Patents by Inventor Jared ELY
Jared ELY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11883557Abstract: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.Type: GrantFiled: May 9, 2022Date of Patent: January 30, 2024Assignee: THE SECANT GROUP, LLCInventors: Stephanie Reed, Carissa Smoot, Dennis Shull, Todd Crumbling, John D'Ottavio, Peter D. Gabriele, Jeremy J. Harris, Charles Brendan Nicholson, Jared Ely
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Publication number: 20220257828Abstract: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.Type: ApplicationFiled: May 9, 2022Publication date: August 18, 2022Inventors: Stephanie Reed, Carissa Smoot, Dennis Shull, Todd Crumbling, John D'Ottavio, Peter D. Gabriele, Jeremy J. Harris, Charles Brendan Nicholson, Jared Ely
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Patent number: 11406732Abstract: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.Type: GrantFiled: January 13, 2021Date of Patent: August 9, 2022Assignee: THE SECANT GROUP, LLCInventors: Stephanie Reed, Carissa Smoot, Dennis Shull, Todd Crumbling, John D'Ottavio, Peter D. Gabriele, Jeremy J. Harris, Charles Brendan Nicholson, Jared Ely
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Publication number: 20210138073Abstract: A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.Type: ApplicationFiled: January 21, 2021Publication date: May 13, 2021Inventors: Jeremy J. HARRIS, Charles Brendan NICHOLSON, Peter D. GABRIELE, Jared ELY, Brian GINN
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Publication number: 20210138109Abstract: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.Type: ApplicationFiled: January 13, 2021Publication date: May 13, 2021Inventors: Stephanie REED, Carissa SMOOT, Dennis SHULL, Todd CRUMBLING, John D'OTTAVIO, Peter D. GABRIELE, Jeremy J. HARRIS, Charles Brendan NICHOLSON, Jared ELY
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Publication number: 20210060214Abstract: An article includes a fibrous mat of poly(glycerol sebacate) (PGS) resin and a resin of a hydrogel forming polymer, such as a polyvinyl alcohol (PVOH). Methods of making such articles include electrospinning a combination of PGS resin and PVOH resin to form nanofibers and depositing the nanofibers onto a surface to form the fibrous mat. The mat is suitable for a variety of medical uses, including as a barrier that can be deployed in surgical procedures.Type: ApplicationFiled: August 28, 2020Publication date: March 4, 2021Inventors: Jeremy J. HARRIS, Jared ELY, Mevlut TASCAN, Peter D. GABRIELE, Todd CRUMBLING
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Patent number: 10918764Abstract: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.Type: GrantFiled: August 21, 2019Date of Patent: February 16, 2021Assignee: THE SECANT GROUP, LLCInventors: Stephanie Reed, Carissa Smoot, Dennis Shull, Todd Crumbling, John D'Ottavio, Peter D. Gabriele, Jeremy J. Harris, Charles Brendan Nicholson, Jared Ely
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Patent number: 10918729Abstract: A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.Type: GrantFiled: January 31, 2019Date of Patent: February 16, 2021Assignee: THE SECANT GROUP, LLCInventors: Jeremy J. Harris, Charles Brendan Nicholson, Peter D. Gabriele, Jared Ely, Brian Ginn
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Publication number: 20200179513Abstract: A method of cancer hyperthermia therapy includes placing a device including an exogenously-excitable polymeric material at a cancer hyperthermia therapy site of a patient. The method also includes supplying an exogenous energy to the device such that the exogenous energy excites the exogenously-excitable polymeric material at the cancer hyperthermia therapy site to heat the cancer hyperthermia therapy site to a hyperthermia temperature. A method of preparing a polymeric material includes combining an alcohol monomer, a seed of the polymeric material, and an aqueous liquid in a vessel. The method also includes adding an acid monomer to the vessel and supplying an exogenous energy to the vessel. The polymeric material is exogenously excited by the exogenous energy to heat the polymeric material. The method further includes removing water from the vessel and producing the polymeric material, which is a polyester, in the vessel.Type: ApplicationFiled: February 3, 2020Publication date: June 11, 2020Inventors: Peter D. GABRIELE, Jared ELY, Jeremy J. HARRIS
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Publication number: 20200061240Abstract: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.Type: ApplicationFiled: August 21, 2019Publication date: February 27, 2020Inventors: Stephanie REED, Carissa SMOOT, Dennis SHULL, Todd CRUMBLING, John D'OTTAVIO, Peter D. GABRIELE, Jeremy J. HARRIS, Charles Brendan NICHOLSON, Jared ELY
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Patent number: 10568962Abstract: A method of cancer hyperthermia therapy includes placing a device including an exogenously-excitable polymeric material at a cancer hyperthermia therapy site of a patient. The method also includes supplying an exogenous energy to the device such that the exogenous energy excites the exogenously-excitable polymeric material at the cancer hyperthermia therapy site to heat the cancer hyperthermia therapy site to a hyperthermia temperature. A method of preparing a polymeric material includes combining an alcohol monomer, a seed of the polymeric material, and an aqueous liquid in a vessel. The method also includes adding an acid monomer to the vessel and supplying an exogenous energy to the vessel. The polymeric material is exogenously excited by the exogenous energy to heat the polymeric material. The method further includes removing water from the vessel and producing the polymeric material, which is a polyester, in the vessel.Type: GrantFiled: June 2, 2016Date of Patent: February 25, 2020Assignee: THE SECANT GROUP, LLCInventors: Peter D. Gabriele, Jared Ely, Jeremy J. Harris
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Publication number: 20190231890Abstract: A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.Type: ApplicationFiled: January 31, 2019Publication date: August 1, 2019Inventors: Jeremy J. HARRIS, Charles Brendan NICHOLSON, Peter D. GABRIELE, Jared ELY, Brian GINN
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Publication number: 20160354466Abstract: A method of cancer hyperthermia therapy includes placing a device including an exogenously-excitable polymeric material at a cancer hyperthermia therapy site of a patient. The method also includes supplying an exogenous energy to the device such that the exogenous energy excites the exogenously-excitable polymeric material at the cancer hyperthermia therapy site to heat the cancer hyperthermia therapy site to a hyperthermia temperature. A method of preparing a polymeric material includes combining an alcohol monomer, a seed of the polymeric material, and an aqueous liquid in a vessel. The method also includes adding an acid monomer to the vessel and supplying an exogenous energy to the vessel. The polymeric material is exogenously excited by the exogenous energy to heat the polymeric material. The method further includes removing water from the vessel and producing the polymeric material, which is a polyester, in the vessel.Type: ApplicationFiled: June 2, 2016Publication date: December 8, 2016Inventors: Peter D. GABRIELE, Jared ELY, Jeremy J. HARRIS