Abstract: Disclosed is a technique for estimating a biomechanical structure of one or more derived human cardiomyocytes (CMs) on basis of at least one image that represents derived human CMs, the method including detecting respective image positions of predefined elements of the derived human CMs, including detecting first positions that indicate respective adhesion points of a cell outline of the derived human CMs where they attach to their substrate and detecting second positions that indicate respective positions of nuclei of the derived human CMs; dividing the image representation of the derived human CMs into a plurality of areas that represent respective sarcomeres of the derived human CMs; and carrying out a further analysis of the derived human CMs on basis of division of their image representation into the plurality of areas.

Abstract: A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement. The wound dressing according to the present invention provide a continuous, non-invasive and objective solution for monitoring chronic wound healing without disturbing the delicate healing process.

Abstract: A method for measuring vibration transmittance of a sternum noninvasively includes producing vibration, transmitting the vibration to a first side the sternum through skin and soft tissues, obtaining response data of the sternum from a second side of the sternum through skin and soft tissues, which first and second sides of the sternum are on different sides of the midline of the sternum, and processing said response data for determining transmittance of vibration of the sternum. The response data may be used for defining state of a patient such as sternal instability of the breastbone or abnormal healing in the sternum after open chest surgery by surgeons.

Abstract: Various embodiments relate to a method, apparatus, system, and a computer program product for suppressing an oscillatory signal Sosc. In the method a composite signal S comprising said Sosc and a modulating signal Smod are provided and the S is high pass filtered to produce estimates of the Sosc and the Smod, wherein the estimate of the Sosc comprises first oscillations during a first state of the modulating signal and second oscillations during a second state of the modulating signal. A first bin associated with said first state and a second bin associated with said second state are defined and assigned for said first oscillation and the second bin for said second oscillation according to a state defined from the estimate of the Smod. A first average waveform for said first oscillations and a second average waveform for said second oscillations are formed and used to suppress the Sosc signal from the composite signal S.

Abstract: Method for analyzing the beating of a derived human cardiomyocyte (CM) includes obtaining the derived human CM, capturing a sequence of images depicting the derived human CM over an analysis period, and determining at least one signal descriptive of the beating of the derived human CM during the analysis period on basis of the sequence of captured images. Apparatuses, and a computer program for analyzing the beating of a derived human CM are configured to obtain: the sequence of images depicting the derived human CM over an analysis period, information indicative of the region of the images depicting the derived human CM, information indicative of two or more sub-regions within the region, and determine two or more signals characterizing the displacement within the region of images depicting the derived human cardiomyocyte, each signal characterizing the extent of displacement within a respective sub-region of the region as a function of time.

Abstract: The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according to the present invention comprises at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement.

Abstract: Method for analyzing the beating of a derived human cardiomyocyte (CM) includes obtaining the derived human CM, capturing a sequence of images depicting the derived human CM over an analysis period, and determining at least one signal descriptive of the beating of the derived human CM during the analysis period on basis of the sequence of captured images. Apparatuses, and a computer program for analyzing the beating of a derived human CM are configured to obtain: the sequence of images depicting the derived human CM over an analysis period, information indicative of the region of the images depicting the derived human CM, information indicative of two or more sub-regions within the region, and determine two or more signals characterizing the displacement within the region of images depicting the derived human cardiomyocyte, each signal characterizing the extent of displacement within a respective sub-region of the region as a function of time.

Abstract: Arrangement for defining a location within an organism, said arrangement comprising: a hollow needle (2), comprising a longitudinal channel (5) and a distal end (4); a mandrin (1), accommodated in the longitudinal channel (5) in mobile manner in relation to it and removable from said channel (5) and having a distal and (3) of closed design, comprising an electrode pattern including at least two electrodes (7a, 7b, 7c, 7d); as well as a processing unit, configured to monitor the advancement of the distal end (4) only on the basis of a measurement signal of bio impedance received from the electrodes (7a, 7b, 7c, 7d) of the electrode pattern. The application includes also an independent claim for a method for manufacturing a mandrin to be accommodated in a needle.

Abstract: A method for measuring vibration transmittance of a sternum noninvasively includes producing vibration, transmitting the vibration to a first side the sternum through skin and soft tissues, obtaining response data of the sternum from a second side of the sternum through skin and soft tissues, which first and second sides of the sternum are on different sides of the midline of the sternum, and processing said response data for determining transmittance of vibration of the sternum. The response data may be used for defining state of a patient such as sternal instability of the breastbone or abnormal healing in the sternum after open chest surgery by surgeons.

Abstract: Various embodiments relate to a method, apparatus, system, and a computer program product for suppressing an oscillatory signal Sosc. In the method a composite signal S comprising said Sosc and a modulating signal Smod are provided and the S is high pass filtered to produce estimates of the Sosc and the Smod, wherein the estimate of the Sosc comprises first oscillations during a first state of the modulating signal and second oscillations during a second state of the modulating signal. A first bin associated with said first state and a second bin associated with said second state are defined and assigned for said first oscillation and the second bin for said second oscillation according to a state defined from the estimate of the Smod. A first average waveform for said first oscillations and a second average waveform for said second oscillations are formed and used to suppress the Sosc signal from the composite signal S.

Abstract: An arrangement for determining the position of a needle in an organ system and a method utilizing the arrangement in cosmetic treatment or cosmetic surgery. The arrangement (1) comprises a needle (2) with a distal tip (3), a measurement circuit (4) measuring the bioimpedance of tissues, a detection means (10) connected to the measurement circuit measuring bioimpedance and arranged to detect the progress of the distal tip (3) of the needle at a real-time basis from the bioimpedance measured from tissues. The arrangement (1) comprises at least two electrodes (16, 18, 21, 22) arranged at the distal tip (3) of the needle and connected to the measurement circuit (4). All the electrodes (16, 18, 21, 22) measuring impedance and needed for monitoring the progress of the distal tip (3) of the needle are arranged to the distal tip (3) of the needle.