Abstract: Disclosed herein are devices, systems, and methods for adjustably tensioning sutures, such as sutures used to close a catheter access site of a human patient. In some embodiments, a suture tensioning device includes a housing and an actuation member slidably coupled to the housing. The housing can include a first through-hole and a second through-hole at least partially aligned along an axis. The actuation member can include a third-through-hole. The suture tensioning device can further include a biasing member operably coupled between the actuation member and the housing. The biasing member can bias the actuation member to a first position in which the third through-hole is offset from the axis. The actuation member is movable to a second position in which the third through-hole is at least partially aligned with the first and second through-holes along the axis.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.