Patents by Inventor Jaroslav Frantisek

Jaroslav Frantisek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates and processes for preparing Ticagrelor
    Patent number: 9056838
    Abstract: The present invention is related to new intermediates and processes for preparing Ticagrelor disclosed in this patent application.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: June 16, 2015
    Assignee: TEVA PHARMACEUTICAL INDUSTRIES LTD.
    Inventors: Vinod Kumar Kansal, Dhirenkumar Mistry, Sanjay Vasoya, Ghanshyam Pandey, Amit Taneja, Pramod Kadappa Shindey, Jiri Stohandl, Jaroslav Frantisek
  • Process for preparing pyrrole derivatives and intermediates
    Patent number: 7932403
    Abstract: The present invention relates to a process for preparing pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process formula (I).
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: April 26, 2011
    Assignee: ratiopharm GmbH
    Inventors: Pavel Bobal, Jaroslav Frantisek, Jiri Stohandl, Kane Denike, Armin Boerner, Vitali Tararov, Andrei Korostylev, Gerd Koenig, Nicolas Jeker
  • Stereoselective method for the production of (R)-Dimepranol
    Patent number: 7799952
    Abstract: The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: September 21, 2010
    Assignee: ratiopharm GmbH
    Inventors: Jiri Stohandl, Jaroslav Frantisek, Winfried Ness
  • PROCESS FOR THE PREPARATION OF VALSARTAN AND INTERMEDIATE PRODUCTS
    Publication number: 20100217008
    Abstract: The present invention relates to a new method for the production of valsartan, a valine derivative having the chemical N name is (S)—N-(1-carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2?-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]amine, and pharmacologically acceptable salts thereof. Furthermore the invention relates to new intermediate compounds which are suitable for the production of valsartan and new methods for the production of intermediate compounds which are suitable for the production of valsartan.
    Type: Application
    Filed: December 11, 2007
    Publication date: August 26, 2010
    Applicant: ratiopharm GmbH
    Inventors: Jiri Stohandl, Pavel Bobal, Jaroslav Frantisek
  • Stereoselective Method for the Production of (R)-Dimepranol
    Publication number: 20090149677
    Abstract: The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.
    Type: Application
    Filed: February 10, 2009
    Publication date: June 11, 2009
    Applicant: ratiopharm GmbH
    Inventors: Jiri Stohandl, Jaroslav Frantisek, Winfried Ness
  • Stereoselective method for the production of Clopidogrel
    Patent number: 7507827
    Abstract: The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: March 24, 2009
    Assignee: ratiopharm GmbH
    Inventors: Jiri Stohandl, Jaroslav Frantisek, Winfried Ness
  • Process for Preparing Pyrrole Derivatives and Intermediates
    Publication number: 20090012312
    Abstract: The present invention relates to a process for preparing pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process formula (I).
    Type: Application
    Filed: December 16, 2005
    Publication date: January 8, 2009
    Inventors: Pavel Bobal, Jaroslav Frantisek, Jiri Stohandl, Kane Denike, Armin Boerner, Vitali Tararov, Andrci Korostylev, Gerd Koenig, Nicolas Jeker
  • Stereoselective Method for the Production of Clopidogrel
    Publication number: 20070219166
    Abstract: The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.
    Type: Application
    Filed: December 3, 2004
    Publication date: September 20, 2007
    Inventors: Jiri Stohandl, Jaroslav Frantisek, Winfried Ness