Patents by Inventor Jared Spidel

Jared Spidel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-TAU ANTIBODIES AND USES THEREOF
    Publication number: 20240034777
    Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
    Type: Application
    Filed: January 4, 2023
    Publication date: February 1, 2024
    Inventors: Malcolm Ian Roberts, James Martin Staddon, Hettihewage Alfred Rohan De Silva, Jared Spidel, Hirofumi Aoyagi, Shigeru Akasofu, Yutaka Hashizume, Kishan Agarwala
  • Lysine conjugated immunoglobulins
    Patent number: 11753669
    Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: September 12, 2023
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Jared Spidel, Earl Albone
  • ERIBULIN ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20230212310
    Abstract: Antibodies, antigen-binding fragments, and conjugates (e.g., antibody-drug conjugates such as those comprising eribulin) thereof that bind to mesothelin are disclosed. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the compositions provided herein.
    Type: Application
    Filed: December 23, 2022
    Publication date: July 6, 2023
    Inventors: Earl F. ALBONE, Jared SPIDEL
  • Anti-Tau antibodies and uses thereof
    Patent number: 11578120
    Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: February 14, 2023
    Assignees: Eisai R&D Management Co., Ltd., UCL Business LTD
    Inventors: Malcolm Ian Roberts, James Martin Staddon, Hettihewage Alfred Rohan De Silva, Jared Spidel, Hirofumi Aoyagi, Shigeru Akasofu, Yutaka Hashizume, Kishan Agarwala
  • Eribulin antibody-drug conjugates and methods of use
    Patent number: 11572414
    Abstract: Antibodies, antigen-binding fragments, and conjugates (e.g., antibody-drug conjugates such as those comprising eribulin) thereof that bind to mesothelin are disclosed. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the compositions provided herein.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: February 7, 2023
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Earl F. Albone, Jared Spidel
  • CYS80 CONJUGATED IMMUNOGLOBULINS
    Publication number: 20230001004
    Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.
    Type: Application
    Filed: September 2, 2021
    Publication date: January 5, 2023
    Inventors: Luigi Grasso, Jared Spidel, James Bradford Kline, Earl Albone
  • C-TERMINAL LYSINE CONJUGATED IMMUNOGLOBULINS
    Publication number: 20220088212
    Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
    Type: Application
    Filed: August 20, 2021
    Publication date: March 24, 2022
    Inventors: Jared Spidel, Earl Albone
  • C-terminal lysine conjugated immunoglobulins
    Patent number: 11135304
    Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: October 5, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Jared Spidel, Earl Albone
  • Cys80 conjugated immunoglobulins
    Patent number: 11129904
    Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: September 28, 2021
    Assignee: Eisai R&D Managment Co., Ltd.
    Inventors: Luigi Grasso, Jared Spidel, James Bradford Kline, Earl Albone
  • ERIBULIN ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
    Publication number: 20210238304
    Abstract: Antibodies, antigen-binding fragments, and conjugates (e.g., antibody-drug conjugates such as those comprising eribulin) thereof that bind to mesothelin are disclosed. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the compositions provided herein.
    Type: Application
    Filed: November 6, 2020
    Publication date: August 5, 2021
    Inventors: Earl F. ALBONE, Jared SPIDEL
  • LYSINE CONJUGATED IMMUNOGLOBULINS
    Publication number: 20210171998
    Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
    Type: Application
    Filed: January 27, 2021
    Publication date: June 10, 2021
    Inventors: Jared Spidel, Earl Albone
  • Lysine conjugated immunoglobulins
    Patent number: 10941431
    Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: March 9, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Jared Spidel, Earl Albone
  • ANTI-TAU ANTIBODIES AND USES THEREOF
    Publication number: 20210024622
    Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
    Type: Application
    Filed: September 24, 2020
    Publication date: January 28, 2021
    Inventors: Malcolm Ian Roberts, James Martin Staddon, Hettihewage Alfred Rohan De Silva, Jared Spidel, Hirofumi Aoyagi, Shigeru Akasofu, Yutaka Hashizume, Kishan Agarwala
  • Anti-tau antibodies and uses thereof
    Patent number: 10829547
    Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: November 10, 2020
    Assignees: Eisai R&D Management Co., Ltd., UCL Business LTD
    Inventors: Malcolm Ian Roberts, James Martin Staddon, Hettihewage Alfred Rohan De Silva, Jared Spidel, Hirofumi Aoyagi, Shigeru Akasofu, Yutaka Hashizume, Kishan Agarwala
  • C-TERMINAL LYSINE CONJUGATED IMMUNOGLOBULINS
    Publication number: 20200009263
    Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.
    Type: Application
    Filed: December 16, 2016
    Publication date: January 9, 2020
    Inventors: Jared Spidel, Earl Albone
  • Anti-Tau antibodies and uses thereof
    Patent number: 10358485
    Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: July 23, 2019
    Assignees: Eisai R&D Management Co., Ltd., UCL Business PLC
    Inventors: Malcolm Ian Roberts, James Martin Staddon, Hettihewage Alfred Rohan De Silva, Jared Spidel, Hirofumi Aoyagi, Shigeru Akasofu, Yutaka Hashizume, Kishan Agarwala
  • CYS80 CONJUGATED IMMUNOGLOBULINS
    Publication number: 20190202933
    Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 4, 2019
    Inventors: Luigi Grasso, Jared Spidel, James Bradford Kline, Earl Albone
  • CYS80 conjugated immunoglobulins
    Patent number: 10273310
    Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: April 30, 2019
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Luigi Grasso, Jared Spidel, James Bradford Kline, Earl Albone
  • ANTI-TAU ANTIBODIES AND USES THEREOF
    Publication number: 20190112365
    Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Inventors: Malcolm Ian Roberts, James Martin Staddon, Hettihewage Alfred Rohan De Silva, Jared Spidel, Hirofumi Aoyagi, Shigeru Akasofu, Yutaka Hashizume, Kishan Agarwala
  • ANTI-TAU ANTIBODIES AND USES THEREOF
    Publication number: 20190112364
    Abstract: Provided herein are antibodies that specifically bind Tau and methods of using the same.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Inventors: Malcolm Ian Roberts, James Martin Staddon, Hettihewage Alfred Rohan De Silva, Jared Spidel, Hirofumi Aoyagi, Shigeru Akasofu, Yutaka Hashizume, Kishan Agarwala