Patents by Inventor Jaroslav Pis

Jaroslav Pis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for Making Zoledronic Acid
    Publication number: 20100130746
    Abstract: Processes for making zoledronic acid can be advantageously carried out in a solvent/diluent that comprises a mixture of (i) a polyalkylene glycol and (ii) a cyclic carbonate of the formula (3) wherein n is an integer from 2 to 4, and R1 and R2 each independently represent a hydrogen or a C1-C4 alkyl group.
    Type: Application
    Filed: November 27, 2009
    Publication date: May 27, 2010
    Inventors: Martin Kas, Michal Benes, Jaroslav Pis
  • Process for purification of anastrozole
    Patent number: 7655806
    Abstract: Anastrozole can be purified by crystallization from an aqueous-based solvent system. The aqueous-based solvent system can contain dilute acid, or an alcohol or both.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: February 2, 2010
    Assignee: Synthon BV
    Inventors: Jaroslav Pis, Rudolf Smrz
  • PROCESS FOR MAKING ANASTROZOLE
    Publication number: 20080076933
    Abstract: A process for making anastrozole using a 1-substituted triazole can reduce formation of the undesired iso-anastrozole. A typical process is represented by wherein compound (10) is a 1-substituted triazole and compound (1) is anastrozole.
    Type: Application
    Filed: September 21, 2007
    Publication date: March 27, 2008
    Inventors: Michal Benes, Zdenek Prosek, Jiri Hykl, Jaroslav Pis
  • PROCESS FOR PURIFICATION OF ANASTROZOLE
    Publication number: 20070281982
    Abstract: Anastrozole can be purified by crystallization from an aqueous-based solvent system. The aqueous-based solvent system can contain dilute acid, or an alcohol or both.
    Type: Application
    Filed: May 18, 2007
    Publication date: December 6, 2007
    Inventors: Jaroslav Pis, Rudolf Smrz
  • Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
    Patent number: 6965051
    Abstract: Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: November 15, 2005
    Assignee: Synthon IP Inc.
    Inventors: Hans J. Hoorn, Theodorus H. A. Peters, Jaroslav Pis, Radim Scigel
  • Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
    Publication number: 20050096394
    Abstract: Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)— or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.
    Type: Application
    Filed: November 15, 2004
    Publication date: May 5, 2005
    Inventors: Hans Hoorn, Theodorus Peters, Jaroslav Pis, Radim Scigel
  • Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
    Patent number: 6835853
    Abstract: Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: December 28, 2004
    Assignee: Synthon BV
    Inventors: Hans J Hoorn, Theodorus H. A. Peters, Jaroslav Pis, Radim Scigel
  • Process for resolution of tamsulosin and compounds, compositons, and processes associated therewith
    Publication number: 20030109752
    Abstract: Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.
    Type: Application
    Filed: July 31, 2002
    Publication date: June 12, 2003
    Inventors: Hans J. Hoorn, Theodorus H.A. Peters, Jaroslav Pis, Radim Scigel