Abstract: Folded sheet product cartridges and dispensing assemblies, systems, and methods of dispense therefor are provided. A dispensing assembly includes a housing for vertically stacked cartridges. The housing defines a load opening in a side panel or top end and a dispensing slot in a side panel or bottom end. A sheet product cartridge includes a plurality of folded sheet products for dispense through a dispensing opening and a plurality of flexible material panels containing the sheet products. One of the material panels includes a detachable area that is detachable to form the dispensing opening.