Abstract: In some embodiments, a balloon-expandable prosthetic heart valve includes a collapsible and expandable stent comprising a plurality of commissure attachment features, the collapsible and expandable stent having at least one of an inflow flare and an outflow flare, and a valve assembly coupled to the collapsible and expandable stent, the valve assembly comprising a cuff and a plurality of leaflets, the plurality of leaflets defining a noncylindrical profile with a narrowed waist.

Abstract: In some embodiments, a prosthetic heart valve includes a collapsible and expandable stent comprising a plurality of commissure attachment features, a valve assembly coupled to the collapsible and expandable stent, the valve assembly comprising a cuff and a plurality of leaflets, and a suture pattern coupling at least one of the plurality of leaflets to at least one of the cuff and the collapsible and expandable stent, the suture pattern comprising a reverse-running stitch having a first leg and a second leg.

Abstract: A prosthetic heart valve may include a balloon-expandable frame extending between an inflow end and an outflow end, a plurality of prosthetic leaflets mounted within the frame, and an inner skirt positioned between the plurality of prosthetic leaflets and the frame. The frame may include a first row of diamond-shaped cells at the inflow end of the frame, a second row of diamond-shaped cells, and a row of outflow cells positioned at the outflow end of the frame. Each cell in the row of outflow cells may not be diamond-shaped, and, in an expanded condition of the frame, each cell in the row of outflow cells may have a larger area than that of each cell in the first and second rows of diamond-shaped cells. Each outflow cell may be at least partially defined by a commissure attachment feature, and each outflow cell may lack symmetry.

Abstract: A prosthetic heart valve includes a collapsible and expandable stent having an inflow end and an outflow end, and a plurality of struts defining a plurality of cells, the stent being formed of a first material, a plurality of commissure attachment features formed of a second material that is different than the first material of the stent, and a collapsible and expandable valve assembly including a plurality of leaflets connected to the plurality of commissure attachment features.

Abstract: A delivery device is configured for aligning and stabilizing a prosthetic heart valve for deployment in a native heart valve annulus. The device includes a catheter assembly having an inner shaft around which a valve compartment is defined, an outer shaft assembled over the inner shaft and adapted to slide relative to the inner shaft, a distal sheath connected to a distal end of the outer shaft and slidable therewith, an outer tube assembled over the outer shaft, and an alignment and stabilization device having a collapsed condition and an expanded condition. The outer tube is adapted to slide relative to the outer shaft to selectively cover and uncover the alignment and stabilization device.

Abstract: A prosthetic heart valve may include a collapsible and expandable stent, a cuff attached to an annulus section of the stent, and a plurality of leaflets attached to at least one of the cuff or the stent within an interior region of the stent. The stent may have a plurality of cells connected to one another in a plurality of annular rows around the stent. The leaflets together may have a coapted position occluding the interior region of the stent and an open position in which the interior region is not occluded. Each leaflet may include a flat mesh of braided wire material having a plurality of pores extending therethrough. The leaflets may be devoid of biological material at a time of implantation.

Abstract: A prosthetic heart valve may include a collapsible and expandable stent, a cuff attached to an annulus section of the stent, and a plurality of leaflets attached to at least one of the cuff or the stent within an interior region of the stent. The stent may have a plurality of cells connected to one another in a plurality of annular rows around the stent. The leaflets together may have a coapted position occluding the interior region of the stent and an open position in which the interior region is not occluded. Each leaflet may include a flat mesh of braided wire material having a plurality of pores extending therethrough. The leaflets may be devoid of biological material at a time of implantation.

Abstract: A delivery device is configured for aligning and stabilizing a prosthetic heart valve for deployment in a native heart valve annulus. The device includes a catheter assembly having an inner shaft around which a valve compartment is defined, an outer shaft assembled over the inner shaft and adapted to slide relative to the inner shaft, a distal sheath connected to a distal end of the outer shaft and slidable therewith, an outer tube assembled over the outer shaft, and an alignment and stabilization device having a collapsed condition and an expanded condition. The outer tube is adapted to slide relative to the outer shaft to selectively cover and uncover the alignment and stabilization device.

Abstract: Combined embolic protection devices and prosthetic heart valve delivery devices useful for filtering emboli during a heart valve replacement procedure are described. The delivery devices may include a delivery sheath for housing the prosthetic heart valve in collapsed condition for delivery. The delivery devices may include one or more embolic protection filters received within the delivery device during the delivery of the prosthetic heart valve. The embolic protection filters may be deployed into an expanded or deployed condition prior to deploying the prosthetic heart valve. Any embolic debris entering the bloodstream during the prosthetic heart valve deployment may be trapped within, or deflected by, the deployed embolic filter(s) to reduce the risk of stroke.