Abstract: Method and device for manufacturing a thermally insulated container (1) for storing and transporting material such as vaccine, biological material and the like requiring a substantial constant temperature during a substantial period of time, the container comprising an insulated first can-shaped vessel (2) filled with a solid-to-liquid phase transforming refrigerant material (5). In a first step of the method a multilayer insulation is baked under vacuum and arranged about said first vessel (2) by wrapping so that it encloses said first vessel on all sides, in a second step said first vessel is inserted under vacuum into an outer vessel, in a third step the bottom part (18) and the cover part (19) of the container are welded together under vacuum.