adapting portion mounted along the locations around which each of the positioning rims is mounted, and each cover body fixed on each corresponding semi-spheres case via the connection of the at least one first adapting portion and the second adapting portion.