Abstract: A device for manipulating a user's hand a wrist portion and forearm portion, each having proximal and distal ends. A pivoting connection is operatively coupled with the proximal end of the wrist portion and distal end of the forearm portions such that the wrist portion is pivotally coupled to the forearm portion. The device has a first actuator operatively coupled to the wrist portion and a second actuator operatively coupled to the pivoting connection. The first actuator is configured to apply a rotational force to a hand support coupled to the wrist portion, thereby producing either supination or pronation of a user's wrist. The second actuator is configured to apply a rotational force to the pivoting connection, thereby producing either flexion, extension, abduction, or adduction of a user's wrist, depending upon whether the user's hand is palm-side down or in a thumb's up position.