Patents by Inventor Jaromir Kulhanek

Jaromir Kulhanek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chlorinated derivative of hyaluronic acid, method of preparation thereof, a composition containing the derivative, and use thereof
    Patent number: 11427652
    Abstract: A chlorinated derivative of hyaluronic acid or of a modified hyaluronic acid (chloramide) is provided. The chloramide has an amidic group (—NH—CO—). The hydrogen of the amidic group is substituted by a chlorine atom, according to the structural formula —NCl—CO—. The substitution degree of the hyaluronic acid or of the modified hyaluronic acid by chlorine is in an amount of from 50 to 100 %.
    Type: Grant
    Filed: August 17, 2019
    Date of Patent: August 30, 2022
    Assignee: CONTIPRO A.S.
    Inventors: Radovan Buffa, Ivana Basarabova, Martina Hermannova, Katerina Knotkova, Jaromir Kulhanek, Josef Chmelar, Tomá{hacek over (s)} Pitucha, Drahomira Chladkova, Helena Krejci, Hana Vagnerova, Martin Sojka, Lubos Sobotka, Vladimir Velebny
  • Composition comprising an iodide and a derivative of hyaluronic acid with an oxidative effect, method of preparation thereof and use thereof
    Patent number: 11425907
    Abstract: An antimicrobial composition is provided. The composition comprises a chloramid of hyaluronic acid or of modified hyaluronic acid. The chloramid has an amidic group (—NH—CO—). The hydrogens of the amidic group are substituted by chlorine atoms according to the structural formula —NCl—CO—. The composition further comprises an iodide. The substitution degree of the hyaluronic acid or of the modified hyaluronic acid by chlorine is in an amount of from 50% to 100%.
    Type: Grant
    Filed: August 17, 2019
    Date of Patent: August 30, 2022
    Assignee: CONTIPRO A.S.
    Inventors: Radovan Buffa, Vit Svozil, Katerina Knotkova, Veronika Stepankova, Jaromir Kulhanek, Josef Chmelar, Lucie Marholdova, Ivana Basarabova, Michaela Moravkova, Helena Krejci, Kristyna Lipenska, Jaroslav Novotny, Stanislav Pepeliaev, Lubos Sobotka, Vladimir Velebny
  • COMPOSITION COMPRISING AN IODIDE AND A DERIVATIVE OF HYALURONIC ACID WITH AN OXIDATIVE EFFECT, METHOD OF PREPARATION THEREOF AND USE THEREOF
    Publication number: 20210345610
    Abstract: An antimicrobial composition is provided. The composition comprises a chloramid of hyaluronic acid or of modified hyaluronic acid. The chloramid has an amidic group (—NH—CO—). The hydrogens of the amidic group are substituted by chlorine atoms according to the structural formula —NCl—CO—. The composition further comprises an iodide. The substitution degree of the hyaluronic acid or of the modified hyaluronic acid by chlorine is in an amount of from 50% to 100%.
    Type: Application
    Filed: August 17, 2019
    Publication date: November 11, 2021
    Inventors: Radovan BUFFA, Vit SVOZIL, Katerina KNOTKOVA, Veronika STEPANKOVA, Jaromir KULHANEK, Josef CHMELAR, Lucie MARHOLDOVA, Ivana BASARABOVA, Michaela MORAVKOVA, Helena KREJCI, Kristyna LIPENSKA, Jaroslav NOVOTNY, Stanislav PEPELIAEV, Lubos SOBOTKA, Vladimir VELEBNY
  • CHLORINATED DERIVATIVE OF HYALURONIC ACID, METHOD OF PREPARATION THEREOF, A COMPOSITION CONTAINING THE DERIVATIVE, AND USE THEREOF
    Publication number: 20210332161
    Abstract: A chlorinated derivative of hyaluronic acid or of a modified hyaluronic acid (chloramide) is provided. The chloramide has an amidic group (—NH—CO—). The hydrogen of the amidic group is substituted by a chlorine atom, according to the structural formula —NCl—CO—. The substitution degree of the hyaluronic acid or of the modified hyaluronic acid by chlorine is in an amount of from 50 to 100 %.
    Type: Application
    Filed: August 17, 2019
    Publication date: October 28, 2021
    Inventors: Radovan BUFFA, Ivana BASARABOVA, Martina HERMANNOVA, Katerina KNOTKOVA, Jaromir KULHANEK, Josef CHMELAR, Tomás PITUCHA, Drahomira CHLADKOVA, Helena KREJCI, Hana VAGNEROVA, Martin SOJKA, Lubos SOBOTKA, Vladimir VELEBNY
  • C-C-acylated derivative of hyaluronic acid and method of preparation thereof
    Patent number: 9999678
    Abstract: The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: June 19, 2018
    Assignee: Contipro a.s.
    Inventors: Daniela Smejkalova, Gloria Huerta-Angeles, Martin Bobek, Martina Hermannova, Lucie Vistejnova, Jaroslav Novotny, Eva Prikopova, Kristina Nesporova, Miroslava Nemcova, Klara Slezingrova, Jaromir Kulhanek, Dagmar Cozikova, Jana Sogorkova, Jan Kucera, Pavel Klein, Vladimir Velebny
  • C6-C18-Acylated Derivative of Hyaluronic Acid, Method of Preparation Thereof, Nanomicellar Composition on its Basis, Method of Preparation Thereof and Method of Preparation Stabilized Nanomicellar Composition, and Use Thereof
    Publication number: 20150320873
    Abstract: The invention relates to a method of preparation hydrophobized hyaluronic acid (Formula I) and further to a method of encapsulating biologically active substances into the nanomicelles of hydrophobized hyaluronan serving as carriers of biologically active hydrophobic substances. The hydrophobization of hyaluronan is carried out through an esterification reaction of hyaluronan with long-chain carboxylic acids, the latter being activated by a halogenide derivative of 2,4,6-trichlorobenzoic acid or by another organic chloride. In an aqueous environment, water-soluble hydrophobized derivatives can form nanomicelles in which nonpolar substances can be bound by means of non-covalent physical interactions. The core of a nanomicelle is formed by hydrophobic acyl functional groups while the shell of a nanomicelle is formed by hyaluronic acid. The encapsulation of the substances into nanomicelles can be performed by means of the solvent exchange method or by means of sonication.
    Type: Application
    Filed: November 26, 2013
    Publication date: November 12, 2015
    Inventors: Daniela Smejkalova, Gloria Huerta-Angeles, Martin Bobek, Martina Hermannova, Lucie Vistejnova, Jaroslav Novotny, Eva Prikopova, Kristina Nesporova, Miroslava Nemcova, Klara Slezingrova, Jaromir Kulhanek, Dagmar Cozikova, Jana Sogorkova, Jan Kucera, Pavel Klein, Vladimir Velebny
  • Endless Fibres on the Basis of Hyaluronan Selectively Oxidized in the Position 6 of the N-Acetyl-D-Glucosamine Group, Preparation and Use Thereof, Threads, Staples, Yarns, Fabrics Made Thereof and Method for Modifying the Same
    Publication number: 20150299911
    Abstract: The present invention relates to the preparation of textile processable endless monofilaments and multifilaments on the basis of hyaluronan which has been selectively oxidized to aldehyde in the position 6 of its/V-acetyl-D-glucosamine group and to the subsequent modification of such filaments with low molecular dihydrazides. The fibres as well as the fabrics, which are subsequently prepared from the former, exhibit a time-varying solubility in saline depending on the external modification of the fibres. After having been externally modified, the fibres as well as the fabrics exhibit a prolong period of transition into an evenly distributed gel layer. The externally modified fibrous materials retain their full biocompatibility.
    Type: Application
    Filed: November 26, 2013
    Publication date: October 22, 2015
    Inventors: Jiri Betak, Radovan Buffa, Miroslava Nemcova, Tomas Pitucha, Jaromir Kulhanek, Ilona Matejkova, Jana Novakova, Lucie Vistejnova, Pavel Klein, Gabriela Kubickova, Marketa Broulikova, Michaela Felgrova, Vladimir Velebny